ID:MP2K2_HUMAN DESCRIPTION: RecName: Full=Dual specificity mitogen-activated protein kinase kinase 2; Short=MAP kinase kinase 2; Short=MAPKK 2; EC=2.7.12.2; AltName: Full=ERK activator kinase 2; AltName: Full=MAPK/ERK kinase 2; Short=MEK 2; FUNCTION: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Interacts with MORG1 (By similarity). Interacts with SGK1. INTERACTION: P10398:ARAF; NbExp=4; IntAct=EBI-1056930, EBI-365961; PTM: MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity). PTM: Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway. DISEASE: Defects in MAP2K2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. SIMILARITY: Contains 1 protein kinase domain. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MAP2K2";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P36507
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0000187 activation of MAPK activity GO:0006468 protein phosphorylation GO:0007346 regulation of mitotic cell cycle GO:0010629 negative regulation of gene expression GO:0016310 phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0032872 regulation of stress-activated MAPK cascade GO:0036289 peptidyl-serine autophosphorylation GO:0042981 regulation of apoptotic process GO:0045893 positive regulation of transcription, DNA-templated GO:0070371 ERK1 and ERK2 cascade GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0090170 regulation of Golgi inheritance GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:2000641 regulation of early endosome to late endosome transport
BioCarta from NCI Cancer Genome Anatomy Project h_erkPathway - Erk1/Erk2 Mapk Signaling pathway h_mapkPathway - MAPKinase Signaling Pathway h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling h_hcmvPathway - Human Cytomegalovirus and Map Kinase Pathways h_anthraxPathway - Anthrax Toxin Mechanism of Action h_integrinPathway - Integrin Signaling Pathway h_cdk5Pathway - Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway h_pyk2Pathway - Links between Pyk2 and Map Kinases h_bArrestin-srcPathway - Roles of ¿-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling h_malPathway - Role of MAL in Rho-Mediated Activation of SRF h_barr-mapkPathway - Role of ¿-arrestins in the activation and targeting of MAP kinases h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway h_metPathway - Signaling of Hepatocyte Growth Factor Receptor h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells
Reactome (by CSHL, EBI, and GO)
Protein P36507 (Reactome details) participates in the following event(s):
R-HSA-5211356 Anthrax LF cleaves target cell MAP2K2 (MEK2) R-HSA-109858 MAP2K2 binds MAPK1 R-HSA-109864 Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 R-HSA-109862 MAP2K2 phosphorylates MAPK1 R-HSA-5674496 Activated MAPKs phosphorylate MAP2K1 R-HSA-5672972 MAP2Ks and MAPKs bind to the activated RAF complex R-HSA-5674132 WDR83:LAMTOR2:LAMTOR3 binds MAPK components R-HSA-6802912 High kinase activity BRAF mutants bind MAP2Ks and MAPKs R-HSA-6802914 RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs R-HSA-6802925 Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs R-HSA-6802942 RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs R-HSA-5674366 IL17RD binds p-2S MAP2Ks and MAPKs R-HSA-5672980 Dissociation of RAS:RAF complex R-HSA-6802932 Dissociation of BRAF/RAF fusion complex R-HSA-6803227 Dissociation of high activity BRAF complexes R-HSA-6803230 Dissociation of moderate activity BRAF complexes R-HSA-6803233 Dissociation of oncogenic RAS:RAF complex R-HSA-6803234 Dissociation of paradoxically activated RAS:BRAF complexes R-HSA-5672978 RAF phosphorylates MAP2K dimer R-HSA-6802943 RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks R-HSA-6802919 RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks R-HSA-6802911 High kinase activity BRAF complexes phosphorylate MAP2Ks R-HSA-6802926 Mutant RAS:p-RAF complexes phosphorylate MAP2Ks R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks R-HSA-5672973 MAP2Ks phosphorylate MAPKs R-HSA-5674373 MAP2Ks phosphorylate MAPK at the Golgi membrane R-HSA-6802918 Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants R-HSA-6802921 Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants R-HSA-6802910 Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants R-HSA-6802922 Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers R-HSA-5672969 Phosphorylation of RAF R-HSA-6802916 RAF is phosphorylated downstream of moderate kinase activity BRAF mutants R-HSA-6802924 RAF is phosphorylated downstream of oncogenic RAS R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated R-HSA-6802941 RAF is paradoxically phosphorylated downstream of kinase-inactive RAF R-HSA-5210891 Uptake and function of anthrax toxins R-HSA-112411 MAPK1 (ERK2) activation R-HSA-5339562 Uptake and actions of bacterial toxins R-HSA-445144 Signal transduction by L1 R-HSA-112409 RAF-independent MAPK1/3 activation R-HSA-5674499 Negative feedback regulation of MAPK pathway R-HSA-5674135 MAP2K and MAPK activation R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-5663205 Infectious disease R-HSA-373760 L1CAM interactions R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-5675221 Negative regulation of MAPK pathway R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6802957 Oncogenic MAPK signaling R-HSA-1643685 Disease R-HSA-422475 Axon guidance R-HSA-5683057 MAPK family signaling cascades R-HSA-5663202 Diseases of signal transduction R-HSA-1266738 Developmental Biology R-HSA-162582 Signal Transduction R-HSA-5673000 RAF activation