ID:MCL1_HUMAN DESCRIPTION: RecName: Full=Induced myeloid leukemia cell differentiation protein Mcl-1; AltName: Full=Bcl-2-like protein 3; Short=Bcl2-L-3; AltName: Full=Bcl-2-related protein EAT/mcl1; AltName: Full=mcl1/EAT; FUNCTION: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. SUBUNIT: Interacts with BAD, BOK, BIK and BFM (By similarity). Interacts with PMAIP1. Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins. INTERACTION: Q16611:BAK1; NbExp=6; IntAct=EBI-1003422, EBI-519866; Q07812:BAX; NbExp=3; IntAct=EBI-1003422, EBI-516580; Q9BXH1:BBC3; NbExp=3; IntAct=EBI-1003422, EBI-519884; O43521:BCL2L11; NbExp=6; IntAct=EBI-1003422, EBI-526406; Q03135:CAV1; NbExp=3; IntAct=EBI-1003422, EBI-603614; P49817:Cav1 (xeno); NbExp=3; IntAct=EBI-1003422, EBI-1161338; Q13794:PMAIP1; NbExp=4; IntAct=EBI-1003422, EBI-707392; Q9JM54:Pmaip1 (xeno); NbExp=2; IntAct=EBI-1003422, EBI-709183; SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria. INDUCTION: Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation. PTM: Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment. PTM: Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. PTM: Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. SIMILARITY: Belongs to the Bcl-2 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mcl1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q07820
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008320 protein transmembrane transporter activity GO:0042803 protein homodimerization activity GO:0046982 protein heterodimerization activity GO:0051434 BH3 domain binding
Biological Process: GO:0001709 cell fate determination GO:0006915 apoptotic process GO:0007275 multicellular organism development GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008637 apoptotic mitochondrial changes GO:0010507 negative regulation of autophagy GO:0019221 cytokine-mediated signaling pathway GO:0019725 cellular homeostasis GO:0030154 cell differentiation GO:0034097 response to cytokine GO:0042981 regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0071806 protein transmembrane transport GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:2000811 negative regulation of anoikis GO:2001020 regulation of response to DNA damage stimulus GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
