ID:LYL1_HUMAN DESCRIPTION: RecName: Full=Protein lyl-1; AltName: Full=Class A basic helix-loop-helix protein 18; Short=bHLHa18; AltName: Full=Lymphoblastic leukemia-derived sequence 1; SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. SUBCELLULAR LOCATION: Nucleus (Potential). DISEASE: Note=A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain. SEQUENCE CAUTION: Sequence=AAA88084.1; Type=Erroneous initiation; Sequence=AAA88085.1; Type=Erroneous initiation; Sequence=AAA92488.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LYL1ID51ch19p13.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P12980
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0005515 protein binding GO:0046983 protein dimerization activity
Biological Process: GO:0001955 blood vessel maturation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0030183 B cell differentiation GO:0045893 positive regulation of transcription, DNA-templated GO:0060216 definitive hemopoiesis
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
