Human Gene LMNTD1 (ENST00000458174.7_10) from GENCODE V47lift37
  Description: lamin tail domain containing 1, transcript variant 1 (from RefSeq NM_001145728.2)
Gencode Transcript: ENST00000458174.7_10
Gencode Gene: ENSG00000152936.11_22
Transcript (Including UTRs)
   Position: hg19 chr12:25,629,016-25,706,217 Size: 77,202 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr12:25,656,694-25,705,893 Size: 49,200 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:25,629,016-25,706,217)mRNA (may differ from genome)Protein (409 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
MalacardsMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ILFT1_HUMAN
DESCRIPTION: RecName: Full=Intermediate filament tail domain-containing protein 1;
SIMILARITY: Belongs to the intermediate filament family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: LMNTD1
Diseases sorted by gene-association score: respiratory system benign neoplasm (2)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.10 RPKM in Testis
Total median expression: 4.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -62.50245-0.255 Picture PostScript Text
3' UTR -79.10401-0.197 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001664 - IF
IPR001322 - Lamin_tail_dom

Pfam Domains:
PF00932 - Lamin Tail Domain

SCOP Domains:
74853 - Lamin A/C globular tail domain

ModBase Predicted Comparative 3D Structure on Q8N9Z9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity

Biological Process:
GO:0008283 cell proliferation

Cellular Component:
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005882 intermediate filament


-  Descriptions from all associated GenBank mRNAs
  AK093323 - Homo sapiens cDNA FLJ36004 fis, clone TESTI2015331, weakly similar to LAMIN B3.
AX748055 - Sequence 1580 from Patent EP1308459.
BC037957 - Homo sapiens intermediate filament tail domain containing 1, mRNA (cDNA clone MGC:46346 IMAGE:5744078), complete cds.
AK302292 - Homo sapiens cDNA FLJ59636 complete cds.
AK296816 - Homo sapiens cDNA FLJ55850 complete cds.
AK310411 - Homo sapiens cDNA, FLJ17453.
KJ903923 - Synthetic construct Homo sapiens clone ccsbBroadEn_13317 IFLTD1 gene, encodes complete protein.
CU691522 - Synthetic construct Homo sapiens gateway clone IMAGE:100016666 5' read IFLTD1 mRNA.
JD359596 - Sequence 340620 from Patent EP1572962.
JD381434 - Sequence 362458 from Patent EP1572962.
JD304753 - Sequence 285777 from Patent EP1572962.
JD465642 - Sequence 446666 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DL27, B4DY70, ENST00000458174.1, ENST00000458174.2, ENST00000458174.3, ENST00000458174.4, ENST00000458174.5, ENST00000458174.6, IFLTD1, LMTD1_HUMAN, NM_001145728, Q8IY38, Q8N9Z9, uc320yzy.1, uc320yzy.2
UCSC ID: ENST00000458174.7_10
RefSeq Accession: NM_001145728.2
Protein: Q8N9Z9 (aka ILFT1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.