ID:MGN2_HUMAN DESCRIPTION: RecName: Full=Protein mago nashi homolog 2; FUNCTION: Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway (By similarity). SUBUNIT: Interacts with RBM8A and is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2 and ALYREF/THOC4. Remains associated with the mRNA after its export to the cytoplasm and require translation of the mRNA for removal (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the mago nashi family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96A72
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK022720 - Homo sapiens cDNA FLJ12658 fis, clone NT2RM4002146, weakly similar to Homo sapiens MAGOH mRNA. JD092376 - Sequence 73400 from Patent EP1572962. JD552819 - Sequence 533843 from Patent EP1572962. JD308503 - Sequence 289527 from Patent EP1572962. JD355063 - Sequence 336087 from Patent EP1572962. JD449640 - Sequence 430664 from Patent EP1572962. JD403488 - Sequence 384512 from Patent EP1572962. JD188595 - Sequence 169619 from Patent EP1572962. JD386249 - Sequence 367273 from Patent EP1572962. JD549875 - Sequence 530899 from Patent EP1572962. JD507863 - Sequence 488887 from Patent EP1572962. JD095347 - Sequence 76371 from Patent EP1572962. JD511285 - Sequence 492309 from Patent EP1572962. JD247738 - Sequence 228762 from Patent EP1572962. JD360455 - Sequence 341479 from Patent EP1572962. JD172515 - Sequence 153539 from Patent EP1572962. JD563365 - Sequence 544389 from Patent EP1572962. JD181652 - Sequence 162676 from Patent EP1572962. JD309772 - Sequence 290796 from Patent EP1572962. JD507852 - Sequence 488876 from Patent EP1572962. AK001154 - Homo sapiens cDNA FLJ10292 fis, clone NT2RM1000257, highly similar to MAGO NASHI PROTEIN. BC000928 - Homo sapiens cDNA clone IMAGE:3447677, **** WARNING: chimeric clone ****. AK096106 - Homo sapiens cDNA FLJ38787 fis, clone LIVER2001835, moderately similar to MAGO NASHI PROTEIN. AF165518 - Homo sapiens MAGOH isoform (MAGOH) mRNA, complete cds. BC010905 - Homo sapiens mago-nashi homolog B (Drosophila), mRNA (cDNA clone MGC:13418 IMAGE:4283108), complete cds. JD501946 - Sequence 482970 from Patent EP1572962. KF051004 - Homo sapiens mago nashi protein mRNA, complete cds. AB528590 - Synthetic construct DNA, clone: pF1KB5823, Homo sapiens MAGOHB gene for mago-nashi homolog B, without stop codon, in Flexi system.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96A72 (Reactome details) participates in the following event(s):
R-HSA-156661 Formation of Exon Junction Complex R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-72185 mRNA polyadenylation R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-75096 Docking of the TAP:EJC Complex with the NPC R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-75098 mRNP complex dissociates from cytosolic face of NPC R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-72187 mRNA 3'-end processing R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-8953854 Metabolism of RNA R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-376176 Signaling by ROBO receptors R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-422475 Axon guidance R-HSA-73857 RNA Polymerase II Transcription R-HSA-1266738 Developmental Biology R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
