Human Gene MECP2 (ENST00000453960.7_11) from GENCODE V47lift37
  Description: methyl-CpG binding protein 2, transcript variant 10 (from RefSeq NM_001386139.1)
Gencode Transcript: ENST00000453960.7_11
Gencode Gene: ENSG00000169057.26_21
Transcript (Including UTRs)
   Position: hg19 chrX:153,287,024-153,363,174 Size: 76,151 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chrX:153,295,818-153,363,122 Size: 67,305 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:153,287,024-153,363,174)mRNA (may differ from genome)Protein (498 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsHGNCHuman Cortex Gene Expression
MalacardsMGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MECP2_HUMAN
DESCRIPTION: RecName: Full=Methyl-CpG-binding protein 2; Short=MeCp-2 protein; Short=MeCp2;
FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A.
SUBUNIT: Interacts with FNBP3 (By similarity). Interacts with CDKL5.
INTERACTION: P51531:SMARCA2; NbExp=4; IntAct=EBI-1189067, EBI-679562;
SUBCELLULAR LOCATION: Nucleus. Note=Colocalized with methyl-CpG in the genome.
TISSUE SPECIFICITY: Present in all adult somatic tissues tested.
PTM: Phosphorylated on Ser-423 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation (By similarity).
DISEASE: Defects in MECP2 may be a cause of Angelman syndrome (AS) [MIM:105830]; also known as happy puppet syndrome. AS is a neurodevelopmental disorder characterized by severe mental retardation, absent speech, ataxia, sociable affect and dysmorphic facial features. AS and Rett syndrome have overlapping clinical features.
DISEASE: Defects in MECP2 are the cause of mental retardation syndromic X-linked type 13 (MRXS13) [MIM:300055]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRXS13 patients manifest mental retardation associated with other variable features such as spasticity, episodes of manic depressive psychosis, increased tone and macroorchidism.
DISEASE: Defects in MECP2 are the cause of Rett syndrome (RTT) [MIM:312750]. RTT is an X-linked dominant disease, it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age, then gradually lose speech and purposeful hand movements and develop microcephaly, seizures, autism, ataxia, intermittent hyperventilation, and stereotypic hand movements. After initial regression, the condition stabilizes and patients usually survive into adulthood.
DISEASE: Defects in MECP2 may be the cause of susceptibility autism X-linked type 3 (AUTSX3) [MIM:300496]. AUTSX3 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age.
DISEASE: Defects in MECP2 are the cause of encephalopathy neonatal severe due to MECP2 mutations (ENS-MECP2) [MIM:300673]. Note=The MECP2 gene is mutated in Rett syndrome, a severe neurodevelopmental disorder that almost always occurs in females. Although it was first thought that MECP2 mutations causing Rett syndrome were lethal in males, later reports identified a severe neonatal encephalopathy in surviving male sibs of patients with Rett syndrome. Additional reports have confirmed a severe phenotype in males with Rett syndrome-associated MECP2 mutations.
DISEASE: Defects in MECP2 are the cause of mental retardation syndromic X-linked Lubs type (MRXSL) [MIM:300260]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRXSL patients manifest mental retardation associated with variable features. They include swallowing dysfunction and gastroesophageal reflux with secondary recurrent respiratory infections, hypotonia, mild myopathy and characteristic facies such as downslanting palpebral fissures, hypertelorism and a short nose with a low nasal bridge. Note=Increased dosage of MECP2 due to gene duplication appears to be responsible for the mental retardation phenotype.
SIMILARITY: Contains 2 A.T hook DNA-binding domains.
SIMILARITY: Contains 1 MBD (methyl-CpG-binding) domain.
