ID:MANF_HUMAN DESCRIPTION: RecName: Full=Mesencephalic astrocyte-derived neurotrophic factor; AltName: Full=Arginine-rich protein; AltName: Full=Protein ARMET; Flags: Precursor; FUNCTION: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. SUBCELLULAR LOCATION: Secreted. INDUCTION: By endoplasmic reticulum stress. DOMAIN: The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. PTM: May contain sialic acid residues. SIMILARITY: Belongs to the ARMET family. CAUTION: Was originally (PubMed:8649854, PubMed:8971156 and PubMed:9174057) thought to be much longer and included an arginine-rich region thought to be the target of cancer-causing mutations. All these mutations are in what is now thought to be the 5'-UTR of the mRNA. CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator. SEQUENCE CAUTION: Sequence=AAB08753.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAI13589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAI13591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55145
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
