ID:MAVS_HUMAN DESCRIPTION: RecName: Full=Mitochondrial antiviral-signaling protein; Short=MAVS; AltName: Full=CARD adapter inducing interferon beta; Short=Cardif; AltName: Full=Interferon beta promoter stimulator protein 1; Short=IPS-1; AltName: Full=Putative NF-kappa-B-activating protein 031N; AltName: Full=Virus-induced-signaling adapter; Short=VISA; FUNCTION: Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. SUBUNIT: Interacts with DDX58/RIG-I, IFIH1/MDA5, TRAF2 and TRAF6. May interact with IRF3, FADD, RIPK1, CHUK and IKBKB. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is cleaved by HHAV protein 3ABC. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain. Interacts with PSMA7. Interacts with TRAFD1 (By similarity). Interacts (via C-terminus) with PCBP2 in a complex containing MAVS/IPS1, PCBP2 and ITCH. Interacts with CYLD. Interacts with SRC. Interacts with DHX58/LGP2 and IKBKE. Interacts with TMEM173/MITA. Interacts with IFIT3 (via N-terminus). Interacts with TBK1 only in the presence of IFIT3. INTERACTION: P46379:BAG6; NbExp=2; IntAct=EBI-995373, EBI-347552; Q13137:CALCOCO2; NbExp=3; IntAct=EBI-995373, EBI-739580; O00571:DDX3X; NbExp=4; IntAct=EBI-995373, EBI-353779; O95786:DDX58; NbExp=7; IntAct=EBI-995373, EBI-995350; Q14164:IKBKE; NbExp=2; IntAct=EBI-995373, EBI-307369; Q13568:IRF5; NbExp=2; IntAct=EBI-995373, EBI-3931258; Q9Y6K5:OAS3; NbExp=2; IntAct=EBI-995373, EBI-6115729; O43353:RIPK2; NbExp=3; IntAct=EBI-995373, EBI-358522; P42224:STAT1; NbExp=3; IntAct=EBI-995373, EBI-1057697; Q14139:UBE4A; NbExp=2; IntAct=EBI-995373, EBI-1048119; Q69027:X (xeno); NbExp=2; IntAct=EBI-995373, EBI-3650820; SUBCELLULAR LOCATION: Mitochondrion outer membrane. Mitochondrion. Peroxisome. TISSUE SPECIFICITY: Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. DOMAIN: Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58/RIG-I and IFIH1/MDA5. DOMAIN: The transmembrane domain and residues 300-444 are essential for its interaction with DHX58/LGP2. PTM: Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS/IPS1 proteasomal degradation. MISCELLANEOUS: Cleavage by HCV protease complex leads to inactivation. SIMILARITY: Contains 1 CARD domain. SEQUENCE CAUTION: Sequence=BAA86585.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB14684.1; Type=Frameshift; Positions=333;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z434
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001934 positive regulation of protein phosphorylation GO:0002218 activation of innate immune response GO:0002230 positive regulation of defense response to virus by host GO:0002376 immune system process GO:0007165 signal transduction GO:0016032 viral process GO:0032480 negative regulation of type I interferon production GO:0032727 positive regulation of interferon-alpha production GO:0032728 positive regulation of interferon-beta production GO:0032757 positive regulation of interleukin-8 production GO:0032760 positive regulation of tumor necrosis factor production GO:0033160 positive regulation of protein import into nucleus, translocation GO:0035549 positive regulation of interferon-beta secretion GO:0042742 defense response to bacterium GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0045071 negative regulation of viral genome replication GO:0045087 innate immune response GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051607 defense response to virus GO:0060340 positive regulation of type I interferon-mediated signaling pathway GO:0060760 positive regulation of response to cytokine stimulus GO:0071360 cellular response to exogenous dsRNA GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production GO:0071660 positive regulation of IP-10 production GO:1900063 regulation of peroxisome organization GO:1902741 positive regulation of interferon-alpha secretion GO:1904469 positive regulation of tumor necrosis factor secretion GO:2000778 positive regulation of interleukin-6 secretion