SEQUENCE CAUTION: Sequence=CAD97991.1; Type=Erroneous initiation;
WEB RESOURCE: Name=RettBASE; Note=IRSA MECP2 variation database; URL="http://mecp2.chw.edu.au/mecp2/";
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MECP2";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MECP2
Diseases sorted by gene-association score: mental retardation, x-linked, syndromic 13* (1711), rett syndrome* (1687), encephalopathy, neonatal severe* (1278), mental retardation, x-linked syndromic, lubs type* (1028), autism susceptibility, x-linked 3* (975), mecp2-related severe neonatal encephalopathy* (400), angelman syndrome* (332), attention deficit-hyperactivity disorder* (239), alacrima, achalasia, and mental retardation syndrome* (141), intellectual disability* (129), mecp2-related disorders* (100), mecp2-related angelman-like syndrome* (100), x-linked non-specific intellectual disability* (90), pervasive developmental disorder (47), classic rett syndrome (19), bruxism (15), autistic disorder (14), learning disability (13), fragile x syndrome (13), encephalopathy (11), kbg syndrome (10), disease of mental health (10), immunodeficiency-centromeric instability-facial anomalies syndrome (9), infantile hypotonia (8), gait apraxia (8), hypotonia (8), progressive multifocal leukoencephalopathy (7), spasticity (7), stereotypic movement disorder (6), specific developmental disorder (6), wagr syndrome (6), autism spectrum disorder (6), speech and communication disorders (6), syndromic x-linked intellectual disability (5), renpenning syndrome (5), west syndrome (5), meningoencephalitis (4), epileptic encephalopathy, early infantile, 9 (4), partington syndrome (4), mental retardation and microcephaly with pontine and cerebellar hypoplasia (4), microcephaly (3), seizure disorder (3), scoliosis (2), bone structure disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.94 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 403.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.0052-0.346 Picture PostScript Text
3' UTR -3075.708794-0.350 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017956 - AT_hook_DNA-bd_motif
IPR016177 - DNA-bd_integrase-typ
IPR017353 - Me_CpG-bd_MeCP2
IPR001739 - Methyl_CpG_DNA-bd

Pfam Domains:
PF01429 - Methyl-CpG binding domain

SCOP Domains:
81296 - E set domains
54171 - DNA-binding domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1QK9 - NMR MuPIT 3C2I - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P51608
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008327 methyl-CpG binding
GO:0010385 double-stranded methylated DNA binding
GO:0019904 protein domain specific binding
GO:0035197 siRNA binding
GO:0047485 protein N-terminus binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001662 behavioral fear response
GO:0001666 response to hypoxia
GO:0001964 startle response
GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure
GO:0002087 regulation of respiratory gaseous exchange by neurological system process
GO:0006020 inositol metabolic process
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0006342 chromatin silencing
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006541 glutamine metabolic process
GO:0006576 cellular biogenic amine metabolic process
GO:0007052 mitotic spindle organization
GO:0007268 chemical synaptic transmission
GO:0007416 synapse assembly
GO:0007420 brain development
GO:0007585 respiratory gaseous exchange
GO:0007612 learning
GO:0007613 memory
GO:0007616 long-term memory
GO:0007626 locomotory behavior
GO:0008104 protein localization
GO:0008211 glucocorticoid metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0009314 response to radiation
GO:0009405 pathogenesis
GO:0009791 post-embryonic development
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016358 dendrite development
GO:0016525 negative regulation of angiogenesis
GO:0016571 histone methylation
GO:0016573 histone acetylation
GO:0019230 proprioception
GO:0019233 sensory perception of pain
GO:0021549 cerebellum development
GO:0021591 ventricular system development
GO:0030182 neuron differentiation
GO:0031061 negative regulation of histone methylation
GO:0031175 neuron projection development
GO:0032048 cardiolipin metabolic process
GO:0033555 multicellular organismal response to stress
GO:0035067 negative regulation of histone acetylation
GO:0035176 social behavior
GO:0040029 regulation of gene expression, epigenetic
GO:0042551 neuron maturation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046470 phosphatidylcholine metabolic process
GO:0048167 regulation of synaptic plasticity
GO:0050432 catecholamine secretion
GO:0050884 neuromuscular process controlling posture
GO:0050905 neuromuscular process
GO:0051151 negative regulation of smooth muscle cell differentiation
GO:0051965 positive regulation of synapse assembly
GO:0060079 excitatory postsynaptic potential
GO:0060291 long-term synaptic potentiation
GO:0090063 positive regulation of microtubule nucleation
GO:1900114 positive regulation of histone H3-K9 trimethylation
GO:1905643 positive regulation of DNA methylation
GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation

Cellular Component:
GO:0000792 heterochromatin
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0098794 postsynapse
GO:0000930 gamma-tubulin complex
GO:0005813 centrosome


-  Descriptions from all associated GenBank mRNAs
  AJ132917 - Homo sapiens mRNA for methyl-CpG-binding protein 2.
AF158180 - Homo sapiens methyl CpG binding protein 2 (MECP2) mRNA, complete cds.
GQ203293 - Homo sapiens truncated methyl CpG binding protein 2 transcript 1 (MECP2) mRNA, complete cds, alternatively spliced.
