Human Gene MRTFA (ENST00000402630.5_7) from GENCODE V47lift37
  Description: Binds PPP1CA and actin. (from UniProt B0QY84)
Gencode Transcript: ENST00000402630.5_7
Gencode Gene: ENSG00000196588.21_21
Transcript (Including UTRs)
   Position: hg19 chr22:40,825,355-40,859,422 Size: 34,068 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr22:40,825,425-40,859,231 Size: 33,807 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:40,825,355-40,859,422)mRNA (may differ from genome)Protein (161 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblExonPrimerGeneCardsMGIPubMedUniProtKB
Wikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.99 RPKM in Testis
Total median expression: 414.85 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.00191-0.230 Picture PostScript Text
3' UTR -15.7070-0.224 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004018 - RPEL_repeat

Pfam Domains:
PF02755 - RPEL repeat

ModBase Predicted Comparative 3D Structure on B0QY84
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003713 transcription coactivator activity
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0004864 protein phosphatase inhibitor activity

Biological Process:
GO:0010735 positive regulation of transcription via serum response element binding
GO:0032515 negative regulation of phosphoprotein phosphatase activity

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC115039 - Homo sapiens megakaryoblastic leukemia (translocation) 1, mRNA (cDNA clone MGC:131756 IMAGE:5551767), complete cds.
HG764171 - Homo sapiens mRNA for MKL1 variant 1 MKL1_S.
AF368061 - Homo sapiens megakaryoblastic leukemia-1 protein (MKL1) mRNA, complete cds.
AB037859 - Homo sapiens KIAA1438 mRNA for KIAA1438 protein.
BC064620 - Homo sapiens megakaryoblastic leukemia (translocation) 1, mRNA (cDNA clone IMAGE:5591634), partial cds.
AJ297258 - Homo sapiens mRNA for megacaryocytic acute leukemia protein (MAL gene), isoform I.
BC139730 - Homo sapiens megakaryoblastic leukemia (translocation) 1, mRNA (cDNA clone IMAGE:40028619).
AF364036 - Homo sapiens megakaryoblastic leukemia-1 protein/RNA-binding motif protein 15s fusion protein (MKL1/RBM15 fusion) mRNA, complete cds.
AF364037 - Homo sapiens megakaryoblastic leukemia-1 protein/RNA-binding motif protein 15s + ae fusion protein (MKL1/RBM15 fusion) mRNA, complete cds.
AF448806 - Homo sapiens MKL1 mRNA, 5' untranslated region, partial sequence; alternatively spliced.
AJ303090 - Homo sapiens mRNA for OTT-MAL protein resulting from common (1;22) translocation breakpoint.
AJ303089 - Homo sapiens mRNA for OTT-MAL protein resulting from variant (1;22) translocation breakpoint.
AJ297257 - Homo sapiens mRNA for megacaryocytic acute leukemia (MAL gene).
CR456522 - Homo sapiens MKL1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.MKL1).
BC141653 - Synthetic construct Homo sapiens clone IMAGE:100000379, MGC:164688 megakaryoblastic leukemia (translocation) 1 (MKL1) mRNA, encodes complete protein.
CU013122 - Homo sapiens MKL1, mRNA (cDNA clone IMAGE:100000379), complete cds, with stop codon, in Gateway system.
AB384209 - Synthetic construct DNA, clone: pF1KSDA1438, Homo sapiens MKL1 gene for MKL/myocardin-like protein 1, complete cds, without stop codon, in Flexi system.
BC141655 - Synthetic construct Homo sapiens clone IMAGE:100000283, MGC:164695 megakaryoblastic leukemia (translocation) 1 (MKL1) mRNA, encodes complete protein.
CU013410 - Homo sapiens MKL1, mRNA (cDNA clone IMAGE:100000283), complete cds, without stop codon, in Gateway system.
AF364035 - Homo sapiens RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein (RBM15/MKL1 fusion) mRNA, partial cds.
JD435957 - Sequence 416981 from Patent EP1572962.
JD461634 - Sequence 442658 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AJ297257, B0QY84, B0QY84_HUMAN, ENST00000402630.1, ENST00000402630.2, ENST00000402630.3, ENST00000402630.4, hCG_41119 , MKL1 , MRTFA , uc319bxc.1, uc319bxc.2
UCSC ID: ENST00000402630.5_7
RefSeq Accession: NM_001282660.2
Protein: B0QY84

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.