ID:M3K10_HUMAN DESCRIPTION: RecName: Full=Mitogen-activated protein kinase kinase kinase 10; EC=2.7.11.25; AltName: Full=Mixed lineage kinase 2; AltName: Full=Protein kinase MST; FUNCTION: Activates the JUN N-terminal pathway (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium (By similarity). ENZYME REGULATION: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation (By similarity). SUBUNIT: Homodimer (By similarity). TISSUE SPECIFICITY: Expressed in brain and skeletal muscle. PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 1 SH3 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q02779
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0003714 transcription corepressor activity GO:0004672 protein kinase activity GO:0004674 protein serine/threonine kinase activity GO:0004706 JUN kinase kinase kinase activity GO:0004709 MAP kinase kinase kinase activity GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0042803 protein homodimerization activity GO:0043425 bHLH transcription factor binding
Biological Process: GO:0000186 activation of MAPKK activity GO:0006468 protein phosphorylation GO:0006915 apoptotic process GO:0007165 signal transduction GO:0007224 smoothened signaling pathway GO:0007254 JNK cascade GO:0007256 activation of JNKK activity GO:0007257 activation of JUN kinase activity GO:0008219 cell death GO:0016310 phosphorylation GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0043065 positive regulation of apoptotic process GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043507 positive regulation of JUN kinase activity GO:0045892 negative regulation of transcription, DNA-templated GO:0046330 positive regulation of JNK cascade GO:0046777 protein autophosphorylation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
