ID:MAGT1_HUMAN DESCRIPTION: RecName: Full=Magnesium transporter protein 1; Short=MagT1; AltName: Full=Implantation-associated protein; Short=IAP; Flags: Precursor; FUNCTION: May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involved in Mg(2+) transport in epithelial cells. SUBUNIT: Weakly associates with the oligosaccharyl transferase (OST) complex which contains at least RPN1/ribophorin I, RPN2/ribophorin II, OST48, DAD1, and either STT3A or STT3B (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable). TISSUE SPECIFICITY: Ubiquitous. Expressed at very low levels in brain, lung and kidney. INDUCTION: Up-regulated by low extracellular Mg(2+). DISEASE: Defects in MAGT1 are the cause of mental retardation X- linked type 95 (MRX95) [MIM:300716]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. DISEASE: Defects in MAGT1 are the cause of immunodeficiency X- linked with magnesium defect Epstein-Barr virus infection and neoplasia (XMEN) [MIM:300853]. XMEN is a disease characterized by CD4 lymphopenia, severe chronic viral infections, and defective T- lymphocyte activation. SIMILARITY: Belongs to the OST3/OST6 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H0U3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006486 protein glycosylation GO:0006487 protein N-linked glycosylation GO:0015693 magnesium ion transport GO:0018279 protein N-linked glycosylation via asparagine GO:0043312 neutrophil degranulation GO:0050890 cognition GO:0055085 transmembrane transport GO:1903830 magnesium ion transmembrane transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
