ID:M4K3_HUMAN DESCRIPTION: RecName: Full=Mitogen-activated protein kinase kinase kinase kinase 3; EC=2.7.11.1; AltName: Full=Germinal center kinase-related protein kinase; Short=GLK; AltName: Full=MAPK/ERK kinase kinase kinase 3; Short=MEK kinase kinase 3; Short=MEKKK 3; FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. SUBUNIT: Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation (By similarity). INTERACTION: P62993:GRB2; NbExp=2; IntAct=EBI-1758170, EBI-401755; Q13094:LCP2; NbExp=5; IntAct=EBI-1758170, EBI-346946; Q04759:PRKCQ; NbExp=4; IntAct=EBI-1758170, EBI-374762; Q02111:Prkcq (xeno); NbExp=4; IntAct=EBI-1758170, EBI-2639157; TISSUE SPECIFICITY: Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. SIMILARITY: Contains 1 CNH domain. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF00780 - CNH domain PF07714 - Protein tyrosine and serine/threonine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q8IVH8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.