ID:LYOX_HUMAN DESCRIPTION: RecName: Full=Protein-lysine 6-oxidase; EC=1.4.3.13; AltName: Full=Lysyl oxidase; Flags: Precursor; FUNCTION: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. CATALYTIC ACTIVITY: Peptidyl-L-lysyl-peptide + O(2) + H(2)O = peptidyl-allysyl-peptide + NH(3) + H(2)O(2). COFACTOR: Copper. COFACTOR: Contains 1 lysine tyrosylquinone (By similarity). INTERACTION: O95967:EFEMP2; NbExp=4; IntAct=EBI-3893481, EBI-743414; P15502:ELN; NbExp=2; IntAct=EBI-3893481, EBI-1222108; P35555:FBN1; NbExp=2; IntAct=EBI-3893481, EBI-2505934; SUBCELLULAR LOCATION: Secreted, extracellular space. TISSUE SPECIFICITY: Heart, placenta, skeletal muscle, kidney, lung and pancreas. PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. MISCELLANEOUS: The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via interaction with tropoelastin (By similarity). SIMILARITY: Belongs to the lysyl oxidase family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LOXID41191ch5q23.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P28300
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004720 protein-lysine 6-oxidase activity GO:0005507 copper ion binding GO:0005515 protein binding GO:0016491 oxidoreductase activity GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0046872 metal ion binding
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
