Human Gene LUC7L2 (ENST00000354926.9_4) from GENCODE V47lift37
  Description: LUC7 like 2, pre-mRNA splicing factor, transcript variant 1 (from RefSeq NM_016019.5)
Gencode Transcript: ENST00000354926.9_4
Gencode Gene: ENSG00000146963.18_8
Transcript (Including UTRs)
   Position: hg19 chr7:139,044,640-139,108,200 Size: 63,561 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr7:139,045,008-139,107,086 Size: 62,079 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:139,044,640-139,108,200)mRNA (may differ from genome)Protein (392 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LC7L2_HUMAN
DESCRIPTION: RecName: Full=Putative RNA-binding protein Luc7-like 2;
FUNCTION: May bind to RNA via its Arg/Ser-rich domain.
SUBUNIT: Interacts with SCNM1 (By similarity).
INTERACTION: Q15287:RNPS1; NbExp=1; IntAct=EBI-352851, EBI-395959; P61981:YWHAG; NbExp=1; IntAct=EBI-352851, EBI-359832; P27348:YWHAQ; NbExp=1; IntAct=EBI-352851, EBI-359854;
SUBCELLULAR LOCATION: Nucleus speckle (By similarity). Nucleus, nucleoplasm (By similarity). Note=Colocalizes with SCNM1 and SNRNP70 in nuclear speckles (By similarity).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the Luc7 family.
SIMILARITY: Contains 1 C2H2-type zinc finger.
SEQUENCE CAUTION: Sequence=AAD34069.1; Type=Frameshift; Positions=388;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.65 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 332.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -172.90368-0.470 Picture PostScript Text
3' UTR -266.401114-0.239 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004882 - LUC7-rel

Pfam Domains:
PF03194 - LUC7 N_terminus

ModBase Predicted Comparative 3D Structure on Q9Y383
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGD  WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding

Biological Process:
GO:0006376 mRNA splice site selection

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005685 U1 snRNP
GO:0016607 nuclear speck
GO:0071004 U2-type prespliceosome


-  Descriptions from all associated GenBank mRNAs
  AK298166 - Homo sapiens cDNA FLJ55994 complete cds, highly similar to RNA-binding protein Luc7-like 2.
AK297642 - Homo sapiens cDNA FLJ55988 complete cds, highly similar to RNA-binding protein Luc7-like 2.
LF384098 - JP 2014500723-A/191601: Polycomb-Associated Non-Coding RNAs.
AK093864 - Homo sapiens cDNA FLJ36545 fis, clone TRACH2006670, highly similar to RNA-binding protein Luc7-like 2.
AK001519 - Homo sapiens cDNA FLJ10657 fis, clone NT2RP2006043, weakly similar to SPLICING FACTOR, ARGININE/SERINE-RICH 4.
BC042625 - Homo sapiens LUC7-like 2 (S. cerevisiae), mRNA (cDNA clone MGC:35315 IMAGE:5178074), complete cds.
BC050708 - Homo sapiens LUC7-like 2 (S. cerevisiae), mRNA (cDNA clone MGC:60313 IMAGE:6500791), complete cds.
BC017163 - Homo sapiens LUC7-like 2 (S. cerevisiae), mRNA (cDNA clone MGC:8819 IMAGE:3920377), complete cds.
AK001476 - Homo sapiens cDNA FLJ10614 fis, clone NT2RP2005436, weakly similar to SPLICING FACTOR, ARGININE/SERINE-RICH 4.
BC056886 - Homo sapiens LUC7-like 2 (S. cerevisiae), mRNA (cDNA clone MGC:65020 IMAGE:6147116), complete cds.
AK022895 - Homo sapiens cDNA FLJ12833 fis, clone NT2RP2003157, weakly similar to SPLICING FACTOR, ARGININE/SERINE-RICH 4.
AB528652 - Synthetic construct DNA, clone: pF1KB6550, Homo sapiens LUC7L2 gene for LUC7-like protein 2, without stop codon, in Flexi system.
EU832106 - Synthetic construct Homo sapiens clone HAIB:100067135; DKFZo008B0825 LUC7-like 2 (S. cerevisiae) protein (LUC7L2) gene, encodes complete protein.
EU832200 - Synthetic construct Homo sapiens clone HAIB:100067229; DKFZo004B0826 LUC7-like 2 (S. cerevisiae) protein (LUC7L2) gene, encodes complete protein.
CU677843 - Synthetic construct Homo sapiens gateway clone IMAGE:100017165 5' read LUC7L2 mRNA.
HQ448242 - Synthetic construct Homo sapiens clone IMAGE:100071643; CCSB000258_01 LUC7-like 2 (S. cerevisiae) (LUC7L2) gene, encodes complete protein.
KJ893955 - Synthetic construct Homo sapiens clone ccsbBroadEn_03349 LUC7L2 gene, encodes complete protein.
AF151832 - Homo sapiens CGI-74 protein mRNA, complete cds.
AF151817 - Homo sapiens CGI-59 protein mRNA, complete cds.
AK095839 - Homo sapiens cDNA FLJ38520 fis, clone HCHON2000781, weakly similar to Cisplatin resistance-associated overexpressed protein.
AK092044 - Homo sapiens cDNA FLJ34725 fis, clone MESAN2005958, highly similar to RNA-binding protein Luc7-like 2.
MA619675 - JP 2018138019-A/191601: Polycomb-Associated Non-Coding RNAs.
AK094081 - Homo sapiens cDNA FLJ36762 fis, clone UTERU2018955, highly similar to RNA-binding protein Luc7-like 2.
BC041001 - Homo sapiens LUC7-like 2 (S. cerevisiae), mRNA (cDNA clone IMAGE:5273893).
JD508848 - Sequence 489872 from Patent EP1572962.
JD263959 - Sequence 244983 from Patent EP1572962.
JD382755 - Sequence 363779 from Patent EP1572962.
JD154855 - Sequence 135879 from Patent EP1572962.
JD137171 - Sequence 118195 from Patent EP1572962.
JD058839 - Sequence 39863 from Patent EP1572962.
JD521116 - Sequence 502140 from Patent EP1572962.
JD379297 - Sequence 360321 from Patent EP1572962.
JD261339 - Sequence 242363 from Patent EP1572962.
JD525082 - Sequence 506106 from Patent EP1572962.
JD248240 - Sequence 229264 from Patent EP1572962.
JD359754 - Sequence 340778 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B7Z500, CGI-59, CGI-74, ENST00000354926.1, ENST00000354926.2, ENST00000354926.3, ENST00000354926.4, ENST00000354926.5, ENST00000354926.6, ENST00000354926.7, ENST00000354926.8, LC7L2_HUMAN, NM_016019, Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1, Q9Y383, uc317ywc.1, uc317ywc.2
UCSC ID: ENST00000354926.9_4
RefSeq Accession: NM_016019.5
Protein: Q9Y383 (aka LC7L2_HUMAN or L7L2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.