GQ203294 - Homo sapiens mutant methyl CpG binding protein 2 transcript variant 1 (MECP2) mRNA, complete cds, alternatively spliced.
GQ203295 - Homo sapiens methyl CpG binding protein 2-like (MECP2) mRNA, complete sequence, alternatively spliced.
GQ896382 - Homo sapiens methyl CpG binding protein 2 isoform 1 (MECP2) mRNA, complete cds.
GU479943 - Homo sapiens clone MS1923 methyl CpG binding protein 2 (MECP2) mRNA, complete cds, alternatively spliced.
HM020402 - Homo sapiens isolate RS114 mutant methyl CpG binding protein 2 (MECP2) mRNA, complete cds.
HM156732 - Homo sapiens clone RS125 mutant methyl CpG binding protein 2 transcript 1 (MECP2) mRNA, complete cds.
HM156733 - Homo sapiens clone AD mutant methyl CpG binding protein 2 transcript 1 (MECP2) mRNA, complete cds.
HQ141378 - Homo sapiens mutant methyl CpG binding protein 2 variant 1 (MECP2) mRNA, complete cds, alternatively spliced.
HQ154629 - Homo sapiens methyl CpG binding protein 2 transcript variant 1 (MECP2) mRNA, complete cds.
AB209464 - Homo sapiens mRNA for methyl CpG binding protein 2 variant protein.
BC011612 - Homo sapiens methyl CpG binding protein 2 (Rett syndrome), mRNA (cDNA clone MGC:10245 IMAGE:3956518), complete cds.
BX538060 - Homo sapiens mRNA; cDNA DKFZp686A24160 (from clone DKFZp686A24160).
AK289444 - Homo sapiens cDNA FLJ75240 complete cds, highly similar to Homo sapiens methyl CpG binding protein 2 (MECP2) mRNA.
Y12643 - H.sapiens mRNA for methyl-CpG-binding protein 2.
L37298 - Homo sapiens methyl-CpG-binding protein (MeCP-2) mRNA, complete cds.
HM005664 - Homo sapiens clone HTL-T-41a testis tissue sperm-binding protein Li 41a mRNA, complete cds.
GU812285 - Homo sapiens truncated methyl CpG binding protein 2 transcript 1 (MECP2) mRNA, complete cds, alternatively spliced.
GU812286 - Homo sapiens methyl CpG binding protein 2 transcript 1 (MECP2) mRNA, complete cds, alternatively spliced.
HQ127345 - Homo sapiens isolate R19 mutant methyl CpG binding protein 2 (MECP2) mRNA, complete cds.
HQ141377 - Homo sapiens mutant methyl CpG binding protein 2 (MECP2) mRNA, complete cds, alternatively spliced.
AY541280 - Homo sapiens methyl CpG binding protein 2 isoform B (MECP2) mRNA, complete cds.
KJ891601 - Synthetic construct Homo sapiens clone ccsbBroadEn_00995 MECP2 gene, encodes complete protein.
KR710306 - Synthetic construct Homo sapiens clone CCSBHm_00011287 MECP2 (MECP2) mRNA, encodes complete protein.
KR710307 - Synthetic construct Homo sapiens clone CCSBHm_00011371 MECP2 (MECP2) mRNA, encodes complete protein.
DQ891939 - Synthetic construct clone IMAGE:100004569; FLH181592.01X; RZPDo839F01136D methyl CpG binding protein 2 (Rett syndrome) (MECP2) gene, encodes complete protein.
EU176656 - Synthetic construct Homo sapiens clone IMAGE:100011449; FLH181591.01L; RZPDo839E11254D methyl CpG binding protein 2 (Rett syndrome) (MECP2) gene, encodes complete protein.
X99686 - H.sapiens mRNA for methyl-CpG-binding protein 2.
KU178174 - Homo sapiens methyl CpG binding protein 2 isoform 1 (MECP2) mRNA, partial cds.
KU178175 - Homo sapiens methyl CpG binding protein 2 isoform 2 (MECP2) mRNA, complete cds, alternatively spliced.
KU178176 - Homo sapiens methyl CpG binding protein 2 isoform 3 (MECP2) mRNA, partial cds, alternatively spliced.
KU178177 - Homo sapiens methyl CpG binding protein 2 isoform 5 (MECP2) mRNA, complete cds, alternatively spliced.
