ID:LOXL4_HUMAN DESCRIPTION: RecName: Full=Lysyl oxidase homolog 4; EC=1.4.3.-; AltName: Full=Lysyl oxidase-like protein 4; AltName: Full=Lysyl oxidase-related protein C; Flags: Precursor; FUNCTION: May modulate the formation of a collagenous extracellular matrix. COFACTOR: Copper (By similarity). COFACTOR: Contains 1 lysine tyrosylquinone (By similarity). INTERACTION: Q15645:TRIP13; NbExp=3; IntAct=EBI-749562, EBI-358993; SUBCELLULAR LOCATION: Secreted, extracellular space (Potential). TISSUE SPECIFICITY: Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage. PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. SIMILARITY: Belongs to the lysyl oxidase family. SIMILARITY: Contains 4 SRCR domains. SEQUENCE CAUTION: Sequence=AAH07522.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LOXL4ID41193ch10q24.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96JB6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005044 scavenger receptor activity GO:0005507 copper ion binding GO:0005515 protein binding GO:0016491 oxidoreductase activity GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0046872 metal ion binding
Biological Process: GO:0006898 receptor-mediated endocytosis GO:0055114 oxidation-reduction process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
