ID:METK1_HUMAN DESCRIPTION: RecName: Full=S-adenosylmethionine synthase isoform type-1; Short=AdoMet synthase 1; EC=2.5.1.6; AltName: Full=Methionine adenosyltransferase 1; Short=MAT 1; AltName: Full=Methionine adenosyltransferase I/III; Short=MAT-I/III; FUNCTION: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. CATALYTIC ACTIVITY: ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine. COFACTOR: Binds 2 divalent ions per subunit. Magnesium or cobalt (By similarity). COFACTOR: Binds 1 potassium ion per subunit (By similarity). PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. SUBUNIT: Homotetramer (MAT-I) or homodimer (MAT-III). TISSUE SPECIFICITY: Expressed in liver. PTM: S-nitrosylation of Cys-120 inactivates the enzyme (By similarity). DISEASE: Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD) [MIM:250850]; also called MAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity. SIMILARITY: Belongs to the AdoMet synthase family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MAT1A";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q00266
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000096 sulfur amino acid metabolic process GO:0001887 selenium compound metabolic process GO:0006556 S-adenosylmethionine biosynthetic process GO:0006730 one-carbon metabolic process GO:0009087 methionine catabolic process GO:0032259 methylation GO:0051289 protein homotetramerization
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
