The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48163
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006090 pyruvate metabolic process GO:0006108 malate metabolic process GO:0006741 NADP biosynthetic process GO:0009725 response to hormone GO:0009743 response to carbohydrate GO:0019216 regulation of lipid metabolic process GO:0022900 electron transport chain GO:0051262 protein tetramerization GO:0055114 oxidation-reduction process GO:1902031 regulation of NADP metabolic process
LP747427 - Sequence 14 from Patent WO2018009939. AK289783 - Homo sapiens cDNA FLJ76221 complete cds, highly similar to Homo sapiens malic enzyme 1, NADP(+)-dependent, cytosolic (ME1), mRNA. U43944 - Human breast cancer cytosolic NADP(+)-dependent malic enzyme mRNA, partial cds. AK301875 - Homo sapiens cDNA FLJ57648 complete cds, highly similar to NADP-dependent malic enzyme (EC 1.1.1.40). X77244 - H.sapiens NADP+ dependent cytoplasmic malic enzyme mRNA. AK223417 - Homo sapiens mRNA for cytosolic malic enzyme 1 variant, clone: FCC109G08. AK302777 - Homo sapiens cDNA FLJ57677 complete cds, highly similar to NADP-dependent malic enzyme (EC 1.1.1.40). BC025246 - Homo sapiens malic enzyme 1, NADP(+)-dependent, cytosolic, mRNA (cDNA clone MGC:39115 IMAGE:4870714), complete cds. L34035 - Homo sapiens NADP-dependent malic enzyme mRNA, complete cds. DQ892155 - Synthetic construct clone IMAGE:100004785; FLH183523.01X; RZPDo839D07142D malic enzyme 1, NADP(+)-dependent, cytosolic (ME1) gene, encodes complete protein. EU176687 - Synthetic construct Homo sapiens clone IMAGE:100011462; FLH183522.01L; RZPDo839H03255D malic enzyme 1, NADP(+)-dependent, cytosolic (ME1) gene, encodes complete protein. AB528430 - Synthetic construct DNA, clone: pF1KB3236, Homo sapiens ME1 gene for malic enzyme 1, NADP(+)-dependent, cytosolic, without stop codon, in Flexi system. MB486567 - JP 2019531699-A/14: METHODS FOR DIAGNOSING AND TREATING CANCER. AJ420574 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1644933. BC017403 - Homo sapiens, clone IMAGE:4290619, mRNA, partial cds. JD234864 - Sequence 215888 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCyc Knowledge Library MALATE-ASPARTATE-SHUTTLE-PWY - malate-aspartate shuttle PWY66-398 - TCA cycle PWY66-399 - gluconeogenesis PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
Reactome (by CSHL, EBI, and GO)
Protein P48163 (Reactome details) participates in the following event(s):
R-HSA-9012036 ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR R-HSA-1989781 PPARA activates gene expression R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism R-HSA-70268 Pyruvate metabolism R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport