Human Gene LZTR1 (ENST00000646124.2_5) from GENCODE V47lift37
  Description: leucine zipper like transcription regulator 1 (from RefSeq NM_006767.4)
Gencode Transcript: ENST00000646124.2_5
Gencode Gene: ENSG00000099949.22_18
Transcript (Including UTRs)
   Position: hg19 chr22:21,336,586-21,353,321 Size: 16,736 Total Exon Count: 21 Strand: +
Coding Region
   Position: hg19 chr22:21,336,661-21,351,637 Size: 14,977 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:21,336,586-21,353,321)mRNA (may differ from genome)Protein (840 aa)
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-  Comments and Description Text from UniProtKB
  ID: LZTR1_HUMAN
DESCRIPTION: RecName: Full=Leucine-zipper-like transcriptional regulator 1; Short=LZTR-1;
FUNCTION: Probable transcriptional regulator that may play a crucial role in embryogenesis.
DEVELOPMENTAL STAGE: Expressed in fetal brain, heart, kidney, liver and lung.
SIMILARITY: Contains 2 BTB (POZ) domains.
SIMILARITY: Contains 6 Kelch repeats.
SEQUENCE CAUTION: Sequence=BAA07508.1; Type=Frameshift; Positions=16, 69, 222;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: LZTR1
Diseases sorted by gene-association score: schwannomatosis-2* (1379), noonan syndrome 10* (1229), lztr1-related noonan syndrome* (500), giant cell glioblastoma* (175), gliosarcoma* (143), noonan syndrome 1* (107), schwannomatosis* (41), digeorge syndrome (14), nervous system benign neoplasm (9), chromosome 22q11.2 microduplication syndrome (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.2075-0.496 Picture PostScript Text
3' UTR -743.901684-0.442 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR015915 - Kelch-typ_b-propeller
IPR006652 - Kelch_1

Pfam Domains:
PF00651 - BTB/POZ domain
PF01344 - Kelch motif
PF07646 - Kelch motif
PF13415 - Galactose oxidase, central domain
PF13418 - Galactose oxidase, central domain
PF13854 - Kelch motif
PF13964 - Kelch motif

SCOP Domains:
117281 - Kelch motif
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
89372 - Fucose-specific lectin
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
82171 - DPP6 N-terminal domain-like
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q8N653
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003700 transcription factor activity, sequence-specific DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0009653 anatomical structure morphogenesis