AK296897 - Homo sapiens cDNA FLJ58074 complete cds, highly similar to Mitochondrial antiviral signaling protein. AB097003 - Homo sapiens mRNA for putative NFkB activating protein, complete cds, clone: 031N. AK123956 - Homo sapiens cDNA FLJ41962 fis, clone PUAEN2005588. AK291785 - Homo sapiens cDNA FLJ76894 complete cds. BX649084 - Homo sapiens mRNA; cDNA DKFZp779L0861 (from clone DKFZp779L0861). AK023799 - Homo sapiens cDNA FLJ13737 fis, clone PLACE3000157. AX775775 - Sequence 45 from Patent WO03048202. JD191328 - Sequence 172352 from Patent EP1572962. JD408544 - Sequence 389568 from Patent EP1572962. BC044952 - Homo sapiens virus-induced signaling adapter, mRNA (cDNA clone MGC:50830 IMAGE:5751684), complete cds. AK130992 - Homo sapiens cDNA FLJ27482 fis, clone PCD04339. AB232371 - Homo sapiens Ips-1 mRNA, complete cds. AB033097 - Homo sapiens KIAA1271 mRNA for KIAA1271 protein. JD147806 - Sequence 128830 from Patent EP1572962. CU692246 - Synthetic construct Homo sapiens gateway clone IMAGE:100021498 5' read VISA mRNA. AB463122 - Synthetic construct DNA, clone: pF1KA1271, Homo sapiens MAVS gene for Mitochondrial antiviral-signaling protein, without stop codon, in Flexi system. EU832500 - Synthetic construct Homo sapiens clone HAIB:100067529; DKFZo008F0729 virus-induced signaling adapter protein (VISA) gene, encodes complete protein. EU832581 - Synthetic construct Homo sapiens clone HAIB:100067610; DKFZo004F0730 virus-induced signaling adapter protein (VISA) gene, encodes complete protein. DQ167126 - Homo sapiens virus-induced signaling adapter (VISA) mRNA, complete cds. DQ174270 - Homo sapiens mitochondrial anti-viral signaling protein (MAVS) mRNA, complete cds; nuclear gene for mitochondrial product. DQ181928 - Homo sapiens CARDIF mRNA, complete cds. EF467323 - Homo sapiens virus-induced signaling adaptor variant 1a (VISA) mRNA, complete cds, alternatively spliced. EF467324 - Homo sapiens virus-induced signaling adapter variant 1b (VISA) mRNA, complete cds, alternatively spliced. KC415005 - Homo sapiens mitochondrial antiviral signaling protein (MAVS) mRNA, complete cds; nuclear gene for mitochondrial product. AL833736 - Homo sapiens mRNA; cDNA DKFZp666M015 (from clone DKFZp666M015). JD520185 - Sequence 501209 from Patent EP1572962. JD540916 - Sequence 521940 from Patent EP1572962. JD284759 - Sequence 265783 from Patent EP1572962. JD079873 - Sequence 60897 from Patent EP1572962. JD396562 - Sequence 377586 from Patent EP1572962. JD143295 - Sequence 124319 from Patent EP1572962. JD202154 - Sequence 183178 from Patent EP1572962. JD084991 - Sequence 66015 from Patent EP1572962. JD090136 - Sequence 71160 from Patent EP1572962. JD339972 - Sequence 320996 from Patent EP1572962. JD163987 - Sequence 145011 from Patent EP1572962. JD253878 - Sequence 234902 from Patent EP1572962. JD276132 - Sequence 257156 from Patent EP1572962. JD469564 - Sequence 450588 from Patent EP1572962. JD283479 - Sequence 264503 from Patent EP1572962. JD536726 - Sequence 517750 from Patent EP1572962. JD275102 - Sequence 256126 from Patent EP1572962. JD409842 - Sequence 390866 from Patent EP1572962. JD443977 - Sequence 425001 from Patent EP1572962. JD400199 - Sequence 381223 from Patent EP1572962. JD401438 - Sequence 382462 from Patent EP1572962. JD344581 - Sequence 325605 from Patent EP1572962. JD282573 - Sequence 263597 from Patent EP1572962. JD310057 - Sequence 291081 from Patent EP1572962. JD187720 - Sequence 