Human Gene MKNK1 (ENST00000371945.10_11) from GENCODE V47lift37
  Description: MAPK interacting serine/threonine kinase 1, transcript variant 8 (from RefSeq NM_001377373.1)
Gencode Transcript: ENST00000371945.10_11
Gencode Gene: ENSG00000079277.22_21
Transcript (Including UTRs)
   Position: hg19 chr1:47,023,079-47,069,940 Size: 46,862 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr1:47,024,247-47,048,999 Size: 24,753 Coding Exon Count: 11 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:47,023,079-47,069,940)mRNA (may differ from genome)Protein (412 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 47.13 RPKM in Whole Blood
Total median expression: 669.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.10254-0.296 Picture PostScript Text
3' UTR -373.601168-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  BC002755 - Homo sapiens MAP kinase interacting serine/threonine kinase 1, mRNA (cDNA clone MGC:3690 IMAGE:3629765), complete cds.
AB000409 - Homo sapiens mRNA for MNK1, complete cds.
AK096423 - Homo sapiens cDNA FLJ39104 fis, clone NTONG2004614, highly similar to Homo sapiens MAP kinase interacting serine/threonine kinase 1 (MKNK1), transcript variant 2, mRNA.
AK298839 - Homo sapiens cDNA FLJ55013 complete cds, highly similar to Homo sapiens MAP kinase interacting serine/threonine kinase 1 (MKNK1), transcript variant 2, mRNA.
AB451300 - Homo sapiens MKNK1 mRNA for MAP kinase interacting serine/threonine kinase 1, complete cds, clone: FLJ08156AAAN.
DQ892992 - Synthetic construct clone IMAGE:100005622; FLH191469.01X; RZPDo839D0777D MAP kinase interacting serine/threonine kinase 1 (MKNK1) gene, encodes complete protein.
DQ896240 - Synthetic construct Homo sapiens clone IMAGE:100010700; FLH191465.01L; RZPDo839D0767D MAP kinase interacting serine/threonine kinase 1 (MKNK1) gene, encodes complete protein.
EU831624 - Synthetic construct Homo sapiens clone HAIB:100066653; DKFZo007D0919 MAP kinase interacting serine/threonine kinase 1 protein (MKNK1) gene, encodes complete protein.
AB451432 - Homo sapiens MKNK1 mRNA for MAP kinase interacting serine/threonine kinase 1, partial cds, clone: FLJ08156AAAF.
AB587537 - Synthetic construct DNA, clone: pF1KE0796, Homo sapiens MKNK1 gene for MAP kinase interacting serine/threonine kinase 1, without stop codon, in Flexi system.
EU831709 - Synthetic construct Homo sapiens clone HAIB:100066738; DKFZo003D0920 MAP kinase interacting serine/threonine kinase 1 protein (MKNK1) gene, encodes complete protein.
AY355461 - Homo sapiens MNK1-like kinase 1b (MNK1B) mRNA, complete cds.
AK290456 - Homo sapiens cDNA FLJ77058 complete cds, highly similar to Homo sapiens MAP kinase interacting serine/threonine kinase 1 (MKNK1), transcript variant 2, mRNA.
AK310566 - Homo sapiens cDNA, FLJ17608.
BX648559 - Homo sapiens mRNA; cDNA DKFZp779E1340 (from clone DKFZp779E1340).
AK304005 - Homo sapiens cDNA FLJ59008 complete cds, highly similar to MAP kinase-interactingserine/threonine-protein kinase 1 (EC 2.7.11.1).
BX538193 - Homo sapiens mRNA; cDNA DKFZp686E14208 (from clone DKFZp686E14208); complete cds.
JD050791 - Sequence 31815 from Patent EP1572962.
JD454018 - Sequence 435042 from Patent EP1572962.
JD428682 - Sequence 409706 from Patent EP1572962.
JD130135 - Sequence 111159 from Patent EP1572962.
JD527014 - Sequence 508038 from Patent EP1572962.
JD283972 - Sequence 264996 from Patent EP1572962.
JD561774 - Sequence 542798 from Patent EP1572962.
JD551643 - Sequence 532667 from Patent EP1572962.
JD377856 - Sequence 358880 from Patent EP1572962.
JD310171 - Sequence 291195 from Patent EP1572962.
JD381540 - Sequence 362564 from Patent EP1572962.
JD305588 - Sequence 286612 from Patent EP1572962.
JD156123 - Sequence 137147 from Patent EP1572962.
JD156383 - Sequence 137407 from Patent EP1572962.
JD480315 - Sequence 461339 from Patent EP1572962.
JD413199 - Sequence 394223 from Patent EP1572962.
JD129303 - Sequence 110327 from Patent EP1572962.
JD055042 - Sequence 36066 from Patent EP1572962.
JD218012 - Sequence 199036 from Patent EP1572962.
JD376895 - Sequence 357919 from Patent EP1572962.
JD288735 - Sequence 269759 from Patent EP1572962.
JD122477 - Sequence 103501 from Patent EP1572962.
JD489500 - Sequence 470524 from Patent EP1572962.
JD297244 - Sequence 278268 from Patent EP1572962.
JD133115 - Sequence 114139 from Patent EP1572962.
JD370491 - Sequence 351515 from Patent EP1572962.
JD421039 - Sequence 402063 from Patent EP1572962.
JD226555 - Sequence 207579 from Patent EP1572962.
JD067863 - Sequence 48887 from Patent EP1572962.
AK308924 - Homo sapiens cDNA, FLJ98965.
AK096986 - Homo sapiens cDNA FLJ39667 fis, clone SMINT2007647.
JD245179 - Sequence 226203 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_mapkPathway - MAPKinase Signaling Pathway
h_p38mapkPathway - p38 MAPK Signaling Pathway
h_mTORPathway - mTOR Signaling Pathway
h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_erkPathway - Erk1/Erk2 Mapk Signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: A0A499FJN1, A0A499FJN1_HUMAN, ENST00000371945.1, ENST00000371945.2, ENST00000371945.3, ENST00000371945.4, ENST00000371945.5, ENST00000371945.6, ENST00000371945.7, ENST00000371945.8, ENST00000371945.9, MKNK1 , NM_001377373, uc318jnk.1, uc318jnk.2
UCSC ID: ENST00000371945.10_11
RefSeq Accession: NM_001135553.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.