KU178178 - Homo sapiens methyl CpG binding protein 2 isoform 6 (MECP2) mRNA, partial cds, alternatively spliced.
KU178179 - Homo sapiens methyl CpG binding protein 2 isoform 7 (MECP2) mRNA, complete cds, alternatively spliced.
KU178180 - Homo sapiens methyl CpG binding protein 2 isoform 8 (MECP2) mRNA, partial cds, alternatively spliced.
AB463883 - Synthetic construct DNA, clone: pF1KB8317, Homo sapiens MECP2 gene for methyl CpG binding protein 2, without stop codon, in Flexi system.
AM392557 - Synthetic construct Homo sapiens clone IMAGE:100002051 for hypothetical protein (MECP2 gene).
CU679986 - Synthetic construct Homo sapiens gateway clone IMAGE:100017355 5' read MECP2 mRNA.
DQ656049 - Homo sapiens clone UGL112-B-D5, mRNA sequence.
DQ656051 - Homo sapiens clone UGL112-B-E5, mRNA sequence.
JD179821 - Sequence 160845 from Patent EP1572962.
JD466198 - Sequence 447222 from Patent EP1572962.
JD045377 - Sequence 26401 from Patent EP1572962.
JD127710 - Sequence 108734 from Patent EP1572962.
JD254350 - Sequence 235374 from Patent EP1572962.
JD051190 - Sequence 32214 from Patent EP1572962.
JD278429 - Sequence 259453 from Patent EP1572962.
JD405336 - Sequence 386360 from Patent EP1572962.
JD480624 - Sequence 461648 from Patent EP1572962.
JD123317 - Sequence 104341 from Patent EP1572962.
JD122567 - Sequence 103591 from Patent EP1572962.
JD063803 - Sequence 44827 from Patent EP1572962.
JD164155 - Sequence 145179 from Patent EP1572962.
JD353800 - Sequence 334824 from Patent EP1572962.
JD332815 - Sequence 313839 from Patent EP1572962.
JD466510 - Sequence 447534 from Patent EP1572962.
JD232969 - Sequence 213993 from Patent EP1572962.
JD205694 - Sequence 186718 from Patent EP1572962.
JD450147 - Sequence 431171 from Patent EP1572962.
JD036761 - Sequence 17785 from Patent EP1572962.
JD549240 - Sequence 530264 from Patent EP1572962.
JD118498 - Sequence 99522 from Patent EP1572962.
JD350572 - Sequence 331596 from Patent EP1572962.
JD258583 - Sequence 239607 from Patent EP1572962.
JD394367 - Sequence 375391 from Patent EP1572962.
JD427919 - Sequence 408943 from Patent EP1572962.
JD157673 - Sequence 138697 from Patent EP1572962.
JD216046 - Sequence 197070 from Patent EP1572962.
JD258719 - Sequence 239743 from Patent EP1572962.
JD101059 - Sequence 82083 from Patent EP1572962.
JD340234 - Sequence 321258 from Patent EP1572962.
JD482126 - Sequence 463150 from Patent EP1572962.
JD277406 - Sequence 258430 from Patent EP1572962.
JD425177 - Sequence 406201 from Patent EP1572962.
JD320910 - Sequence 301934 from Patent EP1572962.
JD115725 - Sequence 96749 from Patent EP1572962.
JD426163 - Sequence 407187 from Patent EP1572962.
JD076967 - Sequence 57991 from Patent EP1572962.
JD303519 - Sequence 284543 from Patent EP1572962.
JD433626 - Sequence 414650 from Patent EP1572962.
JD260399 - Sequence 241423 from Patent EP1572962.
JD400217 - Sequence 381241 from Patent EP1572962.
JD378850 - Sequence 359874 from Patent EP1572962.
JD224054 - Sequence 205078 from Patent EP1572962.
JD305603 - Sequence 286627 from Patent EP1572962.
JD161895 - Sequence 142919 from Patent EP1572962.
JD540638 - Sequence 521662 from Patent EP1572962.
JD161492 - Sequence 142516 from Patent EP1572962.
JD376390 - Sequence 357414 from Patent EP1572962.
JD347645 - Sequence 328669 from Patent EP1572962.
JD541141 - Sequence 522165 from Patent EP1572962.
JD277213 - Sequence 258237 from Patent EP1572962.
JD116279 - Sequence 97303 from Patent EP1572962.
JD516478 - Sequence 497502 from Patent EP1572962.
JD370003 - Sequence 351027 from Patent EP1572962.
