ID:LMX1B_HUMAN DESCRIPTION: RecName: Full=LIM homeobox transcription factor 1-beta; AltName: Full=LIM/homeobox protein 1.2; Short=LMX-1.2; AltName: Full=LIM/homeobox protein LMX1B; FUNCTION: Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Expressed in most tissues. Highest levels in testis, thyroid, duodenum, skeletal muscle, and pancreatic islets. DISEASE: Defects in LMX1B are the cause of nail-patella syndrome (NPS) [MIM:161200]; also known as onychoosteodysplasia. NPS is a disease that cause abnormal skeletal patterning and renal dysplasia. SIMILARITY: Contains 1 homeobox DNA-binding domain. SIMILARITY: Contains 2 LIM zinc-binding domains. SEQUENCE CAUTION: Sequence=CAH70294.1; Type=Erroneous initiation; Sequence=CAI40917.1; Type=Erroneous initiation; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/LMX1B";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60663
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0001701 in utero embryonic development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0009953 dorsal/ventral pattern formation GO:0030182 neuron differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0071542 dopaminergic neuron differentiation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
