Human Gene MAPK1 (ENST00000215832.11_7) from GENCODE V47lift37
  Description: mitogen-activated protein kinase 1, transcript variant 1 (from RefSeq NM_002745.5)
Gencode Transcript: ENST00000215832.11_7
Gencode Gene: ENSG00000100030.15_8
Transcript (Including UTRs)
   Position: hg19 chr22:22,113,946-22,221,935 Size: 107,990 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr22:22,123,493-22,221,730 Size: 98,238 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:22,113,946-22,221,935)mRNA (may differ from genome)Protein (360 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q1HBJ4_HUMAN
DESCRIPTION: SubName: Full=Mitogen-activated protein kinase 1; SubName: Full=Mitogen-activated protein kinase 1, isoform CRA_a;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MAPK1
Diseases sorted by gene-association score: chromosome 22q11.2 deletion syndrome, distal* (29), pertussis (14), retrograde amnesia (13), pancreatic cancer (11), differentiating neuroblastoma (10), small intestine neuroendocrine neoplasm (8), lung cancer (8), cervical mucinous adenocarcinoma (7), ovarian epithelial cancer (7), myasthenic syndrome, congenital, 7, presynaptic (7), chromosome 6pter-p24 deletion syndrome (7), acromesomelic dysplasia, maroteaux type (6), acute vascular insufficiency of intestine (6), rothmund-thomson syndrome (6), cardiofaciocutaneous syndrome (6), newcastle disease (5), hepatitis (5), colorectal cancer (5), louse-borne relapsing fever (5), gastric tubular adenocarcinoma (4), fructose intolerance, hereditary (4), acromesomelic dysplasia (4), endometrial cancer (4), noonan syndrome 1 (4), primary syphilis (4), glioblastoma multiforme (4), prostate cancer (3), fibrosarcoma (3), alzheimer disease (3), melanoma (3), hepatitis c virus (3), breast cancer (3), renal cell carcinoma (2), pheochromocytoma (2), insulin-like growth factor i (2), lung cancer susceptibility 3 (2), osteosarcoma, somatic (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.30 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 711.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -109.90205-0.536 Picture PostScript Text
3' UTR -1311.604593-0.286 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR003527 - MAP_kinase_CS
IPR008349 - MAPK_ERK1/2
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q1HBJ4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0001784 phosphotyrosine binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019901 protein kinase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0042802 identical protein binding

Biological Process:
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007165 signal transduction
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0009636 response to toxic substance
GO:0009887 animal organ morphogenesis
GO:0014032 neural crest cell development
GO:0015966 diadenosine tetraphosphate biosynthetic process
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019233 sensory perception of pain
GO:0019858 cytosine metabolic process
GO:0030278 regulation of ossification
GO:0030335 positive regulation of cell migration
GO:0030641 regulation of cellular pH
GO:0030878 thyroid gland development
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0033598 mammary gland epithelial cell proliferation
GO:0035094 response to nicotine
GO:0035556 intracellular signal transduction
GO:0042473 outer ear morphogenesis
GO:0043330 response to exogenous dsRNA
GO:0043627 response to estrogen
GO:0045596 negative regulation of cell differentiation
GO:0045727 positive regulation of translation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048538 thymus development
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0060020 Bergmann glial cell differentiation
GO:0060291 long-term synaptic potentiation
GO:0060324 face development
GO:0060425 lung morphogenesis
GO:0060440 trachea formation
GO:0060716 labyrinthine layer blood vessel development
GO:0061308 cardiac neural crest cell development involved in heart development
GO:0070371 ERK1 and ERK2 cascade
GO:0071310 cellular response to organic substance
GO:0071356 cellular response to tumor necrosis factor
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0030424 axon
GO:0031143 pseudopodium
GO:0032839 dendrite cytoplasm
GO:0032991 macromolecular complex
GO:0043204 perikaryon