JD230200 - Sequence 211224 from Patent EP1572962.
JD527617 - Sequence 508641 from Patent EP1572962.
BC031833 - Homo sapiens, clone IMAGE:4476493, mRNA, partial cds.
JD284449 - Sequence 265473 from Patent EP1572962.
JD254230 - Sequence 235254 from Patent EP1572962.
JD296114 - Sequence 277138 from Patent EP1572962.
JD424610 - Sequence 405634 from Patent EP1572962.
JD400324 - Sequence 381348 from Patent EP1572962.
JD518683 - Sequence 499707 from Patent EP1572962.
JD390699 - Sequence 371723 from Patent EP1572962.
JD155084 - Sequence 136108 from Patent EP1572962.
JD068174 - Sequence 49198 from Patent EP1572962.
JD370734 - Sequence 351758 from Patent EP1572962.
JD124304 - Sequence 105328 from Patent EP1572962.
JD168217 - Sequence 149241 from Patent EP1572962.
JD318075 - Sequence 299099 from Patent EP1572962.
JD450269 - Sequence 431293 from Patent EP1572962.
JD344419 - Sequence 325443 from Patent EP1572962.
JD537048 - Sequence 518072 from Patent EP1572962.
JD193245 - Sequence 174269 from Patent EP1572962.
JD466130 - Sequence 447154 from Patent EP1572962.
JD195432 - Sequence 176456 from Patent EP1572962.
JD464916 - Sequence 445940 from Patent EP1572962.
JD423788 - Sequence 404812 from Patent EP1572962.
JD399856 - Sequence 380880 from Patent EP1572962.
JD386615 - Sequence 367639 from Patent EP1572962.
JD075619 - Sequence 56643 from Patent EP1572962.
JD222571 - Sequence 203595 from Patent EP1572962.
JD444057 - Sequence 425081 from Patent EP1572962.
JD545619 - Sequence 526643 from Patent EP1572962.
JD531605 - Sequence 512629 from Patent EP1572962.
JD301334 - Sequence 282358 from Patent EP1572962.
JD038666 - Sequence 19690 from Patent EP1572962.
JD551723 - Sequence 532747 from Patent EP1572962.
JD057833 - Sequence 38857 from Patent EP1572962.
JD260210 - Sequence 241234 from Patent EP1572962.
JD103978 - Sequence 85002 from Patent EP1572962.
JD258674 - Sequence 239698 from Patent EP1572962.
JD358273 - Sequence 339297 from Patent EP1572962.
JD099731 - Sequence 80755 from Patent EP1572962.
JD097642 - Sequence 78666 from Patent EP1572962.
JD235429 - Sequence 216453 from Patent EP1572962.
JD465331 - Sequence 446355 from Patent EP1572962.
JD390192 - Sequence 371216 from Patent EP1572962.
JD396610 - Sequence 377634 from Patent EP1572962.
JD126154 - Sequence 107178 from Patent EP1572962.
JD491035 - Sequence 472059 from Patent EP1572962.
JD328519 - Sequence 309543 from Patent EP1572962.
JD246534 - Sequence 227558 from Patent EP1572962.
JD380302 - Sequence 361326 from Patent EP1572962.
JD189229 - Sequence 170253 from Patent EP1572962.
JD405072 - Sequence 386096 from Patent EP1572962.
JD507951 - Sequence 488975 from Patent EP1572962.
JD258312 - Sequence 239336 from Patent EP1572962.
JD415915 - Sequence 396939 from Patent EP1572962.
JD253229 - Sequence 234253 from Patent EP1572962.
JD487329 - Sequence 468353 from Patent EP1572962.
JD315704 - Sequence 296728 from Patent EP1572962.
JD557902 - Sequence 538926 from Patent EP1572962.
JD272516 - Sequence 253540 from Patent EP1572962.
JD484700 - Sequence 465724 from Patent EP1572962.
JD210935 - Sequence 191959 from Patent EP1572962.
JD192820 - Sequence 173844 from Patent EP1572962.
JD298784 - Sequence 279808 from Patent EP1572962.
JD259337 - Sequence 240361 from Patent EP1572962.
JD553494 - Sequence 534518 from Patent EP1572962.
JD402234 - Sequence 383258 from Patent EP1572962.
JD166873 - Sequence 147897 from Patent EP1572962.
JD288086 - Sequence 269110 from Patent EP1572962.
JD552717 - Sequence 533741 from Patent EP1572962.
