ID:M3K3_HUMAN DESCRIPTION: RecName: Full=Mitogen-activated protein kinase kinase kinase 3; EC=2.7.11.25; AltName: Full=MAPK/ERK kinase kinase 3; Short=MEK kinase 3; Short=MEKK 3; FUNCTION: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by phosphorylation on Thr-530 (By similarity). SUBUNIT: Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex with MAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9. INTERACTION: Q6Q0C0:TRAF7; NbExp=3; IntAct=EBI-307281, EBI-307556; PTM: Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. SIMILARITY: Contains 1 OPR domain. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99759
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0000186 activation of MAPKK activity GO:0001568 blood vessel development GO:0006468 protein phosphorylation GO:0007346 regulation of mitotic cell cycle GO:0016310 phosphorylation GO:0031098 stress-activated protein kinase signaling cascade GO:0032147 activation of protein kinase activity GO:0035556 intracellular signal transduction GO:0042981 regulation of apoptotic process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0046777 protein autophosphorylation GO:0070498 interleukin-1-mediated signaling pathway GO:0071864 positive regulation of cell proliferation in bone marrow GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis GO:1900745 positive regulation of p38MAPK cascade GO:2000773 negative regulation of cellular senescence
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
