ID:M3K2_HUMAN DESCRIPTION: RecName: Full=Mitogen-activated protein kinase kinase kinase 2; EC=2.7.11.25; AltName: Full=MAPK/ERK kinase kinase 2; Short=MEK kinase 2; Short=MEKK 2; FUNCTION: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by phosphorylation on Thr-524 (By similarity). SUBUNIT: Interacts with PKN2; the interaction activates PKN2 kinase activity in a MAP3K2-independent kinase activity (By similarity). Self-associates. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. Interacts with XIAP/BIRC4. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus. PTM: Autophosphorylated (By similarity). PTM: Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. SIMILARITY: Contains 1 OPR domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAC11348.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y2U5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000186 activation of MAPKK activity GO:0000187 activation of MAPK activity GO:0006468 protein phosphorylation GO:0007257 activation of JUN kinase activity GO:0007346 regulation of mitotic cell cycle GO:0016310 phosphorylation GO:0042981 regulation of apoptotic process GO:0045893 positive regulation of transcription, DNA-templated GO:0071260 cellular response to mechanical stimulus
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
