Human Gene MIOS (ENST00000340080.9_4) from GENCODE V47lift37
  Description: meiosis regulator for oocyte development, transcript variant 1 (from RefSeq NM_019005.4)
Gencode Transcript: ENST00000340080.9_4
Gencode Gene: ENSG00000164654.16_8
Transcript (Including UTRs)
   Position: hg19 chr7:7,606,515-7,648,563 Size: 42,049 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr7:7,612,107-7,646,723 Size: 34,617 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:7,606,515-7,648,563)mRNA (may differ from genome)Protein (875 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MIO_HUMAN
DESCRIPTION: RecName: Full=WD repeat-containing protein mio;
SIMILARITY: Belongs to the WD repeat mio family.
SIMILARITY: Contains 6 WD repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.50 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 383.54 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -168.70409-0.412 Picture PostScript Text
3' UTR -406.101840-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat

Pfam Domains:
PF17034 - Zinc-ribbon like family

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q9NXC5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0032008 positive regulation of TOR signaling
GO:0034198 cellular response to amino acid starvation
GO:0034629 cellular protein complex localization

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0030054 cell junction
GO:0061700 GATOR2 complex


-  Descriptions from all associated GenBank mRNAs
  BC068512 - Homo sapiens cDNA clone IMAGE:5294912, containing frame-shift errors.
AK294561 - Homo sapiens cDNA FLJ61235 complete cds, weakly similar to WD repeat protein YBL104C.
AK000330 - Homo sapiens cDNA FLJ20323 fis, clone HEP09648.
BC140833 - Homo sapiens missing oocyte, meiosis regulator, homolog (Drosophila), mRNA (cDNA clone MGC:176510 IMAGE:9021701), complete cds.
BC140834 - Homo sapiens missing oocyte, meiosis regulator, homolog (Drosophila), mRNA (cDNA clone MGC:176511 IMAGE:9021702), complete cds.
JD052296 - Sequence 33320 from Patent EP1572962.
KJ898987 - Synthetic construct Homo sapiens clone ccsbBroadEn_08381 MIOS gene, encodes complete protein.
BC005883 - Homo sapiens missing oocyte, meiosis regulator, homolog (Drosophila), mRNA (cDNA clone IMAGE:3535684), partial cds.
AL136892 - Homo sapiens mRNA; cDNA DKFZp434J087 (from clone DKFZp434J087).
JD369291 - Sequence 350315 from Patent EP1572962.
JD168268 - Sequence 149292 from Patent EP1572962.
JD284147 - Sequence 265171 from Patent EP1572962.
JD109930 - Sequence 90954 from Patent EP1572962.
JD520962 - Sequence 501986 from Patent EP1572962.
JD148051 - Sequence 129075 from Patent EP1572962.
JD276721 - Sequence 257745 from Patent EP1572962.
AK096829 - Homo sapiens cDNA FLJ39510 fis, clone PROST2018487.
JD121217 - Sequence 102241 from Patent EP1572962.
JD527225 - Sequence 508249 from Patent EP1572962.
JD330351 - Sequence 311375 from Patent EP1572962.
JD282618 - Sequence 263642 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RTV6, ENST00000340080.1, ENST00000340080.2, ENST00000340080.3, ENST00000340080.4, ENST00000340080.5, ENST00000340080.6, ENST00000340080.7, ENST00000340080.8, MIOS , MIOS_HUMAN, NM_019005, O75216, Q7L551, Q9H092, Q9NXC5, uc317voe.1, uc317voe.2
UCSC ID: ENST00000340080.9_4
RefSeq Accession: NM_019005.4
Protein: Q9NXC5 (aka MIO_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.