ID:MED14_HUMAN DESCRIPTION: RecName: Full=Mediator of RNA polymerase II transcription subunit 14; AltName: Full=Activator-recruited cofactor 150 kDa component; Short=ARC150; AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 2; Short=CRSP complex subunit 2; AltName: Full=Mediator complex subunit 14; AltName: Full=RGR1 homolog; Short=hRGR1; AltName: Full=Thyroid hormone receptor-associated protein complex 170 kDa component; Short=Trap170; AltName: Full=Transcriptional coactivator CRSP150; AltName: Full=Vitamin D3 receptor-interacting protein complex 150 kDa component; Short=DRIP150; FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. SUBUNIT: Interacts with GATA1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR, ESR1, SREBF1 and STAT2. INTERACTION: P00519:ABL1; NbExp=1; IntAct=EBI-394489, EBI-375543; P06241:FYN; NbExp=1; IntAct=EBI-394489, EBI-515315; P62993:GRB2; NbExp=1; IntAct=EBI-394489, EBI-401755; P16333:NCK1; NbExp=1; IntAct=EBI-394489, EBI-389883; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the Mediator complex subunit 14 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60244
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
