ID:MALT1_HUMAN DESCRIPTION: RecName: Full=Mucosa-associated lymphoid tissue lymphoma translocation protein 1; EC=3.4.22.-; AltName: Full=MALT lymphoma-associated translocation; AltName: Full=Paracaspase; FUNCTION: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. SUBUNIT: Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. INTERACTION: Q14790:CASP8; NbExp=8; IntAct=EBI-1047372, EBI-78060; SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. TISSUE SPECIFICITY: Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. DISEASE: Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. SIMILARITY: Belongs to the peptidase C14B family. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MALT1ID240.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UDY8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001923 B-1 B cell differentiation GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002726 positive regulation of T cell cytokine production GO:0006508 proteolysis GO:0006952 defense response GO:0007250 activation of NF-kappaB-inducing kinase activity GO:0009620 response to fungus GO:0016567 protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0032743 positive regulation of interleukin-2 production GO:0038095 Fc-epsilon receptor signaling pathway GO:0042098 T cell proliferation GO:0042113 B cell activation GO:0042981 regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0045087 innate immune response GO:0050852 T cell receptor signaling pathway GO:0050856 regulation of T cell receptor signaling pathway GO:0050870 positive regulation of T cell activation GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051168 nuclear export GO:0051259 protein oligomerization GO:2000321 positive regulation of T-helper 17 cell differentiation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
