Human Gene MISP (ENST00000215582.8_4) from GENCODE V47lift37

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Description: mitotic spindle positioning, transcript variant 2 (from RefSeq NR_135168.2)
Gencode Transcript: ENST00000215582.8_4
Gencode Gene: ENSG00000099812.9_14
Transcript (Including UTRs)
Position: hg19 chr19:751,112-764,318 Size: 13,207 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr19:756,947-763,590 Size: 6,644 Coding Exon Count: 4

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	RNA-Seq Expression
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:751,112-764,318)			mRNA (may differ from genome)		Protein (679 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	MGI
OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D019327 Copper Sulfate D012643 Selenium D013749 Tetrachlorodibenzodioxin C006632 arsenic trioxide

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 113.15 RPKM in Small Intestine - Terminal Ileum Total median expression: 232.80 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-42.00	117	-0.359	Picture	PostScript	Text
3' UTR	-277.30	728	-0.381	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

Pfam Domains:
PF15304 - A-kinase anchor protein 2 C-terminus

ModBase Predicted Comparative 3D Structure on Q8IVT2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003779 actin binding Biological Process: GO:0007049 cell cycle GO:0051301 cell division Cellular Component: GO:0005737 cytoplasm GO:0005856 cytoskeleton GO:0005886 plasma membrane GO:0005925 focal adhesion GO:0005938 cell cortex GO:0030054 cell junction GO:0043231 intracellular membrane-bounded organelle

Descriptions from all associated GenBank mRNAs


	BC052236 - Homo sapiens chromosome 19 open reading frame 21, mRNA (cDNA clone MGC:59967 IMAGE:5431360), complete cds. BX648389 - Homo sapiens mRNA; cDNA DKFZp686H18209 (from clone DKFZp686H18209). BC042125 - Homo sapiens chromosome 19 open reading frame 21, mRNA (cDNA clone MGC:9237 IMAGE:3848272), complete cds. JD369024 - Sequence 350048 from Patent EP1572962. JD177764 - Sequence 158788 from Patent EP1572962. KJ895420 - Synthetic construct Homo sapiens clone ccsbBroadEn_04814 C19orf21 gene, encodes complete protein. BX648815 - Homo sapiens mRNA; cDNA DKFZp686J17231 (from clone DKFZp686J17231). JD392031 - Sequence 373055 from Patent EP1572962. JD376438 - Sequence 357462 from Patent EP1572962. JD206817 - Sequence 187841 from Patent EP1572962. JD447777 - Sequence 428801 from Patent EP1572962. JD085387 - Sequence 66411 from Patent EP1572962. JD470553 - Sequence 451577 from Patent EP1572962. JD323566 - Sequence 304590 from Patent EP1572962. JD361594 - Sequence 342618 from Patent EP1572962. JD208529 - Sequence 189553 from Patent EP1572962. JD349260 - Sequence 330284 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: C19orf21 , ENST00000215582.1, ENST00000215582.2, ENST00000215582.3, ENST00000215582.4, ENST00000215582.5, ENST00000215582.6, ENST00000215582.7, MISP , MISP_HUMAN, NR_135168, Q8IVT2, uc317cmg.1, uc317cmg.2 UCSC ID: ENST00000215582.8_4 RefSeq Accession: NM_173481.4 Protein: Q8IVT2 (aka CS021_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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