Human Gene LTB4R (ENST00000345363.8_4) from GENCODE V47lift37
  Description: leukotriene B4 receptor, transcript variant 2 (from RefSeq NM_001143919.3)
Gencode Transcript: ENST00000345363.8_4
Gencode Gene: ENSG00000213903.9_9
Transcript (Including UTRs)
   Position: hg19 chr14:24,780,708-24,787,242 Size: 6,535 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr14:24,784,858-24,785,916 Size: 1,059 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:24,780,708-24,787,242)mRNA (may differ from genome)Protein (352 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LT4R1_HUMAN
DESCRIPTION: RecName: Full=Leukotriene B4 receptor 1; Short=LTB4-R 1; Short=LTB4-R1; AltName: Full=Chemoattractant receptor-like 1; AltName: Full=G-protein coupled receptor 16; AltName: Full=P2Y purinoceptor 7; Short=P2Y7;
FUNCTION: Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.
PTM: Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=AAB16747.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: LTB4R
Diseases sorted by gene-association score: image syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C089698 CP 105696
  • C063609 1,2-dimethyl-4-nitrobenzene
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
  • C082206 7-(3-(2-(cyclopropylmethyl)-3-methoxy-4-((methylamino)carbonyl)phenoxy)propoxy)-3,4-dihydro-8-propyl-2H-1-benzopyran-2-propanoic acid
  • D000082 Acetaminophen
  • D000643 Ammonium Chloride
  • D002251 Carbon Tetrachloride
  • D005419 Flavonoids
  • D005557 Formaldehyde
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 47.19 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 364.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -144.80318-0.455 Picture PostScript Text
3' UTR -424.701326-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR003981 - Leukotriene_B4_rcpt
IPR003983 - Leukotriene_B4_typ-1_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10328 - Serpentine type 7TM GPCR chemoreceptor Srx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q15722
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0001632 leukotriene B4 receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004974 leukotriene receptor activity
GO:0008528 G-protein coupled peptide receptor activity

Biological Process:
GO:0006936 muscle contraction
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0061737 leukotriene signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft


-  Descriptions from all associated GenBank mRNAs
  KJ904441 - Synthetic construct Homo sapiens clone ccsbBroadEn_13835 LTB4R gene, encodes complete protein.
AF277230 - Homo sapiens seven transmembrane receptor BLTR2 (BLTR2) mRNA, complete cds.
AK304169 - Homo sapiens cDNA FLJ53958 complete cds, highly similar to Leukotriene B4 receptor 2.
BC038437 - Homo sapiens leukotriene B4 receptor 2, mRNA (cDNA clone IMAGE:4753033).
AB032558 - Homo sapiens KPG_004 mRNA for G-protein coupled receptor, complete cds.
BC127643 - Homo sapiens leukotriene B4 receptor 2, mRNA (cDNA clone IMAGE:40116228), partial cds.
BC119674 - Homo sapiens leukotriene B4 receptor 2, mRNA (cDNA clone IMAGE:40116226), partial cds.
BC172240 - Synthetic construct Homo sapiens clone IMAGE:100068934, MGC:198945 leukotriene B4 receptor 2 (LTB4R2) mRNA, encodes complete protein.
BC172548 - Synthetic construct Homo sapiens clone IMAGE:100069242, MGC:199253 leukotriene B4 receptor 2 (LTB4R2) mRNA, encodes complete protein.
AB029892 - Homo sapiens hBLT2 mRNA for Leukotriene B4 receptor BLT2, complete cds.
AB044402 - Homo sapiens mRNA for LTB4 receptor JULF2, complete cds.
AF308571 - Homo sapiens hepatointestinal leukotriene B4 receptor mRNA, complete cds.
D89079 - Homo sapiens mRNA for leukotriene b4 receptor, complete cds.
U41070 - Human P2 purinergic receptor mRNA, complete cds.
D89078 - Homo sapiens mRNA for leukotriene b4 receptor, complete cds.
LF212572 - JP 2014500723-A/20075: Polycomb-Associated Non-Coding RNAs.
X98356 - H.sapiens mRNA for G protein-coupled receptor.
BC004545 - Homo sapiens leukotriene B4 receptor, mRNA (cDNA clone MGC:10388 IMAGE:3946189), complete cds.
LF210091 - JP 2014500723-A/17594: Polycomb-Associated Non-Coding RNAs.
JD156711 - Sequence 137735 from Patent EP1572962.
AB590455 - Synthetic construct DNA, clone: pFN21AB4905, Homo sapiens LTB4R gene for leukotriene B4 receptor, without stop codon, in Flexi system.
DQ893799 - Synthetic construct Homo sapiens clone IMAGE:100008259; FLH164502.01L; RZPDo839G12161D leukotriene B4 receptor (LTB4R) gene, encodes complete protein.
EU176177 - Synthetic construct Homo sapiens clone IMAGE:100006332; FLH164506.01X; RZPDo839G12162D leukotriene B4 receptor (LTB4R) gene, encodes complete protein.
CU678760 - Synthetic construct Homo sapiens gateway clone IMAGE:100023461 5' read LTB4R mRNA.
BT007267 - Homo sapiens leukotriene B4 receptor mRNA, complete cds.
JD233894 - Sequence 214918 from Patent EP1572962.
JD037150 - Sequence 18174 from Patent EP1572962.
JD144273 - Sequence 125297 from Patent EP1572962.
JD470838 - Sequence 451862 from Patent EP1572962.
JD444049 - Sequence 425073 from Patent EP1572962.
JD346830 - Sequence 327854 from Patent EP1572962.
JD215651 - Sequence 196675 from Patent EP1572962.
JD442218 - Sequence 423242 from Patent EP1572962.
LF334572 - JP 2014500723-A/142075: Polycomb-Associated Non-Coding RNAs.
MA448149 - JP 2018138019-A/20075: Polycomb-Associated Non-Coding RNAs.
MA445668 - JP 2018138019-A/17594: Polycomb-Associated Non-Coding RNAs.
MA570149 - JP 2018138019-A/142075: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q15722 (Reactome details) participates in the following event(s):

R-HSA-391941 BLT receptors can bind LTB4
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-391903 Eicosanoid ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: BLT, BLT1, BLTR, CMKRL1, ENST00000345363.1, ENST00000345363.2, ENST00000345363.3, ENST00000345363.4, ENST00000345363.5, ENST00000345363.6, ENST00000345363.7, GPR16, LT4R1_HUMAN, NM_001143919, P2RY7, Q13305, Q15722, Q53XV5, Q92641, Q9BSU5, uc317xff.1, uc317xff.2
UCSC ID: ENST00000345363.8_4
RefSeq Accession: NM_001143919.3
Protein: Q15722 (aka LT4R1_HUMAN or L4R1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.