168744 from Patent EP1572962. JD173153 - Sequence 154177 from Patent EP1572962. JD383782 - Sequence 364806 from Patent EP1572962. JD262729 - Sequence 243753 from Patent EP1572962. JD392269 - Sequence 373293 from Patent EP1572962. JD546004 - Sequence 527028 from Patent EP1572962. JD492412 - Sequence 473436 from Patent EP1572962. JD233791 - Sequence 214815 from Patent EP1572962. JD551071 - Sequence 532095 from Patent EP1572962. JD367907 - Sequence 348931 from Patent EP1572962. JD273537 - Sequence 254561 from Patent EP1572962. JD533482 - Sequence 514506 from Patent EP1572962. JD343685 - Sequence 324709 from Patent EP1572962. JD483545 - Sequence 464569 from Patent EP1572962. JD454916 - Sequence 435940 from Patent EP1572962. JD074714 - Sequence 55738 from Patent EP1572962. JD098890 - Sequence 79914 from Patent EP1572962. JD511987 - Sequence 493011 from Patent EP1572962. JD423301 - Sequence 404325 from Patent EP1572962. JD120756 - Sequence 101780 from Patent EP1572962. JD193241 - Sequence 174265 from Patent EP1572962. JD513321 - Sequence 494345 from Patent EP1572962. JD093563 - Sequence 74587 from Patent EP1572962. JD354752 - Sequence 335776 from Patent EP1572962. JD257570 - Sequence 238594 from Patent EP1572962. JD558702 - Sequence 539726 from Patent EP1572962. JD532201 - Sequence 513225 from Patent EP1572962. JD442831 - Sequence 423855 from Patent EP1572962. JD335193 - Sequence 316217 from Patent EP1572962. JD456776 - Sequence 437800 from Patent EP1572962. JD386832 - Sequence 367856 from Patent EP1572962. JD382064 - Sequence 363088 from Patent EP1572962. JD201355 - Sequence 182379 from Patent EP1572962. JD437136 - Sequence 418160 from Patent EP1572962. JD241677 - Sequence 222701 from Patent EP1572962. JD352016 - Sequence 333040 from Patent EP1572962. JD257636 - Sequence 238660 from Patent EP1572962. JD143972 - Sequence 124996 from Patent EP1572962. JD269545 - Sequence 250569 from Patent EP1572962. JD452560 - Sequence 433584 from Patent EP1572962. JD366128 - Sequence 347152 from Patent EP1572962. JD148741 - Sequence 129765 from Patent EP1572962. JD250963 - Sequence 231987 from Patent EP1572962. JD250964 - Sequence 231988 from Patent EP1572962. JD095398 - Sequence 76422 from Patent EP1572962. JD103412 - Sequence 84436 from Patent EP1572962. JD055583 - Sequence 36607 from Patent EP1572962. JD422542 - Sequence 403566 from Patent EP1572962. JD178610 - Sequence 159634 from Patent EP1572962. JD466467 - Sequence 447491 from Patent EP1572962. JD061223 - Sequence 42247 from Patent EP1572962. JD069681 - Sequence 50705 from Patent EP1572962. JD206942 - Sequence 187966 from Patent EP1572962. JD423013 - Sequence 404037 from Patent EP1572962. JD407847 - Sequence 388871 from Patent EP1572962. JD073302 - Sequence 54326 from Patent EP1572962. JD067165 - Sequence 48189 from Patent EP1572962. JD362579 - Sequence 343603 from Patent EP1572962. JD494192 - Sequence 475216 from Patent EP1572962. JD547185 - Sequence 528209 from Patent EP1572962. JD381205 - Sequence 362229 from Patent EP1572962. JD422008 - Sequence 403032 from Patent EP1572962. JD266371 - Sequence 247395 from Patent EP1572962. JD286653 - Sequence 267677 from Patent EP1572962. JD511494 - Sequence 492518 from Patent EP1572962. JD564365 - Sequence 545389 from Patent EP1572962. JD558287 - Sequence 539311 from Patent EP1572962. JD105544 - Sequence 86568 from Patent EP1572962. JD158720 - Sequence 139744 from Patent EP1572962. JD275615 - Sequence 256639 from Patent EP1572962. JD208572 - Sequence 189596 from Patent EP1572962. JD280833 - Sequence 261857 from Patent EP1572962. JD103373 - Sequence 84397 from Patent EP1572962. JD329936 - Sequence 310960 from Patent EP1572962. JD173718 - Sequence 