Human Gene MED19 (ENST00000431606.5_12) from GENCODE V47lift37
  Description: mediator complex subunit 19, transcript variant 1 (from RefSeq NM_001317078.4)
Gencode Transcript: ENST00000431606.5_12
Gencode Gene: ENSG00000156603.20_14
Transcript (Including UTRs)
   Position: hg19 chr11:57,471,182-57,479,687 Size: 8,506 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr11:57,471,510-57,479,651 Size: 8,142 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:57,471,182-57,479,687)mRNA (may differ from genome)Protein (244 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: J3KR33_HUMAN
DESCRIPTION: SubName: Full=Mediator of RNA polymerase II transcription subunit 19;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MED19
Diseases sorted by gene-association score: breast lipoma (8), congenital disorder of deglycosylation (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.03 RPKM in Testis
Total median expression: 371.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.4036-0.122 Picture PostScript Text
3' UTR -90.40328-0.276 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019403 - Mediator_Med19_met

Pfam Domains:
PF10278 - Mediator of RNA pol II transcription subunit 19

SCOP Domains:
101447 - Formin homology 2 domain (FH2 domain)

ModBase Predicted Comparative 3D Structure on J3KR33
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001104 RNA polymerase II transcription cofactor activity

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0016592 mediator complex
GO:0016604 nuclear body


-  Descriptions from all associated GenBank mRNAs
  U92995 - Homo sapiens clone DT2P1G7 mRNA, CAG repeat region.
BC037223 - Homo sapiens mediator complex subunit 19, mRNA (cDNA clone MGC:36746 IMAGE:5197938), complete cds.
AY148462 - Homo sapiens lung cancer metastasis-related protein (LCMR1) mRNA, complete cds.
JD359114 - Sequence 340138 from Patent EP1572962.
JD539744 - Sequence 520768 from Patent EP1572962.
JD524984 - Sequence 506008 from Patent EP1572962.
JD111479 - Sequence 92503 from Patent EP1572962.
JD160113 - Sequence 141137 from Patent EP1572962.
JD333791 - Sequence 314815 from Patent EP1572962.
JD199752 - Sequence 180776 from Patent EP1572962.
JD341325 - Sequence 322349 from Patent EP1572962.
JD204028 - Sequence 185052 from Patent EP1572962.
BC009723 - Homo sapiens mediator complex subunit 19, mRNA (cDNA clone IMAGE:3895048), partial cds.
AB463861 - Synthetic construct DNA, clone: pF1KB8202, Homo sapiens MED19 gene for mediator complex subunit 19, without stop codon, in Flexi system.
KJ895831 - Synthetic construct Homo sapiens clone ccsbBroadEn_05225 MED19 gene, encodes complete protein.
HE646678 - Homo sapiens mRNA for putative mediator subunit MED19AS protein (MED19AS gene).

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000431606.1, ENST00000431606.2, ENST00000431606.3, ENST00000431606.4, J3KR33, J3KR33_HUMAN, MED19 , NM_001317078, uc320aim.1, uc320aim.2
UCSC ID: ENST00000431606.5_12
RefSeq Accession: NM_001317078.4
Protein: J3KR33

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.