Human Gene MAP4K5 (ENST00000682126.1_4) from GENCODE V47lift37
  Description: mitogen-activated protein kinase kinase kinase kinase 5, transcript variant 1 (from RefSeq NM_006575.6)
Gencode Transcript: ENST00000682126.1_4
Gencode Gene: ENSG00000012983.12_11
Transcript (Including UTRs)
   Position: hg19 chr14:50,885,239-50,999,287 Size: 114,049 Total Exon Count: 33 Strand: -
Coding Region
   Position: hg19 chr14:50,886,737-50,998,767 Size: 112,031 Coding Exon Count: 32 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:50,885,239-50,999,287)mRNA (may differ from genome)Protein (846 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MAP4K5
Diseases sorted by gene-association score: dysgraphia (16), writing disorder (11)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -120.30231-0.521 Picture PostScript Text
3' UTR -321.501498-0.215 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  LF209551 - JP 2014500723-A/17054: Polycomb-Associated Non-Coding RNAs.
BC036013 - Homo sapiens mitogen-activated protein kinase kinase kinase kinase 5, mRNA (cDNA clone MGC:32909 IMAGE:5272190), complete cds.
U77129 - Human SPS1/STE20 homolog KHS1 mRNA, complete cds.
AK313612 - Homo sapiens cDNA, FLJ94181, highly similar to Homo sapiens mitogen-activated protein kinase kinase kinase kinase5 (MAP4K5), mRNA.
KJ905413 - Synthetic construct Homo sapiens clone ccsbBroadEn_14987 MAP4K5 gene, encodes complete protein.
DQ894186 - Synthetic construct Homo sapiens clone IMAGE:100008646; FLH168470.01L; RZPDo839H0391D mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) gene, encodes complete protein.
AB528468 - Synthetic construct DNA, clone: pF1KB8476, Homo sapiens MAP4K5 gene for mitogen-activated protein kinase kinase kinase kinase 5, without stop codon, in Flexi system.
BC013159 - Homo sapiens mitogen-activated protein kinase kinase kinase kinase 5, mRNA (cDNA clone IMAGE:4345282), with apparent retained intron.
MA445128 - JP 2018138019-A/17054: Polycomb-Associated Non-Coding RNAs.
AK124738 - Homo sapiens cDNA FLJ42748 fis, clone BRAWH3000329, highly similar to Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1).
LF329423 - JP 2014500723-A/136926: Polycomb-Associated Non-Coding RNAs.
LF329424 - JP 2014500723-A/136927: Polycomb-Associated Non-Coding RNAs.
JD313333 - Sequence 294357 from Patent EP1572962.
JD357490 - Sequence 338514 from Patent EP1572962.
JD349551 - Sequence 330575 from Patent EP1572962.
LF329428 - JP 2014500723-A/136931: Polycomb-Associated Non-Coding RNAs.
LF329430 - JP 2014500723-A/136933: Polycomb-Associated Non-Coding RNAs.
LF329432 - JP 2014500723-A/136935: Polycomb-Associated Non-Coding RNAs.
LF329434 - JP 2014500723-A/136937: Polycomb-Associated Non-Coding RNAs.
Z25426 - H.sapiens protein-serine/threonine kinase gene, complete CDS.
MA565000 - JP 2018138019-A/136926: Polycomb-Associated Non-Coding RNAs.
MA565001 - JP 2018138019-A/136927: Polycomb-Associated Non-Coding RNAs.
MA565005 - JP 2018138019-A/136931: Polycomb-Associated Non-Coding RNAs.
MA565007 - JP 2018138019-A/136933: Polycomb-Associated Non-Coding RNAs.
MA565009 - JP 2018138019-A/136935: Polycomb-Associated Non-Coding RNAs.
MA565011 - JP 2018138019-A/136937: Polycomb-Associated Non-Coding RNAs.
JD140042 - Sequence 121066 from Patent EP1572962.
JD407101 - Sequence 388125 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_mapkPathway - MAPKinase Signaling Pathway
h_41bbPathway - The 4-1BB-dependent immune response

-  Other Names for This Gene
  Alternate Gene Symbols: A0A804HIS2, A0A804HIS2_HUMAN, MAP4K5 , NM_006575, uc330jlo.1, uc330jlo.2
UCSC ID: ENST00000682126.1_4
RefSeq Accession: NM_006575.6

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.