ID:MAZ_HUMAN DESCRIPTION: RecName: Full=Myc-associated zinc finger protein; Short=MAZI; AltName: Full=Pur-1; AltName: Full=Purine-binding transcription factor; AltName: Full=Transcription factor Zif87; AltName: Full=ZF87; AltName: Full=Zinc finger protein 801; FUNCTION: May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. SUBUNIT: Interacts with BPTF. INTERACTION: P43146:DCC; NbExp=4; IntAct=EBI-1809742, EBI-1222919; P70211:Dcc (xeno); NbExp=2; IntAct=EBI-1809742, EBI-1798863; Q91562:dcc (xeno); NbExp=2; IntAct=EBI-1809742, EBI-1809954; SUBCELLULAR LOCATION: Nucleus (Probable). Note=In brains of Alzheimer disease patients, present in a plaque-like structures. TISSUE SPECIFICITY: Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level). SIMILARITY: Contains 6 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=AAB04121.1; Type=Erroneous initiation; Sequence=BAA12728.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P56270
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003723 RNA binding GO:0005515 protein binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006369 termination of RNA polymerase II transcription
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
