ID:M1IP1_HUMAN DESCRIPTION: RecName: Full=Mid1-interacting protein 1; AltName: Full=Gastrulation-specific G12-like protein; AltName: Full=Mid1-interacting G12-like protein; AltName: Full=Protein STRAIT11499; AltName: Full=Spot 14-related protein; Short=S14R; Short=Spot 14-R; FUNCTION: Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity). SUBUNIT: Homodimer in the absence of THRSP. Heterodimer with THRSP. The homodimer interacts with ACACA and ACACB. Promotes polymerization of Acetyl-CoA carboxylase to form complexes that contain MID1IP1 and ACACA and/or ACACB. Interaction with THRSP interferes with ACACA binding (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with microtubules (By similarity). SIMILARITY: Belongs to the SPOT14 family. CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator. SEQUENCE CAUTION: Sequence=DAA01482.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07084 - Thyroid hormone-inducible hepatic protein Spot 14
ModBase Predicted Comparative 3D Structure on Q9NPA3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008022 protein C-terminus binding GO:0042802 identical protein binding
Biological Process: GO:0006629 lipid metabolic process GO:0006853 carnitine shuttle GO:0007026 negative regulation of microtubule depolymerization GO:0045723 positive regulation of fatty acid biosynthetic process GO:0046890 regulation of lipid biosynthetic process GO:0051258 protein polymerization GO:0051351 positive regulation of ligase activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
