Human Gene LRP11 (ENST00000239367.7_7) from GENCODE V47lift37
  Description: LDL receptor related protein 11 (from RefSeq NM_032832.6)
Gencode Transcript: ENST00000239367.7_7
Gencode Gene: ENSG00000120256.11_11
Transcript (Including UTRs)
   Position: hg19 chr6:150,139,893-150,185,495 Size: 45,603 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr6:150,141,685-150,185,156 Size: 43,472 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:150,139,893-150,185,495)mRNA (may differ from genome)Protein (500 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LRP11_HUMAN
DESCRIPTION: RecName: Full=Low-density lipoprotein receptor-related protein 11; Short=LRP-11; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
SIMILARITY: Belongs to the LDLR family.
SIMILARITY: Contains 1 LDL-receptor class A domain.
SIMILARITY: Contains 1 MANSC domain.
SIMILARITY: Contains 1 PKD domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.76 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 525.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -188.20339-0.555 Picture PostScript Text
3' UTR -402.301792-0.224 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023415 - LDLR_class-A_CS
IPR002172 - LDrepeatLR_classA_rpt
IPR013980 - MANSC
IPR011106 - MANSC_N
IPR022409 - PKD/Chitinase_dom
IPR000601 - PKD_dom

Pfam Domains:
PF00057 - Low-density lipoprotein receptor domain class A
PF07502 - MANEC domain

SCOP Domains:
49299 - PKD domain
57424 - LDL receptor-like module

ModBase Predicted Comparative 3D Structure on Q86VZ4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0051219 phosphoprotein binding

Biological Process:
GO:0009408 response to heat
GO:0009409 response to cold
GO:0009414 response to water deprivation
GO:0009612 response to mechanical stimulus
GO:0033555 multicellular organismal response to stress
GO:0035902 response to immobilization stress
GO:0042594 response to starvation

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF384614 - JP 2014500723-A/192117: Polycomb-Associated Non-Coding RNAs.
AJ420524 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 2004811.
BC043141 - Homo sapiens low density lipoprotein receptor-related protein 11, mRNA (cDNA clone MGC:41767 IMAGE:5286304), complete cds.
AK027641 - Homo sapiens cDNA FLJ14735 fis, clone NT2RP3002054.
JD183194 - Sequence 164218 from Patent EP1572962.
JD302570 - Sequence 283594 from Patent EP1572962.
JD278659 - Sequence 259683 from Patent EP1572962.
JD304857 - Sequence 285881 from Patent EP1572962.
JD314351 - Sequence 295375 from Patent EP1572962.
JD349301 - Sequence 330325 from Patent EP1572962.
JD453955 - Sequence 434979 from Patent EP1572962.
JD382396 - Sequence 363420 from Patent EP1572962.
AK299599 - Homo sapiens cDNA FLJ51289 complete cds, highly similar to Low-density lipoprotein receptor-related protein 11 precursor.
JD237117 - Sequence 218141 from Patent EP1572962.
JD046588 - Sequence 27612 from Patent EP1572962.
JD224127 - Sequence 205151 from Patent EP1572962.
JD433566 - Sequence 414590 from Patent EP1572962.
JD276354 - Sequence 257378 from Patent EP1572962.
JD509607 - Sequence 490631 from Patent EP1572962.
JD320391 - Sequence 301415 from Patent EP1572962.
JD277979 - Sequence 259003 from Patent EP1572962.
JD274013 - Sequence 255037 from Patent EP1572962.
AK223134 - Homo sapiens mRNA, low density lipoprotein receptor-related protein 11 variant, clone: KDN00404.
LF321587 - JP 2014500723-A/129090: Polycomb-Associated Non-Coding RNAs.
LF321585 - JP 2014500723-A/129088: Polycomb-Associated Non-Coding RNAs.
BC025239 - Homo sapiens low density lipoprotein receptor-related protein 11, mRNA (cDNA clone IMAGE:4858324), complete cds.
JD425542 - Sequence 406566 from Patent EP1572962.
JD453355 - Sequence 434379 from Patent EP1572962.
MA620191 - JP 2018138019-A/192117: Polycomb-Associated Non-Coding RNAs.
MA557164 - JP 2018138019-A/129090: Polycomb-Associated Non-Coding RNAs.
MA557162 - JP 2018138019-A/129088: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000239367.1, ENST00000239367.2, ENST00000239367.3, ENST00000239367.4, ENST00000239367.5, ENST00000239367.6, LRP11_HUMAN, NM_032832, Q5VYC0, Q86VZ4, Q96SN6, uc317efm.1, uc317efm.2
UCSC ID: ENST00000239367.7_7
RefSeq Accession: NM_032832.6
Protein: Q86VZ4 (aka LRP11_HUMAN or LR11_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.