Human Gene LUC7L (ENST00000293872.13_8) from GENCODE V47lift37
  Description: LUC7 like, transcript variant 2 (from RefSeq NM_201412.3)
Gencode Transcript: ENST00000293872.13_8
Gencode Gene: ENSG00000007392.17_17
Transcript (Including UTRs)
   Position: hg19 chr16:238,989-279,448 Size: 40,460 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr16:239,197-279,338 Size: 40,142 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:238,989-279,448)mRNA (may differ from genome)Protein (371 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LUC7L_HUMAN
DESCRIPTION: RecName: Full=Putative RNA-binding protein Luc7-like 1; AltName: Full=Putative SR protein LUC7B1; AltName: Full=SR+89;
FUNCTION: May bind to RNA via its Arg/Ser-rich domain.
INTERACTION: Q9UBC1:NFKBIL1; NbExp=1; IntAct=EBI-473747, EBI-1043728; Q15287:RNPS1; NbExp=1; IntAct=EBI-473747, EBI-395959;
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the Luc7 family.
SIMILARITY: Contains 1 C2H2-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.37 RPKM in Thyroid
Total median expression: 1148.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.00110-0.355 Picture PostScript Text
3' UTR -37.80208-0.182 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004882 - LUC7-rel

Pfam Domains:
PF03194 - LUC7 N_terminus

ModBase Predicted Comparative 3D Structure on Q9NQ29
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0050733 RS domain binding

Biological Process:
GO:0006376 mRNA splice site selection
GO:0045843 negative regulation of striated muscle tissue development

Cellular Component:
GO:0005634 nucleus
GO:0005685 U1 snRNP
GO:0071004 U2-type prespliceosome


-  Descriptions from all associated GenBank mRNAs
  BC065198 - Homo sapiens LUC7-like (S. cerevisiae), mRNA (cDNA clone MGC:74654 IMAGE:5212471), complete cds.
AJ404326 - Homo sapiens SR+89 gene.
AK001093 - Homo sapiens cDNA FLJ10231 fis, clone HEMBB1000226, weakly similar to PUTATIVE PRE-MRNA SPLICING FACTOR ATP-DEPENDENT RNA HELICASE EEED8.5.
LF385174 - JP 2014500723-A/192677: Polycomb-Associated Non-Coding RNAs.
AY005111 - Homo sapiens putative SR protein LUC7B1 mRNA, complete cds, alternatively spliced.
BX647161 - Homo sapiens mRNA; cDNA DKFZp686O22196 (from clone DKFZp686O22196).
AK223084 - Homo sapiens mRNA for LUC7-like isoform b variant, clone: KAT01912.
HQ448098 - Synthetic construct Homo sapiens clone IMAGE:100071478; CCSB012182_01 LUC7-like (S. cerevisiae) (LUC7L) gene, encodes complete protein.
KJ902859 - Synthetic construct Homo sapiens clone ccsbBroadEn_12253 LUC7L gene, encodes complete protein.
AB528653 - Synthetic construct DNA, clone: pF1KB6551, Homo sapiens LUC7L gene for LUC7-like protein, without stop codon, in Flexi system.
BC003194 - Homo sapiens LUC7-like (S. cerevisiae), mRNA (cDNA clone MGC:988 IMAGE:3536109), complete cds.
KJ894237 - Synthetic construct Homo sapiens clone ccsbBroadEn_03631 LUC7L gene, encodes complete protein.
CU688020 - Synthetic construct Homo sapiens gateway clone IMAGE:100021687 5' read LUC7L mRNA.
CU678436 - Synthetic construct Homo sapiens gateway clone IMAGE:100018945 5' read LUC7L mRNA.
MA620751 - JP 2018138019-A/192677: Polycomb-Associated Non-Coding RNAs.
AK097974 - Homo sapiens cDNA FLJ40655 fis, clone THYMU2019021, highly similar to Homo sapiens SR+89 gene.
Z84716 - Human DNA sequence from cDNA 16pHQG;16 from chromosome 16p13.3.

-  Other Names for This Gene
  Alternate Gene Symbols: B8ZZ13, ENST00000293872.1, ENST00000293872.10, ENST00000293872.11, ENST00000293872.12, ENST00000293872.2, ENST00000293872.3, ENST00000293872.4, ENST00000293872.5, ENST00000293872.6, ENST00000293872.7, ENST00000293872.8, ENST00000293872.9, LUC7L1, LUC7L_HUMAN, NM_201412, Q96S32, Q9NPH4, Q9NQ29, uc317lfd.1, uc317lfd.2
UCSC ID: ENST00000293872.13_8
RefSeq Accession: NM_201412.3
Protein: Q9NQ29 (aka LUC7L_HUMAN or L7L1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.