Human Gene MIF4GD (ENST00000325102.13_8) from GENCODE V47lift37
  Description: MIF4G domain containing, transcript variant 11 (from RefSeq NM_001370592.1)
Gencode Transcript: ENST00000325102.13_8
Gencode Gene: ENSG00000125457.15_16
Transcript (Including UTRs)
   Position: hg19 chr17:73,262,309-73,267,312 Size: 5,004 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr17:73,262,821-73,266,276 Size: 3,456 Coding Exon Count: 5 

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Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:73,262,309-73,267,312)mRNA (may differ from genome)Protein (222 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MI4GD_HUMAN
DESCRIPTION: RecName: Full=MIF4G domain-containing protein; AltName: Full=SLBP-interacting protein 1; Short=hSLIP1;
FUNCTION: Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.
SUBUNIT: Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also interacts with EIF4G1 which is bound to their 5'-end.
INTERACTION: P56524:HDAC4; NbExp=4; IntAct=EBI-373498, EBI-308629;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
MISCELLANEOUS: Depletion of MIF4GD results in cell death and reduced histone mRNA translation.
SIMILARITY: Belongs to the MIF4GD family.
SIMILARITY: Contains 1 MIF4G domain.
SEQUENCE CAUTION: Sequence=AAG09724.1; Type=Frameshift; Positions=Several;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MIF4GD
Diseases sorted by gene-association score: retinitis pigmentosa 70 (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.38 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 314.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.20138-0.530 Picture PostScript Text
3' UTR -152.80512-0.298 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR016021 - MIF4-like_typ_1/2/3
IPR003890 - MIF4G-like_typ-3

Pfam Domains:
PF02854 - MIF4G domain

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on A9UHW6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding

Biological Process:
GO:0006417 regulation of translation

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  LF209419 - JP 2014500723-A/16922: Polycomb-Associated Non-Coding RNAs.
AF225422 - Homo sapiens AD023 mRNA, complete cds.
BC033759 - Homo sapiens MIF4G domain containing, mRNA (cDNA clone MGC:45027 IMAGE:5215495), complete cds.
EU287989 - Homo sapiens SLBP-interacting protein 1 (SLIP1) mRNA, complete cds.
JD303011 - Sequence 284035 from Patent EP1572962.
JD546405 - Sequence 527429 from Patent EP1572962.
JD095542 - Sequence 76566 from Patent EP1572962.
JD243537 - Sequence 224561 from Patent EP1572962.
JD100726 - Sequence 81750 from Patent EP1572962.
JD297626 - Sequence 278650 from Patent EP1572962.
JD433171 - Sequence 414195 from Patent EP1572962.
LF328402 - JP 2014500723-A/135905: Polycomb-Associated Non-Coding RNAs.
JD502761 - Sequence 483785 from Patent EP1572962.
JD367992 - Sequence 349016 from Patent EP1572962.
AK300711 - Homo sapiens cDNA FLJ51624 complete cds, moderately similar to Rattus norvegicus MIF4G domain containing (Mif4gd), mRNA.
LF328403 - JP 2014500723-A/135906: Polycomb-Associated Non-Coding RNAs.
DQ600465 - Homo sapiens piRNA piR-38531, complete sequence.
DQ890815 - Synthetic construct clone IMAGE:100003445; FLH166172.01X; RZPDo839D0886D MIF4G domain containing (MIF4GD) gene, encodes complete protein.
CU689726 - Synthetic construct Homo sapiens gateway clone IMAGE:100016903 5' read MIF4GD mRNA.
KJ894424 - Synthetic construct Homo sapiens clone ccsbBroadEn_03818 MIF4GD gene, encodes complete protein.
DQ893971 - Synthetic construct Homo sapiens clone IMAGE:100008431; FLH166168.01L; RZPDo839D0885D MIF4G domain containing (MIF4GD) gene, encodes complete protein.
KU178731 - Homo sapiens MIF4G domain containing isoform 1 (MIF4GD) mRNA, partial cds.
KU178732 - Homo sapiens MIF4G domain containing isoform 2 (MIF4GD) mRNA, partial cds, alternatively spliced.
KU178733 - Homo sapiens MIF4G domain containing isoform 3 (MIF4GD) mRNA, partial cds, alternatively spliced.
KU178734 - Homo sapiens MIF4G domain containing isoform 4 (MIF4GD) mRNA, partial cds, alternatively spliced.
LF328405 - JP 2014500723-A/135908: Polycomb-Associated Non-Coding RNAs.
LF328408 - JP 2014500723-A/135911: Polycomb-Associated Non-Coding RNAs.
LF328412 - JP 2014500723-A/135915: Polycomb-Associated Non-Coding RNAs.
JD239953 - Sequence 220977 from Patent EP1572962.
JD461636 - Sequence 442660 from Patent EP1572962.
MA563979 - JP 2018138019-A/135905: Polycomb-Associated Non-Coding RNAs.
MA563980 - JP 2018138019-A/135906: Polycomb-Associated Non-Coding RNAs.
MA563982 - JP 2018138019-A/135908: Polycomb-Associated Non-Coding RNAs.
MA563985 - JP 2018138019-A/135911: Polycomb-Associated Non-Coding RNAs.
MA563989 - JP 2018138019-A/135915: Polycomb-Associated Non-Coding RNAs.
MA444996 - JP 2018138019-A/16922: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A9UHW6, B4DUM7, ENST00000325102.1, ENST00000325102.10, ENST00000325102.11, ENST00000325102.12, ENST00000325102.2, ENST00000325102.3, ENST00000325102.4, ENST00000325102.5, ENST00000325102.6, ENST00000325102.7, ENST00000325102.8, ENST00000325102.9, MI4GD_HUMAN, NM_001370592, Q8N4Q5, Q9HBL5, SLIP1, uc317rul.1, uc317rul.2
UCSC ID: ENST00000325102.13_8
RefSeq Accession: NM_001370592.1
Protein: A9UHW6 (aka MI4GD_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.