Human Gene LYPLA1 (ENST00000316963.8_7) from GENCODE V47lift37
  Description: lysophospholipase 1, transcript variant 1 (from RefSeq NM_006330.4)
Gencode Transcript: ENST00000316963.8_7
Gencode Gene: ENSG00000120992.18_10
Transcript (Including UTRs)
   Position: hg19 chr8:54,958,927-55,014,507 Size: 55,581 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr8:54,960,625-55,014,383 Size: 53,759 Coding Exon Count: 9 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:54,958,927-55,014,507)mRNA (may differ from genome)Protein (230 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.69 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 478.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.90124-0.556 Picture PostScript Text
3' UTR -369.501698-0.218 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003140 - PLipase/COase/thioEstase

Pfam Domains:
PF02230 - Phospholipase/Carboxylesterase

SCOP Domains:
53474 - alpha/beta-Hydrolases

ModBase Predicted Comparative 3D Structure on Q6IAQ1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008474 palmitoyl-(protein) hydrolase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0002084 protein depalmitoylation
GO:0042997 negative regulation of Golgi to plasma membrane protein transport

Cellular Component:
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AF035293 - Homo sapiens clone 23797 and 23917 mRNA, partial cds.
AF081281 - Homo sapiens lysophospholipase (LPL1) mRNA, complete cds.
JD368561 - Sequence 349585 from Patent EP1572962.
JD247752 - Sequence 228776 from Patent EP1572962.
JD147116 - Sequence 128140 from Patent EP1572962.
JD324018 - Sequence 305042 from Patent EP1572962.
JD053578 - Sequence 34602 from Patent EP1572962.
AK298206 - Homo sapiens cDNA FLJ52008 complete cds, highly similar to Acyl-protein thioesterase 1 (EC 3.1.2.-).
JD236613 - Sequence 217637 from Patent EP1572962.
JD083604 - Sequence 64628 from Patent EP1572962.
JD166610 - Sequence 147634 from Patent EP1572962.
BC010397 - Homo sapiens lysophospholipase I, mRNA (cDNA clone MGC:13688 IMAGE:4109335), complete cds.
AF077198 - Homo sapiens lysophospholipase mRNA, complete cds.
AF077199 - Homo sapiens lysophospholipase isoform mRNA, complete cds.
BC008652 - Homo sapiens lysophospholipase I, mRNA (cDNA clone MGC:9121 IMAGE:3865775), complete cds.
AF052112 - Homo sapiens clone 23753 mRNA sequence.
JD561936 - Sequence 542960 from Patent EP1572962.
AK296257 - Homo sapiens cDNA FLJ60607 complete cds, highly similar to Acyl-protein thioesterase 1 (EC 3.1.2.-).
AK289400 - Homo sapiens cDNA FLJ78542 complete cds, highly similar to Homo sapiens lysophospholipase I (LYPLA1), mRNA.
JD181209 - Sequence 162233 from Patent EP1572962.
AF291053 - Homo sapiens acyl-protein thioesterase-1 mRNA, complete cds.
AK313739 - Homo sapiens cDNA, FLJ94339, Homo sapiens lysophospholipase I (LYPLA1), mRNA.
CU679013 - Synthetic construct Homo sapiens gateway clone IMAGE:100016831 5' read LYPLA1 mRNA.
CR457103 - Homo sapiens full open reading frame cDNA clone RZPDo834G067D for gene LYPLA1, lysophospholipase I; complete cds, incl. stopcodon.
DQ891527 - Synthetic construct clone IMAGE:100004157; FLH177735.01X; RZPDo839D06126D lysophospholipase I (LYPLA1) gene, encodes complete protein.
DQ894717 - Synthetic construct Homo sapiens clone IMAGE:100009177; FLH177731.01L; RZPDo839D06125D lysophospholipase I (LYPLA1) gene, encodes complete protein.
KJ898211 - Synthetic construct Homo sapiens clone ccsbBroadEn_07605 LYPLA1 gene, encodes complete protein.
AK307277 - Homo sapiens cDNA, FLJ97225.
JD476315 - Sequence 457339 from Patent EP1572962.
JD227677 - Sequence 208701 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000316963.1, ENST00000316963.2, ENST00000316963.3, ENST00000316963.4, ENST00000316963.5, ENST00000316963.6, ENST00000316963.7, hCG_1983522 , LYPLA1 , NM_006330, Q6IAQ1, Q6IAQ1_HUMAN, uc317qdc.1, uc317qdc.2
UCSC ID: ENST00000316963.8_7
RefSeq Accession: NM_006330.4
Protein: Q6IAQ1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.