154742 from Patent EP1572962. JD373287 - Sequence 354311 from Patent EP1572962. JD063438 - Sequence 44462 from Patent EP1572962. JD357892 - Sequence 338916 from Patent EP1572962. JD554357 - Sequence 535381 from Patent EP1572962. JD377279 - Sequence 358303 from Patent EP1572962. JD087519 - Sequence 68543 from Patent EP1572962. JD529281 - Sequence 510305 from Patent EP1572962. JD169432 - Sequence 150456 from Patent EP1572962. JD169433 - Sequence 150457 from Patent EP1572962. JD041448 - Sequence 22472 from Patent EP1572962. JD458035 - Sequence 439059 from Patent EP1572962. JD138475 - Sequence 119499 from Patent EP1572962. JD176560 - Sequence 157584 from Patent EP1572962. JD066823 - Sequence 47847 from Patent EP1572962. JD184207 - Sequence 165231 from Patent EP1572962. JD093090 - Sequence 74114 from Patent EP1572962. JD561444 - Sequence 542468 from Patent EP1572962. JD282011 - Sequence 263035 from Patent EP1572962. JD230123 - Sequence 211147 from Patent EP1572962. JD060144 - Sequence 41168 from Patent EP1572962. JD140415 - Sequence 121439 from Patent EP1572962. AK056260 - Homo sapiens cDNA FLJ31698 fis, clone NT2RI2005966. JD136101 - Sequence 117125 from Patent EP1572962. JD243165 - Sequence 224189 from Patent EP1572962. JD238308 - Sequence 219332 from Patent EP1572962. JD224429 - Sequence 205453 from Patent EP1572962. JD239725 - Sequence 220749 from Patent EP1572962. JD321104 - Sequence 302128 from Patent EP1572962. JD388288 - Sequence 369312 from Patent EP1572962. JD352571 - Sequence 333595 from Patent EP1572962. JD414568 - Sequence 395592 from Patent EP1572962. JD321565 - Sequence 302589 from Patent EP1572962. JD131754 - Sequence 112778 from Patent EP1572962. JD414569 - Sequence 395593 from Patent EP1572962. JD514499 - Sequence 495523 from Patent EP1572962. JD371354 - Sequence 352378 from Patent EP1572962. JD337750 - Sequence 318774 from Patent EP1572962. JD337752 - Sequence 318776 from Patent EP1572962. JD337753 - Sequence 318777 from Patent EP1572962. JD463311 - Sequence 444335 from Patent EP1572962. JD463312 - Sequence 444336 from Patent EP1572962. JD463313 - Sequence 444337 from Patent EP1572962. BC040930 - Homo sapiens cDNA clone IMAGE:4524828, partial cds. BC062310 - Homo sapiens cDNA clone IMAGE:3954377, partial cds. JD498067 - Sequence 479091 from Patent EP1572962. JD376151 - Sequence 357175 from Patent EP1572962. JD498068 - Sequence 479092 from Patent EP1572962. AK095370 - Homo sapiens cDNA FLJ38051 fis, clone CTONG2014389. BC052583 - Homo sapiens hypothetical protein MGC3260, mRNA (cDNA clone IMAGE:6269444), partial cds. JD139156 - Sequence 120180 from Patent EP1572962. JD446764 - Sequence 427788 from Patent EP1572962. BC000073 - Homo sapiens hypothetical protein MGC3260, mRNA (cDNA clone IMAGE:3506265), partial cds. AL390136 - Homo sapiens mRNA; cDNA DKFZp547C224 (from clone DKFZp547C224). AK092705 - Homo sapiens cDNA FLJ35386 fis, clone SKNMC1000016. JD144672 - Sequence 125696 from Patent EP1572962. JD543124 - Sequence 524148 from Patent EP1572962. JD478459 - Sequence 459483 from Patent EP1572962. BC040719 - Homo sapiens, clone IMAGE:6056487, mRNA. JD195115 - Sequence 176139 from Patent EP1572962. BC063593 - Homo sapiens cDNA clone IMAGE:4524567, partial cds. JD277362 - Sequence 258386 from Patent EP1572962. JD492971 - Sequence 473995 from Patent EP1572962. JD272778 - Sequence 253802 from Patent EP1572962. JD241236 - Sequence 222260 from Patent EP1572962. JD158530 - Sequence 139554 from Patent EP1572962. JD158531 - Sequence 139555 from Patent EP1572962. JD236988 - Sequence 218012 from Patent EP1572962. JD174984 - Sequence 156008 from Patent EP1572962. BC028962 - Homo sapiens cDNA clone IMAGE:4991182. DQ590452 - Homo sapiens piRNA piR-57564, complete sequence. JD308571 - Sequence 289595 from Patent EP1572962. JD059476 - Sequence 40500 from Patent EP1572962. JD053529 - Sequence 34553 from Patent EP1572962. JD380154 - Sequence 361178 from Patent EP1572962. JD120658 - Sequence 101682 from Patent EP1572962. JD251423 - Sequence 232447 from Patent EP1572962. JD310649 - Sequence 291673 from Patent EP1572962. JD511016 - Sequence 492040 from Patent EP1572962. JD438607 - Sequence 419631 from Patent EP1572962. JD313159 - Sequence 294183 from Patent EP1572962. JD251657 - Sequence 232681 from Patent EP1572962. JD077032 - Sequence 58056 from Patent EP1572962. JD060745 - Sequence 41769 from Patent EP1572962. JD502322 - Sequence 483346 from Patent EP1572962. JD456359 - Sequence 437383 from Patent EP1572962. JD491553 - Sequence 472577 from Patent EP1572962. JD184266 - Sequence 165290 from Patent EP1572962. JD221557 - Sequence 202581 from Patent EP1572962. JD121194 - Sequence 102218 from Patent EP1572962. JD148792 - Sequence 129816 from Patent EP1572962. JD284749 - Sequence 265773 from Patent EP1572962. JD301169 - Sequence 282193 from Patent EP1572962. JD425563 - Sequence 406587 from Patent EP1572962. JD377704 - Sequence 358728 from Patent EP1572962. JD135931 - Sequence 116955 from Patent EP1572962. JD047781 - Sequence 28805 from Patent EP1572962. JD204846 - Sequence 185870 from Patent EP1572962. JD266522 - Sequence 247546 from Patent EP1572962. JD500549 - Sequence 481573 from Patent EP1572962. JD556479 - Sequence 537503 from Patent EP1572962. JD441478 - Sequence 422502 from Patent EP1572962. JD267241 - Sequence 248265 from Patent EP1572962. JD182253 - Sequence 163277 from Patent EP1572962. JD511145 - Sequence 492169 from Patent EP1572962. JD243118 - Sequence 224142 from Patent EP1572962. JD479537 - Sequence 460561 from Patent EP1572962. JD564637 - Sequence 545661 from Patent EP1572962. JD558886 - Sequence 539910 from Patent EP1572962. JD408221 - Sequence 389245 from Patent EP1572962. JD510935 - Sequence 491959 from Patent EP1572962. JD088661 - Sequence 69685 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q7Z434 (Reactome details) participates in the following event(s):
R-HSA-168909 viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS R-HSA-936564 NLRX1 inhibits MAVS-DDX58 interaction. R-HSA-168934 MAVS interacts with RIPK1 and FADD R-HSA-918227 Recruitment of TRAF3 to MAVS R-HSA-918230 Recruitment of TRAF6/TRAF2 to IPS-1 R-HSA-990528 Interaction of PCBP2 with MAVS R-HSA-936378 Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS R-HSA-918225 TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 R-HSA-936381 OTUD5 deubiquitinates TRAF3 R-HSA-933526 Recruitment of caspase-8 and -10 to FADD complex R-HSA-990526 Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1 R-HSA-933528 Interaction of MEKK1 with TRAF6 R-HSA-933537 Recruitment of TANK to TRAF6 R-HSA-933539 Recruitment of IKK complex R-HSA-918232 Recruitment of IRF3,IRF7 R-HSA-918229 Phosphorylation and release of IRF3/IRF7 R-HSA-933523 Dimerzation of procaspase-8, procaspase-10 R-HSA-933527 Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 R-HSA-933532 Processing of caspases R-HSA-933538 Recruitment of IRF7 to TRAF6 R-HSA-933525 Phosphorylation and release of IRF7 R-HSA-933530 Activation of IKK by MEKK1 R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-918233 TRAF3-dependent IRF activation pathway R-HSA-933541 TRAF6 mediated IRF7 activation R-HSA-168249 Innate Immune System R-HSA-5689896 Ovarian tumor domain proteases R-HSA-933542 TRAF6 mediated NF-kB activation R-HSA-168256 Immune System R-HSA-5688426 Deubiquitination R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
