ID:LPAR6_HUMAN DESCRIPTION: RecName: Full=Lysophosphatidic acid receptor 6; Short=LPA receptor 6; Short=LPA-6; AltName: Full=Oleoyl-L-alpha-lysophosphatidic acid receptor; AltName: Full=P2Y purinoceptor 5; Short=P2Y5; AltName: Full=Purinergic receptor 5; AltName: Full=RB intron encoded G-protein coupled receptor; FUNCTION: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes. DEVELOPMENTAL STAGE: Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway. DISEASE: Defects in LPAR6 are the cause of woolly hair autosomal recessive type 1 with or without hypotrichosis (ARWH1) [MIM:278150]. A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. DISEASE: Defects in LPAR6 are the cause of hypotrichosis type 8 (HYPT8) [MIM:278150]. A condition characterized by the presence of less than the normal amount of hair. Affected individuals show progressive hair loss, thinning of scalp hair since early childhood, sparse body hair, and sparse eyebrows and eyelashes in some cases. MISCELLANEOUS: This is a nested gene within intron 17 of the retinoblastoma gene. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. SEQUENCE CAUTION: Sequence=L11910; Type=Frameshift; Positions=31;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 142913 - YktB/PF0168-like 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on P43657
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0035025 positive regulation of Rho protein signal transduction GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
Cellular Component: GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0043231 intracellular membrane-bounded organelle
Descriptions from all associated GenBank mRNAs
BX647109 - Homo sapiens mRNA; cDNA DKFZp686C10196 (from clone DKFZp686C10196). AK123059 - Homo sapiens cDNA FLJ41064 fis, clone TRACH2001021, highly similar to P2Y PURINOCEPTOR 5. AK223389 - Homo sapiens mRNA for G-protein coupled purinergic receptor P2Y5 variant, clone: FCC107B01. BC040850 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 5, mRNA (cDNA clone MGC:49911 IMAGE:5180625), complete cds. BX537445 - Homo sapiens mRNA; cDNA DKFZp686B1664 (from clone DKFZp686B1664); complete cds. BX537392 - Homo sapiens mRNA; cDNA DKFZp313O1437 (from clone DKFZp313O1437); complete cds. BX537438 - Homo sapiens mRNA; cDNA DKFZp686P1665 (from clone DKFZp686P1665); complete cds. BC045651 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 5, mRNA (cDNA clone MGC:43555 IMAGE:5269149), complete cds. AK122856 - Homo sapiens cDNA FLJ16477 fis, clone BRSTN2013171, highly similar to P2Y purinoceptor 5. BC070295 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 5, mRNA (cDNA clone MGC:88290 IMAGE:6663864), complete cds. BC106756 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 5, mRNA (cDNA clone MGC:120358 IMAGE:40024517), complete cds. AF000546 - Homo sapiens purinergic receptor P2Y5 mRNA, complete cds. EU831916 - Synthetic construct Homo sapiens clone HAIB:100066945; DKFZo008B0423 purinergic receptor P2Y, G-protein coupled, 5 protein (P2RY5) gene, encodes complete protein. HQ995530 - Homo sapiens purinergic receptor P2Y G protein-coupled protein 5 (P2RY5) mRNA, complete cds. JF810890 - Homo sapiens lysophosphatidic acid receptor 6 (LPAR6) mRNA, complete cds. EU832010 - Synthetic construct Homo sapiens clone HAIB:100067039; DKFZo004B0424 purinergic receptor P2Y, G-protein coupled, 5 protein (P2RY5) gene, encodes complete protein. KJ892942 - Synthetic construct Homo sapiens clone ccsbBroadEn_02336 LPAR6 gene, encodes complete protein. KR711837 - Synthetic construct Homo sapiens clone CCSBHm_00031289 LPAR6 (LPAR6) mRNA, encodes complete protein. KR711838 - Synthetic construct Homo sapiens clone CCSBHm_00031291 LPAR6 (LPAR6) mRNA, encodes complete protein. KR711839 - Synthetic construct Homo sapiens clone CCSBHm_00031294 LPAR6 (LPAR6) mRNA, encodes complete protein. KR711840 - Synthetic construct Homo sapiens clone CCSBHm_00031297 LPAR6 (LPAR6) mRNA, encodes complete protein. AB464111 - Synthetic construct DNA, clone: pF1KB7145, Homo sapiens P2RY5 gene for purinergic receptor P2Y, G-protein coupled, 5, without stop codon, in Flexi system. BC054346 - Homo sapiens purinergic receptor P2Y, G-protein coupled, 5, mRNA (cDNA clone IMAGE:4479923), with apparent retained intron.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P43657 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
