ID:MAST2_HUMAN DESCRIPTION: RecName: Full=Microtubule-associated serine/threonine-protein kinase 2; EC=2.7.11.1; FUNCTION: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium (By similarity). SUBUNIT: Interacts with CDHR2. INTERACTION: Q9BYE9:CDHR2; NbExp=4; IntAct=EBI-493777, EBI-493793; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Note=Recruited to the sub-membranous area on interaction with CDHR2. TISSUE SPECIFICITY: Abundant in the testis. PTM: Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. SIMILARITY: Contains 1 AGC-kinase C-terminal domain. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAH15816.2; Type=Erroneous initiation; Sequence=AAH15816.2; Type=Frameshift; Positions=1114, 1387; Sequence=BAB40778.1; Type=Frameshift; Positions=1688; Sequence=CAH73245.1; Type=Erroneous gene model prediction; Sequence=CAI16563.1; Type=Erroneous gene model prediction; Sequence=CAI21706.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6P0Q8
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
