Human Gene LTF (ENST00000231751.9_13) from GENCODE V47lift37
  Description: lactotransferrin, transcript variant 1 (from RefSeq NM_002343.6)
Gencode Transcript: ENST00000231751.9_13
Gencode Gene: ENSG00000012223.13_15
Transcript (Including UTRs)
   Position: hg19 chr3:46,477,136-46,506,395 Size: 29,260 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg19 chr3:46,477,686-46,506,357 Size: 28,672 Coding Exon Count: 17 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:46,477,136-46,506,395)mRNA (may differ from genome)Protein (710 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: LTF
Diseases sorted by gene-association score: mastitis (28), keratoconjunctivitis sicca (25), dry eye syndrome (19), dental caries (17), rheumatoid vasculitis (16), pouchitis (16), clostridium difficile colitis (15), superficial siderosis of the central nervous system (13), giant papillary conjunctivitis (13), shigellosis (12), oral candidiasis (11), gingivitis (11), specific granule deficiency (11), superficial siderosis (10), root caries (9), nasopharyngitis (9), dermatophytosis (9), suppurative periapical periodontitis (9), corneal dystrophy, gelatinous drop-like (9), radiation proctitis (8), nasopharyngeal disease (8), periodontitis 1, juvenile (8), felty syndrome (7), parotitis (7), acute diarrhea (7), haemophilus influenzae (7), proctitis (7), deafness, autosomal recessive 6 (6), iron deficiency anemia (6), aplasia of lacrimal and salivary glands (6), aseptic meningitis (5), chickenpox (5), gastrointestinal system disease (2), cholangitis, primary sclerosing (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 331.95 RPKM in Minor Salivary Gland
Total median expression: 502.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.5038-0.224 Picture PostScript Text
3' UTR -161.80550-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  U07643 - Human lactoferrin (HLF2) mRNA, complete cds.
BC015822 - Homo sapiens lactotransferrin, mRNA (cDNA clone MGC:13618 IMAGE:4251222), complete cds.
EU794669 - Homo sapiens epididymis luminal protein 110 (HEL110) mRNA, complete cds.
AK316330 - Homo sapiens cDNA, FLJ79229 complete cds, highly similar to Lactotransferrin precursor (EC 3.4.21.-).
M83202 - Human lactoferrin (HLF1) mRNA, complete cds.
AK290859 - Homo sapiens cDNA FLJ78440 complete cds, highly similar to Human mRNA for lactoferrin.
BC015823 - Homo sapiens lactotransferrin, mRNA (cDNA clone MGC:13619 IMAGE:4294752), complete cds.
X52941 - Human LTF mRNA for lactoferrin (lactotransferrin).
X53961 - Human mRNA for lactoferrin.
M93150 - Human lactoferrin mRNA, complete cds.
M18642 - Human lactoferrin gene, 3' end.
AK298035 - Homo sapiens cDNA FLJ58679 complete cds, highly similar to Lactotransferrin precursor (EC 3.4.21.-).
M83205 - Human HLF2-encoded protein mRNA, 3' end.
BC022347 - Homo sapiens lactotransferrin, mRNA (cDNA clone MGC:23800 IMAGE:4251058), complete cds.
AK292813 - Homo sapiens cDNA FLJ75480 complete cds, highly similar to Human mRNA for lactoferrin.
JD464390 - Sequence 445414 from Patent EP1572962.
AY165046 - Homo sapiens lactotransferrin precursor (LTF) mRNA, complete cds.
KF992208 - Homo sapiens lactoferrin mRNA, promoter region and complete cds.
AK303995 - Homo sapiens cDNA FLJ54839 complete cds, highly similar to Lactotransferrin precursor (EC 3.4.21.-).
AY493417 - Homo sapiens growth-inhibiting protein 12 (GIG12) mRNA, complete cds.
JD435990 - Sequence 417014 from Patent EP1572962.
KJ904501 - Synthetic construct Homo sapiens clone ccsbBroadEn_13895 LTF gene, encodes complete protein.
AF332168 - Homo sapiens lactoferrin precursor, mRNA, complete cds.
AY137470 - Homo sapiens lactoferrin mRNA, complete cds.
AY178998 - Homo sapiens lactoferrin mRNA, complete cds.
AY875691 - Homo sapiens lactoferrin mRNA, complete cds.
EU779935 - Homo sapiens lactoferrin mRNA, complete cds.
KT006756 - Homo sapiens lactoferrin (LTF) mRNA, complete cds.
AY360320 - Homo sapiens lactoferrin mRNA, complete cds, alternatively spliced.
KJ901559 - Synthetic construct Homo sapiens clone ccsbBroadEn_10953 LTF gene, encodes complete protein.
DQ892855 - Synthetic construct Homo sapiens clone IMAGE:100005485; FLH263563.01X; RZPDo839H0175D lactotransferrin (LTF) gene, encodes complete protein.
DQ896102 - Synthetic construct Homo sapiens clone IMAGE:100010562; FLH263681.01L; RZPDo839H0165D lactotransferrin (LTF) gene, encodes complete protein.
AB527812 - Synthetic construct DNA, clone: pF1KB9984, Homo sapiens LTF gene for lactotransferrin, without stop codon, in Flexi system.
AK093852 - Homo sapiens cDNA FLJ36533 fis, clone TRACH2004428, highly similar to Lactotransferrin precursor (EC 3.4.21.-).
AK126237 - Homo sapiens cDNA FLJ44249 fis, clone TKIDN2002632.
AK303889 - Homo sapiens cDNA FLJ59602 complete cds, highly similar to Lactotransferrin precursor (EC 3.4.21.-).
DQ522304 - Homo sapiens lactoferrin mRNA, partial cds.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_anthraxPathway - Anthrax Toxin Mechanism of Action

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000231751.1, ENST00000231751.2, ENST00000231751.3, ENST00000231751.4, ENST00000231751.5, ENST00000231751.6, ENST00000231751.7, ENST00000231751.8, HEL110 , NM_002343, uc317dva.1, uc317dva.2, V9HWI4, V9HWI4_HUMAN
UCSC ID: ENST00000231751.9_13
RefSeq Accession: NM_002343.6

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.