Human Gene MICA (ENST00000449934.7_4) from GENCODE V47lift37
  Description: MHC class I polypeptide-related sequence A, transcript variant 1*00801 (from RefSeq NM_001177519.3)
Gencode Transcript: ENST00000449934.7_4
Gencode Gene: ENSG00000204520.14_11
Transcript (Including UTRs)
   Position: hg19 chr6:31,371,372-31,383,092 Size: 11,721 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr6:31,371,410-31,380,208 Size: 8,799 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:31,371,372-31,383,092)mRNA (may differ from genome)Protein (332 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MICA
Diseases sorted by gene-association score: spondylitis (41), psoriatic arthritis (23), multiple myeloma (17), ocular toxoplasmosis (13), psoriasis (11), t-cell large granular lymphocyte leukemia (11), takayasu arteritis (9), arthropathy (9), large granular lymphocyte leukemia (8), histoplasmosis (7), chronic graft versus host disease (6), arthritis (6), indeterminate leprosy (5), adrenal cortical hypofunction (5), bare lymphocyte syndrome, type i (5), inflammatory bowel disease 3 (4), celiac disease (2), connective tissue disease (2), behcet syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 34.16 RPKM in Ovary
Total median expression: 800.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.8038-0.311 Picture PostScript Text
3' UTR -109.40333-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003597 - Ig_C1-set
IPR011161 - MHC_I-like_Ag-recog
IPR011162 - MHC_I/II-like_Ag-recog
IPR001039 - MHC_I_a_a1/a2

Pfam Domains:
PF00129 - Class I Histocompatibility antigen, domains alpha 1 and 2
PF07654 - Immunoglobulin C1-set domain

SCOP Domains:
48726 - Immunoglobulin
54452 - MHC antigen-recognition domain

ModBase Predicted Comparative 3D Structure on Q96QC4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK094237 - Homo sapiens cDNA FLJ36918 fis, clone BRACE2003954, highly similar to MHC class I chain-related gene A protein.
AK310028 - Homo sapiens cDNA, FLJ17070.
BC016929 - Homo sapiens MHC class I polypeptide-related sequence A, mRNA (cDNA clone MGC:21250 IMAGE:4446575), complete cds.
AK225393 - Homo sapiens mRNA for MHC class I chain-related gene A protein variant, clone: HRC02220.
L14848 - Human MHC class I-related protein mRNA, complete cds.
AK299135 - Homo sapiens cDNA FLJ60820 complete cds, highly similar to Homo sapiens MHC class I polypeptide-related sequence A (MICA), mRNA.
JD129805 - Sequence 110829 from Patent EP1572962.
CU677769 - Synthetic construct Homo sapiens gateway clone IMAGE:100019177 5' read MICA mRNA.
AB590509 - Synthetic construct DNA, clone: pFN21AE1864, Homo sapiens MICA gene for MHC class I polypeptide-related sequence A, without stop codon, in Flexi system.
HQ447839 - Synthetic construct Homo sapiens clone IMAGE:100071183; CCSB001079_01 MHC class I polypeptide-related sequence A (MICA) gene, encodes complete protein.
KJ901045 - Synthetic construct Homo sapiens clone ccsbBroadEn_10439 MICA gene, encodes complete protein.
KT183478 - Homo sapiens MHC class I related chain A isoform A (MICA) mRNA, MICA-*017 allele, complete cds, alternatively spliced.
KT183481 - Homo sapiens MHC class I related chain A isoform C (MICA) mRNA, MICA-*017 allele, complete cds, alternatively spliced.
KT183479 - Homo sapiens MHC class I related chain A isoform B1 (MICA) mRNA, MICA-*017 allele, complete cds, alternatively spliced.
AB506764 - Homo sapiens MICA mRNA for MHC class I chain-related protein A, complete cds.
AY204547 - Homo sapiens MHC class I related protein A (MICA) mRNA, MICA*001 variant allele, complete cds.
AY750850 - Homo sapiens MHC class I chain-related protein A (MICA) mRNA, MICA*00701 allele, complete cds.
KT183480 - Homo sapiens MHC class I related chain A isoform B2 (MICA) mRNA, MICA-*017 allele, complete cds, alternatively spliced.
KT183482 - Homo sapiens MHC class I related chain A isoform D (MICA) mRNA, MICA-*017 allele, complete cds, alternatively spliced.
AK311667 - Homo sapiens cDNA, FLJ18709.
FW573311 - JP 2010529847-A/32: Oligonucleotides for modulation of target RNA activity.
JD519705 - Sequence 500729 from Patent EP1572962.
JD392855 - Sequence 373879 from Patent EP1572962.
JD459965 - Sequence 440989 from Patent EP1572962.
JD185767 - Sequence 166791 from Patent EP1572962.
JD235118 - Sequence 216142 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000449934.1, ENST00000449934.2, ENST00000449934.3, ENST00000449934.4, ENST00000449934.5, ENST00000449934.6, hCG_2001511 , MICA , NM_001177519, Q96QC4, Q96QC4_HUMAN, uc320rkh.1, uc320rkh.2
UCSC ID: ENST00000449934.7_4
RefSeq Accession: NM_001177519.3
Protein: Q96QC4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.