Human Gene LRRC14 (ENST00000292524.6_4) from GENCODE V47lift37

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Description: leucine rich repeat containing 14, transcript variant 2 (from RefSeq NM_014665.4)
Gencode Transcript: ENST00000292524.6_4
Gencode Gene: ENSG00000160959.8_12
Transcript (Including UTRs)
Position: hg19 chr8:145,743,376-145,750,556 Size: 7,181 Total Exon Count: 4 Strand: +
Coding Region
Position: hg19 chr8:145,745,110-145,746,862 Size: 1,753 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:145,743,376-145,750,556)			mRNA (may differ from genome)		Protein (493 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: LRC14_HUMAN DESCRIPTION: RecName: Full=Leucine-rich repeat-containing protein 14; SIMILARITY: Belongs to the PRAME family. SIMILARITY: Contains 5 LRR (leucine-rich) repeats. SEQUENCE CAUTION: Sequence=BAA04946.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D000082 Acetaminophen D019327 Copper Sulfate D016572 Cyclosporine D012822 Silicon Dioxide D012999 Soman C044887 beta-methylcholine C018021 cobaltous chloride C045463 leflunomide C088658 zoledronic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 7.40 RPKM in Brain - Cerebellum Total median expression: 241.50 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-76.10	161	-0.473	Picture	PostScript	Text
3' UTR	-1711.40	3694	-0.463	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026292 - PRAME/Leu_rich_rep-con_p14

Pfam Domains:
PF00560 - Leucine Rich Repeat
PF13516 - Leucine Rich repeat

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on Q15048


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0019900 kinase binding Biological Process: GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0034122 negative regulation of toll-like receptor signaling pathway Cellular Component: GO:0005737 cytoplasm

Descriptions from all associated GenBank mRNAs


	AK289473 - Homo sapiens cDNA FLJ75566 complete cds, highly similar to Homo sapiens leucine rich repeat containing 14 (LRRC14), mRNA. BC011377 - Homo sapiens leucine rich repeat containing 14, mRNA (cDNA clone MGC:9269 IMAGE:3853673), complete cds. D25216 - Homo sapiens KIAA0014 mRNA. JD485140 - Sequence 466164 from Patent EP1572962. JD347009 - Sequence 328033 from Patent EP1572962. JD077922 - Sequence 58946 from Patent EP1572962. JD488224 - Sequence 469248 from Patent EP1572962. JD392122 - Sequence 373146 from Patent EP1572962. JD260927 - Sequence 241951 from Patent EP1572962. GQ129434 - Synthetic construct Homo sapiens clone HAIB:100068718; DKFZo004G0836 leucine rich repeat containing 14 protein (LRRC14) gene, partial cds. GQ129435 - Synthetic construct Homo sapiens clone HAIB:100068621; DKFZo008G0835 leucine rich repeat containing 14 protein (LRRC14) gene, complete cds. AB383704 - Synthetic construct DNA, clone: pF1KSDA0014, Homo sapiens LRRC14 gene for leucine-rich repeat-containing protein 14, complete cds, without stop codon, in Flexi system. CU679916 - Synthetic construct Homo sapiens gateway clone IMAGE:100019655 5' read LRRC14 mRNA. KJ898071 - Synthetic construct Homo sapiens clone ccsbBroadEn_07465 LRRC14 gene, encodes complete protein. DQ598542 - Homo sapiens piRNA piR-36608, complete sequence. JD200540 - Sequence 181564 from Patent EP1572962. JD453918 - Sequence 434942 from Patent EP1572962. JD302173 - Sequence 283197 from Patent EP1572962. DQ586075 - Homo sapiens piRNA piR-53187, complete sequence. JD251755 - Sequence 232779 from Patent EP1572962. JD266276 - Sequence 247300 from Patent EP1572962. JD477166 - Sequence 458190 from Patent EP1572962. JD469999 - Sequence 451023 from Patent EP1572962. JD286054 - Sequence 267078 from Patent EP1572962. JD053006 - Sequence 34030 from Patent EP1572962. JD246327 - Sequence 227351 from Patent EP1572962. JD099231 - Sequence 80255 from Patent EP1572962. JD056387 - Sequence 37411 from Patent EP1572962. JD157034 - Sequence 138058 from Patent EP1572962. JD390191 - Sequence 371215 from Patent EP1572962. JD124185 - Sequence 105209 from Patent EP1572962. JD122714 - Sequence 103738 from Patent EP1572962. JD386472 - Sequence 367496 from Patent EP1572962. JD186356 - Sequence 167380 from Patent EP1572962. JD216829 - Sequence 197853 from Patent EP1572962. JD144331 - Sequence 125355 from Patent EP1572962. JD187414 - Sequence 168438 from Patent EP1572962. JD116514 - Sequence 97538 from Patent EP1572962. JD339825 - Sequence 320849 from Patent EP1572962. JD271239 - Sequence 252263 from Patent EP1572962. JD055049 - Sequence 36073 from Patent EP1572962. JD525231 - Sequence 506255 from Patent EP1572962. JD078674 - Sequence 59698 from Patent EP1572962. JD445192 - Sequence 426216 from Patent EP1572962. DQ571700 - Homo sapiens piRNA piR-31812, complete sequence. DQ588833 - Homo sapiens piRNA piR-55945, complete sequence. DQ588834 - Homo sapiens piRNA piR-55946, complete sequence. JD296824 - Sequence 277848 from Patent EP1572962. JD044922 - Sequence 25946 from Patent EP1572962. JD389467 - Sequence 370491 from Patent EP1572962. JD416179 - Sequence 397203 from Patent EP1572962. JD537070 - Sequence 518094 from Patent EP1572962. JD309530 - Sequence 290554 from Patent EP1572962. JD227283 - Sequence 208307 from Patent EP1572962. JD393744 - Sequence 374768 from Patent EP1572962. JD325006 - Sequence 306030 from Patent EP1572962. JD404646 - Sequence 385670 from Patent EP1572962. JD251275 - Sequence 232299 from Patent EP1572962. JD109344 - Sequence 90368 from Patent EP1572962. JD402205 - Sequence 383229 from Patent EP1572962. JD363743 - Sequence 344767 from Patent EP1572962. JD452647 - Sequence 433671 from Patent EP1572962. JD371195 - Sequence 352219 from Patent EP1572962. JD467642 - Sequence 448666 from Patent EP1572962. JD045935 - Sequence 26959 from Patent EP1572962. JD486445 - Sequence 467469 from Patent EP1572962. JD336469 - Sequence 317493 from Patent EP1572962. JD406173 - Sequence 387197 from Patent EP1572962. JD458953 - Sequence 439977 from Patent EP1572962. JD168846 - Sequence 149870 from Patent EP1572962. JD542094 - Sequence 523118 from Patent EP1572962. JD186823 - Sequence 167847 from Patent EP1572962. JD216734 - Sequence 197758 from Patent EP1572962. JD391866 - Sequence 372890 from Patent EP1572962. JD079966 - Sequence 60990 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A8K0A8, D3DWM8, ENST00000292524.1, ENST00000292524.2, ENST00000292524.3, ENST00000292524.4, ENST00000292524.5, KIAA0014 , LRC14_HUMAN, LRRC14 , NM_014665, Q15048, uc317lbk.1, uc317lbk.2 UCSC ID: ENST00000292524.6_4 RefSeq Accession: NM_014665.4 Protein: Q15048 (aka LRC14_HUMAN or LR14_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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