Human Gene MAX (ENST00000358664.9_9) from GENCODE V47lift37
Description: Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. (from UniProt P61244) Gencode Transcript: ENST00000358664.9_9 Gencode Gene: ENSG00000125952.21_16 Transcript (Including UTRs) Position: hg19 chr14:65,541,845-65,569,235 Size: 27,391 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr14:65,543,194-65,569,057 Size: 25,864 Coding Exon Count: 5
ID:MAX_HUMAN DESCRIPTION: RecName: Full=Protein max; AltName: Full=Class D basic helix-loop-helix protein 4; Short=bHLHd4; AltName: Full=Myc-associated factor X; FUNCTION: Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. INTERACTION: Q99814:EPAS1; NbExp=2; IntAct=EBI-751711, EBI-447470; P02794:FTH1; NbExp=2; IntAct=EBI-751711, EBI-713259; Q9UBS5:GABBR1; NbExp=3; IntAct=EBI-751711, EBI-724156; Q9Y6D9:MAD1L1; NbExp=2; IntAct=EBI-751711, EBI-742610; P01106:MYC; NbExp=21; IntAct=EBI-751711, EBI-447544; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle. PTM: Reversible lysine acetylation might regulate the nuclear- cytoplasmic shuttling of specific Max complexes. SIMILARITY: Belongs to the MAX family. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P61244
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003712 transcription cofactor activity GO:0003713 transcription coactivator activity GO:0005515 protein binding GO:0042803 protein homodimerization activity GO:0043565 sequence-specific DNA binding GO:0044877 macromolecular complex binding GO:0046982 protein heterodimerization activity GO:0046983 protein dimerization activity GO:0070888 E-box binding GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Biological Process: GO:0000082 G1/S transition of mitotic cell cycle GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0009267 cellular response to starvation GO:0010243 response to organonitrogen compound GO:0010629 negative regulation of gene expression GO:0032868 response to insulin GO:0048678 response to axon injury GO:0051402 neuron apoptotic process GO:0060041 retina development in camera-type eye GO:0065003 macromolecular complex assembly GO:0070317 negative regulation of G0 to G1 transition GO:0071375 cellular response to peptide hormone stimulus
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