Human Gene LUC7L3 (ENST00000505658.6_6) from GENCODE V47lift37
  Description: LUC7 like 3 pre-mRNA splicing factor, transcript variant 1 (from RefSeq NM_016424.5)
Gencode Transcript: ENST00000505658.6_6
Gencode Gene: ENSG00000108848.16_16
Transcript (Including UTRs)
   Position: hg19 chr17:48,796,964-48,833,580 Size: 36,617 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr17:48,797,094-48,828,022 Size: 30,929 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:48,796,964-48,833,580)mRNA (may differ from genome)Protein (432 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LC7L3_HUMAN
DESCRIPTION: RecName: Full=Luc7-like protein 3; AltName: Full=Cisplatin resistance-associated-overexpressed protein; AltName: Full=Luc7A; AltName: Full=Okadaic acid-inducible phosphoprotein OA48-18; AltName: Full=cAMP regulatory element-associated protein 1; Short=CRE-associated protein 1; Short=CREAP-1;
FUNCTION: Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.
SUBUNIT: May interact with SFRS1 and form homodimers. Interacts with JMJD6 and RBM25. Interacts with RSRC1 (via Arg/Ser-rich domain).
INTERACTION: Q15287:RNPS1; NbExp=1; IntAct=EBI-395671, EBI-395959;
SUBCELLULAR LOCATION: Nucleus speckle. Note=The subnuclear localization is affected by cisplatin.
TISSUE SPECIFICITY: Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in fetal tissues, including brain, heart, kidney, thymus and lung.
PTM: Phosphorylated in vitro by SRPK1, SRPK2 and CLK1. Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the Luc7 family.
SEQUENCE CAUTION: Sequence=AAC79807.1; Type=Erroneous translation; Note=Erroneous CDS prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 125.79 RPKM in Brain - Cerebellum
Total median expression: 2094.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.10130-0.455 Picture PostScript Text
3' UTR -1375.705558-0.248 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004882 - LUC7-rel

Pfam Domains:
PF03194 - LUC7 N_terminus

ModBase Predicted Comparative 3D Structure on O95232
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding

Biological Process:
GO:0006376 mRNA splice site selection
GO:0006397 mRNA processing
GO:0008380 RNA splicing

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005685 U1 snRNP
GO:0016607 nuclear speck
GO:0071004 U2-type prespliceosome


-  Descriptions from all associated GenBank mRNAs
  AK290540 - Homo sapiens cDNA FLJ77715 complete cds, highly similar to Homo sapiens cisplatin resistance-associated overexpressed protein(LUC7A), mRNA.
AK225980 - Homo sapiens mRNA for cisplatin resistance-associated overexpressed protein variant, clone: FCC112B02.
AK023672 - Homo sapiens cDNA FLJ13610 fis, clone PLACE1010761, highly similar to Cisplatin resistance-associated overexpressed protein.
BC047043 - Homo sapiens cisplatin resistance-associated overexpressed protein, mRNA (cDNA clone IMAGE:4518856), partial cds.
BC056409 - Homo sapiens cisplatin resistance-associated overexpressed protein, mRNA (cDNA clone IMAGE:6195884), complete cds.
BC002925 - Homo sapiens cisplatin resistance-associated overexpressed protein, mRNA (cDNA clone IMAGE:3952783), partial cds.
AB034205 - Homo sapiens mRNA for cisplatin resistance-associated overexpressed protein, complete cds.
DQ013876 - Homo sapiens cAMP regulatory element associated protein 1 mRNA, complete cds.
AK295983 - Homo sapiens cDNA FLJ59548 complete cds, highly similar to Cisplatin resistance-associated overexpressed protein.
AK001925 - Homo sapiens cDNA FLJ11063 fis, clone PLACE1004814, weakly similar to SPLICING FACTOR, ARGININE/SERINE-RICH 4.
BC000604 - Homo sapiens mRNA similar to cisplatin resistance-associated overexpressed protein (cDNA clone IMAGE:3346964).
BC156954 - Synthetic construct Homo sapiens clone IMAGE:100063584, MGC:190819 cisplatin resistance-associated overexpressed protein (CROP) mRNA, encodes complete protein.
KJ902621 - Synthetic construct Homo sapiens clone ccsbBroadEn_12015 LUC7L3 gene, encodes complete protein.
AF147357 - Homo sapiens full length insert cDNA clone YB47A10.
AF069250 - Homo sapiens okadaic acid-inducible phosphoprotein (OA48-18) mRNA, complete cds.
JD409416 - Sequence 390440 from Patent EP1572962.
BC061896 - Homo sapiens cisplatin resistance-associated overexpressed protein, mRNA (cDNA clone IMAGE:4516016).
JD446211 - Sequence 427235 from Patent EP1572962.
JD336933 - Sequence 317957 from Patent EP1572962.
AK027723 - Homo sapiens cDNA FLJ14817 fis, clone OVARC1000113.
JD062191 - Sequence 43215 from Patent EP1572962.
JD024373 - Sequence 5397 from Patent EP1572962.
JD232236 - Sequence 213260 from Patent EP1572962.
JD053386 - Sequence 34410 from Patent EP1572962.
AL050121 - Homo sapiens mRNA; cDNA DKFZp586D091 (from clone DKFZp586D091).
JD174271 - Sequence 155295 from Patent EP1572962.
JD298948 - Sequence 279972 from Patent EP1572962.
JD160215 - Sequence 141239 from Patent EP1572962.
JD172204 - Sequence 153228 from Patent EP1572962.
JD309911 - Sequence 290935 from Patent EP1572962.
JD347311 - Sequence 328335 from Patent EP1572962.
JD063537 - Sequence 44561 from Patent EP1572962.
JD088996 - Sequence 70020 from Patent EP1572962.
JD346272 - Sequence 327296 from Patent EP1572962.
JD287108 - Sequence 268132 from Patent EP1572962.
JD304205 - Sequence 285229 from Patent EP1572962.
JD025126 - Sequence 6150 from Patent EP1572962.
JD032784 - Sequence 13808 from Patent EP1572962.
JD030535 - Sequence 11559 from Patent EP1572962.
JD428812 - Sequence 409836 from Patent EP1572962.
AK091489 - Homo sapiens cDNA FLJ34170 fis, clone FCBBF3015396.
AK090674 - Homo sapiens cDNA FLJ33355 fis, clone BRACE2005151.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KN54, CREAP1, CROP, D3DTY1, ENST00000505658.1, ENST00000505658.2, ENST00000505658.3, ENST00000505658.4, ENST00000505658.5, LC7L3_HUMAN, NM_016424, O48, O95232, Q6PHR9, Q9NUY0, Q9P2S7, uc323abi.1, uc323abi.2
UCSC ID: ENST00000505658.6_6
RefSeq Accession: NM_016424.5
Protein: O95232 (aka LC7L3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.