ID:MGMT_HUMAN DESCRIPTION: RecName: Full=Methylated-DNA--protein-cysteine methyltransferase; EC=2.1.1.63; AltName: Full=6-O-methylguanine-DNA methyltransferase; Short=MGMT; AltName: Full=O-6-methylguanine-DNA-alkyltransferase; FUNCTION: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. CATALYTIC ACTIVITY: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L- cysteine. COFACTOR: Binds 1 zinc ion. SUBCELLULAR LOCATION: Nucleus. MISCELLANEOUS: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. SIMILARITY: Belongs to the MGMT family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16455
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006266 DNA ligation GO:0006281 DNA repair GO:0006306 DNA methylation GO:0006307 DNA dealkylation involved in DNA repair GO:0006974 cellular response to DNA damage stimulus GO:0009636 response to toxic substance GO:0014070 response to organic cyclic compound GO:0032259 methylation GO:0034599 cellular response to oxidative stress GO:0042493 response to drug GO:0043066 negative regulation of apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045471 response to ethanol GO:0045739 positive regulation of DNA repair GO:0051593 response to folic acid GO:0060548 negative regulation of cell death GO:0060644 mammary gland epithelial cell differentiation GO:0071407 cellular response to organic cyclic compound GO:0071479 cellular response to ionizing radiation GO:2000781 positive regulation of double-strand break repair
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
