ID:M4K1_HUMAN DESCRIPTION: RecName: Full=Mitogen-activated protein kinase kinase kinase kinase 1; EC=2.7.11.1; AltName: Full=Hematopoietic progenitor kinase; AltName: Full=MAPK/ERK kinase kinase kinase 1; Short=MEK kinase kinase 1; Short=MEKKK 1; FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. SUBUNIT: Interacts with MAP3K1. INTERACTION: P00519:ABL1; NbExp=2; IntAct=EBI-881, EBI-375543; P46108:CRK; NbExp=3; IntAct=EBI-881, EBI-886; P46109:CRKL; NbExp=5; IntAct=EBI-881, EBI-910; P06241:FYN; NbExp=2; IntAct=EBI-881, EBI-515315; P62993:GRB2; NbExp=2; IntAct=EBI-881, EBI-401755; P16333:NCK1; NbExp=2; IntAct=EBI-881, EBI-389883; P27986:PIK3R1; NbExp=2; IntAct=EBI-881, EBI-79464; P19174:PLCG1; NbExp=6; IntAct=EBI-881, EBI-79387; TISSUE SPECIFICITY: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. SIMILARITY: Contains 1 CNH domain. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF00780 - CNH domain PF07714 - Protein tyrosine and serine/threonine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q92918
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000185 activation of MAPKKK activity GO:0006468 protein phosphorylation GO:0007257 activation of JUN kinase activity GO:0007346 regulation of mitotic cell cycle GO:0008283 cell proliferation GO:0016310 phosphorylation GO:0018105 peptidyl-serine phosphorylation GO:0035556 intracellular signal transduction GO:0042981 regulation of apoptotic process GO:0046777 protein autophosphorylation GO:1904628 cellular response to phorbol 13-acetate 12-myristate
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
