ID:Q1HBJ4_HUMAN DESCRIPTION: SubName: Full=Mitogen-activated protein kinase 1; SubName: Full=Mitogen-activated protein kinase 1, isoform CRA_a; CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine and serine/threonine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q1HBJ4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_ecmPathway - Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia h_mPRPathway - How Progesterone Initiates the Oocyte Maturation h_stat3Pathway - Stat3 Signaling Pathway h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway h_erkPathway - Erk1/Erk2 Mapk Signaling pathway h_metPathway - Signaling of Hepatocyte Growth Factor Receptor h_pyk2Pathway - Links between Pyk2 and Map Kinases h_tffPathway - Trefoil Factors Initiate Mucosal Healing h_erk5Pathway - Role of Erk5 in Neuronal Survival h_ghPathway - Growth Hormone Signaling Pathway h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) h_CCR3Pathway - CCR3 signaling in Eosinophils h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition h_bArrestin-srcPathway - Roles of ¿-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling h_cdk5Pathway - Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway h_ceramidePathway - Ceramide Signaling Pathway h_edg1Pathway - Phospholipids as signalling intermediaries h_integrinPathway - Integrin Signaling Pathway h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_sam68Pathway - Regulation of Splicing through Sam68 h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation h_cdMacPathway - Cadmium induces DNA synthesis and proliferation in macrophages h_malPathway - Role of MAL in Rho-Mediated Activation of SRF h_badPathway - Regulation of BAD phosphorylation h_crebPathway - Transcription factor CREB and its extracellular signals h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase h_mapkPathway - MAPKinase Signaling Pathway h_spryPathway - Sprouty regulation of tyrosine kinase signals h_cxcr4Pathway - CXCR4 Signaling Pathway h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation h_keratinocytePathway - Keratinocyte Differentiation h_sppaPathway - Aspirin Blocks Signaling Pathway Involved in Platelet Activation h_arenrf2Pathway - Oxidative Stress Induced Gene Expression Via Nrf2 h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells h_pelp1Pathway - Pelp1 Modulation of Estrogen Receptor Activity h_agrPathway - Agrin in Postsynaptic Differentiation h_barr-mapkPathway - Role of ¿-arrestins in the activation and targeting of MAP kinases h_hcmvPathway - Human Cytomegalovirus and Map Kinase Pathways h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis
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Common Gene Haplotype Alleles 
