Human Gene LTF (ENST00000231751.9_13) from GENCODE V47lift37

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Description: lactotransferrin, transcript variant 1 (from RefSeq NM_002343.6)
Gencode Transcript: ENST00000231751.9_13
Gencode Gene: ENSG00000012223.13_15
Transcript (Including UTRs)
Position: hg19 chr3:46,477,136-46,506,395 Size: 29,260 Total Exon Count: 17 Strand: -
Coding Region
Position: hg19 chr3:46,477,686-46,506,357 Size: 28,672 Coding Exon Count: 17

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Pathways
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:46,477,136-46,506,395)			mRNA (may differ from genome)		Protein (710 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: LTF Diseases sorted by gene-association score: mastitis (28), keratoconjunctivitis sicca (25), dry eye syndrome (19), dental caries (17), rheumatoid vasculitis (16), pouchitis (16), clostridium difficile colitis (15), superficial siderosis of the central nervous system (13), giant papillary conjunctivitis (13), shigellosis (12), oral candidiasis (11), gingivitis (11), specific granule deficiency (11), superficial siderosis (10), root caries (9), nasopharyngitis (9), dermatophytosis (9), suppurative periapical periodontitis (9), corneal dystrophy, gelatinous drop-like (9), radiation proctitis (8), nasopharyngeal disease (8), periodontitis 1, juvenile (8), felty syndrome (7), parotitis (7), acute diarrhea (7), haemophilus influenzae (7), proctitis (7), deafness, autosomal recessive 6 (6), iron deficiency anemia (6), aplasia of lacrimal and salivary glands (6), aseptic meningitis (5), chickenpox (5), gastrointestinal system disease (2), cholangitis, primary sclerosing (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004054 Diethylstilbestrol D008070 Lipopolysaccharides D007631 Chlordecone D004958 Estradiol D019833 Genistein D007501 Iron D008345 Manganese D013629 Tamoxifen D014212 Tretinoin C009900 lipoteichoic acid C557531 1,7-diphenyl-5-heptene-3-one C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane C036990 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline C014036 4-hydroxyestradiol C041594 4-nonylphenol C080417 4-octylphenol D000082 Acetaminophen D016604 Aflatoxin B1 D000535 Aluminum D001151 Arsenic D001379 Azathioprine D001564 Benzo(a)pyrene D002211 Capsaicin D002857 Chromium D002945 Cisplatin D003300 Copper D003520 Cyclophosphamide D016572 Cyclosporine D003634 DDT D004126 Dimethylformamide D004997 Ethinyl Estradiol D004397 Fonofos D006861 Hydrogen Peroxide D008727 Methotrexate D008731 Methoxychlor D009151 Mustard Gas D009270 Naloxone D009532 Nickel D009569 Nitric Oxide D010126 Ozone D010278 Parathion D010713 Phosphatidylcholines D010840 Phytosterols D011239 Prednisolone D011374 Progesterone D012967 Sodium Dodecyl Sulfate D018038 Sodium Selenite D013481 Superoxides D016559 Tacrolimus D013749 Tetrachlorodibenzodioxin D013792 Thalidomide D013806 Theophylline D014028 Tobacco Smoke Pollution D015032 Zinc C016601 afimoxifene C006780 bisphenol A C033789 fenarimol C070081 fulvestrant C040641 genistin C051890 irinotecan C025256 nonylphenol C016340 o,p'-DDT C023036 perfluorooctanoic acid C009007 potassium persulfate C428725 pyridaben C017947 sodium arsenite C012568 terbufos C034697 transplatin