Cellular Component:
GO:0005794 Golgi apparatus


-  Descriptions from all associated GenBank mRNAs
  AK127080 - Homo sapiens cDNA FLJ45137 fis, clone BRAWH3038827, highly similar to Homo sapiens leucine-zipper-like transcriptional regulator, 1 (LZTR1).
AK310747 - Homo sapiens cDNA, FLJ17789.
AK296347 - Homo sapiens cDNA FLJ53345 complete cds, highly similar to Leucine-zipper-like transcriptional regulator1.
CT841521 - Homo sapiens LZTR1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.LZTR1).
BC026214 - Homo sapiens leucine-zipper-like transcription regulator 1, mRNA (cDNA clone MGC:21205 IMAGE:4399716), complete cds.
GQ900956 - Homo sapiens clone HEL-T-68 epididymis secretory sperm binding protein mRNA, complete cds.
AB385248 - Synthetic construct DNA, clone: pF1KB9494, Homo sapiens LZTR1 gene for leucine-zipper-like transcriptional regulator 1, complete cds, without stop codon, in Flexi system.
CU013401 - Homo sapiens LZTR1, mRNA (cDNA clone IMAGE:100000474), complete cds, without stop codon, in Gateway system.
CU013113 - Homo sapiens LZTR1, mRNA (cDNA clone IMAGE:100000570), complete cds, with stop codon, in Gateway system.
D38496 - Homo sapiens mRNA for LZTR-1, complete cds.
JD164320 - Sequence 145344 from Patent EP1572962.
JD307380 - Sequence 288404 from Patent EP1572962.
AK313502 - Homo sapiens cDNA, FLJ94057, highly similar to Homo sapiens leucine-zipper-like transcriptional regulator, 1(LZTR1), mRNA.
JD293015 - Sequence 274039 from Patent EP1572962.
JD498005 - Sequence 479029 from Patent EP1572962.
JD152712 - Sequence 133736 from Patent EP1572962.
JD177383 - Sequence 158407 from Patent EP1572962.
JD304342 - Sequence 285366 from Patent EP1572962.
JD365663 - Sequence 346687 from Patent EP1572962.
EU176560 - Synthetic construct Homo sapiens clone IMAGE:100011377; FLH169593.01L; RZPDo839E0195D leucine-zipper-like transcription regulator 1 (LZTR1) gene, encodes complete protein.
EU176252 - Synthetic construct Homo sapiens clone IMAGE:100006366; FLH169597.01X; RZPDo839E0196D leucine-zipper-like transcription regulator 1 (LZTR1) gene, encodes complete protein.
KJ901866 - Synthetic construct Homo sapiens clone ccsbBroadEn_11260 LZTR1 gene, encodes complete protein.
BC128172 - Homo sapiens proline rich membrane anchor 1, mRNA (cDNA clone IMAGE:40113068), with apparent retained intron.
AL833698 - Homo sapiens mRNA; cDNA DKFZp667F119 (from clone DKFZp667F119).
JD072455 - Sequence 53479 from Patent EP1572962.
JD459298 - Sequence 440322 from Patent EP1572962.
JD396786 - Sequence 377810 from Patent EP1572962.
JD422788 - Sequence 403812 from Patent EP1572962.
JD220468 - Sequence 201492 from Patent EP1572962.
JD322574 - Sequence 303598 from Patent EP1572962.
JD382504 - Sequence 363528 from Patent EP1572962.
JD065298 - Sequence 46322 from Patent EP1572962.
U79243 - Human clone 23772 mRNA sequence.
JD443969 - Sequence 424993 from Patent EP1572962.
JD309607 - Sequence 290631 from Patent EP1572962.
JD525975 - Sequence 506999 from Patent EP1572962.
JD401390 - Sequence 382414 from Patent EP1572962.
JD135006 - Sequence 116030 from Patent EP1572962.
JD381062 - Sequence 362086 from Patent EP1572962.
JD538206 - Sequence 519230 from Patent EP1572962.
JD534473 - Sequence 515497 from Patent EP1572962.
JD315799 - Sequence 296823 from Patent EP1572962.
JD206234 - Sequence 187258 from Patent EP1572962.
JD192593 - Sequence 173617 from Patent EP1572962.
JD487152 - Sequence 468176 from Patent EP1572962.
JD191997 - Sequence 173021 from Patent EP1572962.
JD125284 - Sequence 106308 from Patent EP1572962.
JD381650 - Sequence 362674 from Patent EP1572962.
JD430872 - Sequence 411896 from Patent EP1572962.
JD240201 - Sequence 221225 from Patent EP1572962.
JD417978 - Sequence 399002 from Patent EP1572962.
JD119550 - Sequence 100574 from Patent EP1572962.
JD466996 - Sequence 448020 from Patent EP1572962.
JD219438 - Sequence 200462 from Patent EP1572962.
JD533277 - Sequence 514301 from Patent EP1572962.
JD544598 - Sequence 525622 from Patent EP1572962.
JD255135 - Sequence 236159 from Patent EP1572962.
JD402766 - Sequence 383790 from Patent EP1572962.
JD276726 - Sequence 257750 from Patent EP1572962.
JD203220 - Sequence 184244 from Patent EP1572962.
JD157055 - Sequence 138079 from Patent EP1572962.
JD465260 - Sequence 446284 from Patent EP1572962.
JD205227 - Sequence 186251 from Patent EP1572962.
JD074787 - Sequence 55811 from Patent EP1572962.
JD341495 - Sequence 322519 from Patent EP1572962.
JD309032 - Sequence 290056 from Patent EP1572962.
JD449117 - Sequence 430141 from Patent EP1572962.
JD276718 - Sequence 257742 from Patent EP1572962.
JD039402 - Sequence 20426 from Patent EP1572962.
JD221582 - Sequence 202606 from Patent EP1572962.
JD492484 - Sequence 473508 from Patent EP1572962.
JD248539 - Sequence 229563 from Patent EP1572962.
JD187400 - Sequence 168424 from Patent EP1572962.
JD108586 - Sequence 89610 from Patent EP1572962.
JD062465 - Sequence 43489 from Patent EP1572962.
JD320069 - Sequence 301093 from Patent EP1572962.
JD260596 - Sequence 241620 from Patent EP1572962.
JD268819 - Sequence 249843 from Patent EP1572962.
JD306523 - Sequence 287547 from Patent EP1572962.
JD429666 - Sequence 410690 from Patent EP1572962.
JD285680 - Sequence 266704 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000646124.1, LZTR1 , LZTR1_HUMAN, NM_006767, Q14776, Q20WK0, Q8N653, TCFL2, uc328mfr.1, uc328mfr.2
UCSC ID: ENST00000646124.2_5
RefSeq Accession: NM_006767.4
Protein: Q8N653 (aka LZTR1_HUMAN or LZTR_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene LZTR1:
noonan (Noonan Syndrome)
schwann (LZTR1- and SMARCB1-Related Schwannomatosis)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
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