JD038849 - Sequence 19873 from Patent EP1572962.
JD227027 - Sequence 208051 from Patent EP1572962.
JD219458 - Sequence 200482 from Patent EP1572962.
JD529992 - Sequence 511016 from Patent EP1572962.
JD468078 - Sequence 449102 from Patent EP1572962.
JD377232 - Sequence 358256 from Patent EP1572962.
JD077442 - Sequence 58466 from Patent EP1572962.
JD494221 - Sequence 475245 from Patent EP1572962.
JD548462 - Sequence 529486 from Patent EP1572962.
JD565216 - Sequence 546240 from Patent EP1572962.
JD565338 - Sequence 546362 from Patent EP1572962.
JD389679 - Sequence 370703 from Patent EP1572962.
JD164055 - Sequence 145079 from Patent EP1572962.
JD055007 - Sequence 36031 from Patent EP1572962.
JD172848 - Sequence 153872 from Patent EP1572962.
JD073434 - Sequence 54458 from Patent EP1572962.
JD191845 - Sequence 172869 from Patent EP1572962.
JD258542 - Sequence 239566 from Patent EP1572962.
JD154762 - Sequence 135786 from Patent EP1572962.
JD365987 - Sequence 347011 from Patent EP1572962.
JD252093 - Sequence 233117 from Patent EP1572962.
JD302151 - Sequence 283175 from Patent EP1572962.
JD390766 - Sequence 371790 from Patent EP1572962.
JD266743 - Sequence 247767 from Patent EP1572962.
JD261056 - Sequence 242080 from Patent EP1572962.
JD521129 - Sequence 502153 from Patent EP1572962.
JD163910 - Sequence 144934 from Patent EP1572962.
JD301207 - Sequence 282231 from Patent EP1572962.
JD402241 - Sequence 383265 from Patent EP1572962.
JD298463 - Sequence 279487 from Patent EP1572962.
JD279791 - Sequence 260815 from Patent EP1572962.
JD305663 - Sequence 286687 from Patent EP1572962.
JD435884 - Sequence 416908 from Patent EP1572962.
X89430 - H.sapiens mRNA for methyl CpG binding protein 2.
JD084262 - Sequence 65286 from Patent EP1572962.
JD453166 - Sequence 434190 from Patent EP1572962.
JD540840 - Sequence 521864 from Patent EP1572962.
JD378573 - Sequence 359597 from Patent EP1572962.
JD542076 - Sequence 523100 from Patent EP1572962.
JD178756 - Sequence 159780 from Patent EP1572962.
JD341322 - Sequence 322346 from Patent EP1572962.
JD529027 - Sequence 510051 from Patent EP1572962.
JD317820 - Sequence 298844 from Patent EP1572962.
JD319189 - Sequence 300213 from Patent EP1572962.
JD190547 - Sequence 171571 from Patent EP1572962.
JD214948 - Sequence 195972 from Patent EP1572962.
JD040818 - Sequence 21842 from Patent EP1572962.
JD385825 - Sequence 366849 from Patent EP1572962.
JD126278 - Sequence 107302 from Patent EP1572962.
JD104023 - Sequence 85047 from Patent EP1572962.
JD209298 - Sequence 190322 from Patent EP1572962.
JD108625 - Sequence 89649 from Patent EP1572962.
JD374621 - Sequence 355645 from Patent EP1572962.
JD239916 - Sequence 220940 from Patent EP1572962.
JD207511 - Sequence 188535 from Patent EP1572962.
JD276477 - Sequence 257501 from Patent EP1572962.
JD141677 - Sequence 122701 from Patent EP1572962.
JD336711 - Sequence 317735 from Patent EP1572962.
JD443967 - Sequence 424991 from Patent EP1572962.
JD138631 - Sequence 119655 from Patent EP1572962.
JD461585 - Sequence 442609 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000453960.1, ENST00000453960.2, ENST00000453960.3, ENST00000453960.4, ENST00000453960.5, ENST00000453960.6, MECP2_HUMAN, NM_001386139, O15233, P51608, Q6QHH9, Q7Z384, uc320vdp.1, uc320vdp.2
UCSC ID: ENST00000453960.7_11
RefSeq Accession: NM_001110792.2
Protein: P51608 (aka MECP2_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene MECP2:
dystonia-ov (Hereditary Dystonia Overview)
mecp2-dup (MECP2 Duplication Syndrome)
rett (MECP2 Disorders)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.