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 331.95 RPKM in Minor Salivary Gland Total median expression: 502.57 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-8.50	38	-0.224	Picture	PostScript	Text
3' UTR	-161.80	550	-0.294	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	U07643 - Human lactoferrin (HLF2) mRNA, complete cds. BC015822 - Homo sapiens lactotransferrin, mRNA (cDNA clone MGC:13618 IMAGE:4251222), complete cds. EU794669 - Homo sapiens epididymis luminal protein 110 (HEL110) mRNA, complete cds. AK316330 - Homo sapiens cDNA, FLJ79229 complete cds, highly similar to Lactotransferrin precursor (EC 3.4.21.-). M83202 - Human lactoferrin (HLF1) mRNA, complete cds. AK290859 - Homo sapiens cDNA FLJ78440 complete cds, highly similar to Human mRNA for lactoferrin. BC015823 - Homo sapiens lactotransferrin, mRNA (cDNA clone MGC:13619 IMAGE:4294752), complete cds. X52941 - Human LTF mRNA for lactoferrin (lactotransferrin). X53961 - Human mRNA for lactoferrin. M93150 - Human lactoferrin mRNA, complete cds. M18642 - Human lactoferrin gene, 3' end. AK298035 - Homo sapiens cDNA FLJ58679 complete cds, highly similar to Lactotransferrin precursor (EC 3.4.21.-). M83205 - Human HLF2-encoded protein mRNA, 3' end. BC022347 - Homo sapiens lactotransferrin, mRNA (cDNA clone MGC:23800 IMAGE:4251058), complete cds. AK292813 - Homo sapiens cDNA FLJ75480 complete cds, highly similar to Human mRNA for lactoferrin. JD464390 - Sequence 445414 from Patent EP1572962. AY165046 - Homo sapiens lactotransferrin precursor (LTF) mRNA, complete cds. KF992208 - Homo sapiens lactoferrin mRNA, promoter region and complete cds. AK303995 - Homo sapiens cDNA FLJ54839 complete cds, highly similar to Lactotransferrin precursor (EC 3.4.21.-). AY493417 - Homo sapiens growth-inhibiting protein 12 (GIG12) mRNA, complete cds. JD435990 - Sequence 417014 from Patent EP1572962. KJ904501 - Synthetic construct Homo sapiens clone ccsbBroadEn_13895 LTF gene, encodes complete protein. AF332168 - Homo sapiens lactoferrin precursor, mRNA, complete cds. AY137470 - Homo sapiens lactoferrin mRNA, complete cds. AY178998 - Homo sapiens lactoferrin mRNA, complete cds. AY875691 - Homo sapiens lactoferrin mRNA, complete cds. EU779935 - Homo sapiens lactoferrin mRNA, complete cds. KT006756 - Homo sapiens lactoferrin (LTF) mRNA, complete cds. AY360320 - Homo sapiens lactoferrin mRNA, complete cds, alternatively spliced. KJ901559 - Synthetic construct Homo sapiens clone ccsbBroadEn_10953 LTF gene, encodes complete protein. DQ892855 - Synthetic construct Homo sapiens clone IMAGE:100005485; FLH263563.01X; RZPDo839H0175D lactotransferrin (LTF) gene, encodes complete protein. DQ896102 - Synthetic construct Homo sapiens clone IMAGE:100010562; FLH263681.01L; RZPDo839H0165D lactotransferrin (LTF) gene, encodes complete protein. AB527812 - Synthetic construct DNA, clone: pF1KB9984, Homo sapiens LTF gene for lactotransferrin, without stop codon, in Flexi system. AK093852 - Homo sapiens cDNA FLJ36533 fis, clone TRACH2004428, highly similar to Lactotransferrin precursor (EC 3.4.21.-). AK126237 - Homo sapiens cDNA FLJ44249 fis, clone TKIDN2002632. AK303889 - Homo sapiens cDNA FLJ59602 complete cds, highly similar to Lactotransferrin precursor (EC 3.4.21.-). DQ522304 - Homo sapiens lactoferrin mRNA, partial cds.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_anthraxPathway - Anthrax Toxin Mechanism of Action

Other Names for This Gene


	Alternate Gene Symbols: ENST00000231751.1, ENST00000231751.2, ENST00000231751.3, ENST00000231751.4, ENST00000231751.5, ENST00000231751.6, ENST00000231751.7, ENST00000231751.8, HEL110 , NM_002343, uc317dva.1, uc317dva.2, V9HWI4, V9HWI4_HUMAN UCSC ID: ENST00000231751.9_13 RefSeq Accession: NM_002343.6

Gene Model Information


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Methods, Credits, and Use Restrictions


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