ID:LSM2_HUMAN DESCRIPTION: RecName: Full=U6 snRNA-associated Sm-like protein LSm2; AltName: Full=Protein G7b; AltName: Full=Small nuclear ribonuclear protein D homolog; AltName: Full=snRNP core Sm-like protein Sm-x5; FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing. SUBUNIT: Identified in the spliceosome C complex. LSm subunits form a heteromer with a doughnut shape. INTERACTION: O15116:LSM1; NbExp=3; IntAct=EBI-347416, EBI-347619; P62310:LSM3; NbExp=8; IntAct=EBI-347416, EBI-348239; Q9UK45:LSM7; NbExp=4; IntAct=EBI-347416, EBI-348372; O95777:NAA38; NbExp=5; IntAct=EBI-347416, EBI-347779; Q9H9D4:ZNF408; NbExp=4; IntAct=EBI-347416, EBI-347633; SUBCELLULAR LOCATION: Nucleus (Potential). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the snRNP Sm proteins family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y333
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF182288 - Homo sapiens U6 snRNA-associated Sm-like protein LSm2 mRNA, complete cds. BC009192 - Homo sapiens LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae), mRNA (cDNA clone MGC:15227 IMAGE:3842537), complete cds. AF136977 - Homo sapiens snRNP core SM-like protein SM-x5 mRNA, complete cds. AJ245416 - Homo sapiens mRNA for G7b protein (G7b gene, located in the class III region of the major histocompatibility complex. JD375207 - Sequence 356231 from Patent EP1572962. JD245888 - Sequence 226912 from Patent EP1572962. AF196468 - Homo sapiens SMX5-like protein mRNA, complete cds. JD481070 - Sequence 462094 from Patent EP1572962. JD390261 - Sequence 371285 from Patent EP1572962. JD468782 - Sequence 449806 from Patent EP1572962. CR542146 - Homo sapiens full open reading frame cDNA clone RZPDo834F0523D for gene LSM2, LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae); complete cds, incl. stopcodon. KJ894459 - Synthetic construct Homo sapiens clone ccsbBroadEn_03853 LSM2 gene, encodes complete protein. DQ892903 - Synthetic construct clone IMAGE:100005533; FLH195258.01X; RZPDo839A06152D LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) (LSM2) gene, encodes complete protein. DQ896539 - Synthetic construct Homo sapiens clone IMAGE:100010999; FLH195254.01L; RZPDo839A06151D LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) (LSM2) gene, encodes complete protein. AB464333 - Synthetic construct DNA, clone: pF1KB6731, Homo sapiens LSM2 gene for U6 snRNA-associated Sm-like protein LSm2, without stop codon, in Flexi system. CR542157 - Homo sapiens full open reading frame cDNA clone RZPDo834D0124D for gene LSM2, LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae); complete cds, without stopcodon. JD258540 - Sequence 239564 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y333 (Reactome details) participates in the following event(s):
R-HSA-75083 ATAC spliceosome mediated 3' splice site cleavage, exon ligation R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-429978 Lsm1-7 Complex binds deadenylated mRNA R-HSA-429845 5' to 3' exoribonuclease hydrolyzes decapped mRNA R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-75081 Formation of AT-AC B Complex R-HSA-75082 ATAC spliceosome mediated Lariat formation,5' splice site cleavage R-HSA-75079 Formation of AT-AC C complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-429860 DCP1-DCP2 complex decaps mRNA R-HSA-72165 mRNA Splicing - Minor Pathway R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease R-HSA-72172 mRNA Splicing R-HSA-429914 Deadenylation-dependent mRNA decay R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