-  Descriptions from all associated GenBank mRNAs
  EF565108 - Homo sapiens chromosome 22 isolate HA_003333 mRNA sequence.
MA241956 - JP 2017061491-A/17: Composition and method for inner ear sensor hair cell regeneration or replacement.
BC099905 - Homo sapiens mitogen-activated protein kinase 1, mRNA (cDNA clone MGC:104558 IMAGE:5264558), complete cds.
AK090869 - Homo sapiens cDNA FLJ33550 fis, clone BRAMY2009034, highly similar to MITOGEN-ACTIVATED PROTEIN KINASE 1 (EC 2.7.1.-).
Z11695 - H.sapiens 40 kDa protein kinase related to rat ERK2.
Z11694 - H.sapiens 41kDa protein kinase related to rat ERK2.
AK307615 - Homo sapiens cDNA, FLJ97563.
AK295188 - Homo sapiens cDNA FLJ58314 complete cds, highly similar to Mitogen-activated protein kinase 1 (EC 2.7.11.24).
M84489 - Human extracellular signal-regulated kinase 2 mRNA, complete cds.
BC017832 - Homo sapiens mitogen-activated protein kinase 1, mRNA (cDNA clone MGC:22485 IMAGE:4685557), complete cds.
EU831429 - Synthetic construct Homo sapiens clone HAIB:100066458; DKFZo008C0417 mitogen-activated protein kinase 1 protein (MAPK1) gene, encodes complete protein.
DQ399292 - Homo sapiens extracellular signal-regulated kinase-2 splice variant mRNA, complete cds, alternatively spliced.
EU176323 - Synthetic construct Homo sapiens clone IMAGE:100006422; FLH182003.01X; RZPDo839F06251D mitogen-activated protein kinase 1 (MAPK1) gene, encodes complete protein.
EU831522 - Synthetic construct Homo sapiens clone HAIB:100066551; DKFZo004C0418 mitogen-activated protein kinase 1 protein (MAPK1) gene, encodes complete protein.
AB384931 - Synthetic construct DNA, clone: pF1KB4351, Homo sapiens MAPK1 gene for mitogen-activated protein kinase 1, complete cds, without stop codon, in Flexi system.
LQ973139 - Sequence 17 from Patent EP2576781.
AL157438 - Homo sapiens mRNA; cDNA DKFZp434A115 (from clone DKFZp434A115).
JD067340 - Sequence 48364 from Patent EP1572962.
JD061023 - Sequence 42047 from Patent EP1572962.
JD042143 - Sequence 23167 from Patent EP1572962.
AK055080 - Homo sapiens cDNA FLJ30518 fis, clone BRAWH2000839.
AK057143 - Homo sapiens cDNA FLJ32581 fis, clone SPLEN2000304.
JD172124 - Sequence 153148 from Patent EP1572962.
JD450393 - Sequence 431417 from Patent EP1572962.
JD375559 - Sequence 356583 from Patent EP1572962.
JD240924 - Sequence 221948 from Patent EP1572962.
JD244246 - Sequence 225270 from Patent EP1572962.
JD089190 - Sequence 70214 from Patent EP1572962.
JD428741 - Sequence 409765 from Patent EP1572962.
JD566802 - Sequence 547826 from Patent EP1572962.
JD358302 - Sequence 339326 from Patent EP1572962.
JD154065 - Sequence 135089 from Patent EP1572962.
JD265531 - Sequence 246555 from Patent EP1572962.
JD565434 - Sequence 546458 from Patent EP1572962.
JD527665 - Sequence 508689 from Patent EP1572962.
JD221530 - Sequence 202554 from Patent EP1572962.
JD560576 - Sequence 541600 from Patent EP1572962.
JD183205 - Sequence 164229 from Patent EP1572962.
JD199825 - Sequence 180849 from Patent EP1572962.
JD323737 - Sequence 304761 from Patent EP1572962.
JD254003 - Sequence 235027 from Patent EP1572962.
JD109237 - Sequence 90261 from Patent EP1572962.
JD332824 - Sequence 313848 from Patent EP1572962.
JD163020 - Sequence 144044 from Patent EP1572962.
JD525180 - Sequence 506204 from Patent EP1572962.
JD152148 - Sequence 133172 from Patent EP1572962.
JD543891 - Sequence 524915 from Patent EP1572962.
JD363198 - Sequence 344222 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY66-14 - MAP kinase cascade

BioCarta from NCI Cancer Genome Anatomy Project
h_ecmPathway - Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
h_mPRPathway - How Progesterone Initiates the Oocyte Maturation
h_stat3Pathway - Stat3 Signaling Pathway
h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_erkPathway - Erk1/Erk2 Mapk Signaling pathway
h_metPathway - Signaling of Hepatocyte Growth Factor Receptor
h_pyk2Pathway - Links between Pyk2 and Map Kinases
h_tffPathway - Trefoil Factors Initiate Mucosal Healing
h_erk5Pathway - Role of Erk5 in Neuronal Survival
h_ghPathway - Growth Hormone Signaling Pathway
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
h_CCR3Pathway - CCR3 signaling in Eosinophils
h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition
h_bArrestin-srcPathway - Roles of ¿-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling
h_cdk5Pathway - Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway
h_ceramidePathway - Ceramide Signaling Pathway
h_edg1Pathway - Phospholipids as signalling intermediaries
h_integrinPathway - Integrin Signaling Pathway
h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
h_sam68Pathway - Regulation of Splicing through Sam68
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation
h_cdMacPathway - Cadmium induces DNA synthesis and proliferation in macrophages
h_malPathway - Role of MAL in Rho-Mediated Activation of SRF
h_badPathway - Regulation of BAD phosphorylation
h_crebPathway - Transcription factor CREB and its extracellular signals
h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_mapkPathway - MAPKinase Signaling Pathway
h_spryPathway - Sprouty regulation of tyrosine kinase signals
h_cxcr4Pathway - CXCR4 Signaling Pathway
h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells
h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
h_keratinocytePathway - Keratinocyte Differentiation
h_sppaPathway - Aspirin Blocks Signaling Pathway Involved in Platelet Activation
h_arenrf2Pathway - Oxidative Stress Induced Gene Expression Via Nrf2
h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
h_pelp1Pathway - Pelp1 Modulation of Estrogen Receptor Activity
h_agrPathway - Agrin in Postsynaptic Differentiation
h_barr-mapkPathway - Role of ¿-arrestins in the activation and targeting of MAP kinases
h_hcmvPathway - Human Cytomegalovirus and Map Kinase Pathways
h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000215832.1, ENST00000215832.10, ENST00000215832.2, ENST00000215832.3, ENST00000215832.4, ENST00000215832.5, ENST00000215832.6, ENST00000215832.7, ENST00000215832.8, ENST00000215832.9, hCG_32557 , MAPK1 , NM_002745, Q1HBJ4, Q1HBJ4_HUMAN, uc317cmy.1, uc317cmy.2
UCSC ID: ENST00000215832.11_7
RefSeq Accession: NM_002745.5
Protein: Q1HBJ4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.