Human Gene MLF1 (ENST00000466246.7_9) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: myeloid leukemia factor 1, transcript variant 9 (from RefSeq NM_001369783.1)
Gencode Transcript: ENST00000466246.7_9
Gencode Gene: ENSG00000178053.21_18
Transcript (Including UTRs)
Position: hg19 chr3:158,288,983-158,324,245 Size: 35,263 Total Exon Count: 8 Strand: +
Coding Region
Position: hg19 chr3:158,289,090-158,322,991 Size: 33,902 Coding Exon Count: 8

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:158,288,983-158,324,245)			mRNA (may differ from genome)		Protein (283 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: MLF1 Diseases sorted by gene-association score: myeloid leukemia (45), leukemia, acute myeloid* (32), myelodysplastic syndrome (17), leukemia (15) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D014635 Valproic Acid D000393 Air Pollutants D001564 Benzo(a)pyrene D002117 Calcitriol D002737 Chloroprene D019327 Copper Sulfate D003375 Coumestrol D004958 Estradiol D005472 Fluorouracil D019833 Genistein more ... click here to view the complete list

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 138.14 RPKM in Testis Total median expression: 318.29 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-36.00	107	-0.336	Picture	PostScript	Text
3' UTR	-228.80	1254	-0.182	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	HM005672 - Homo sapiens clone HTL-T-49e testis tissue sperm-binding protein Li 49e mRNA, complete cds. AK315402 - Homo sapiens cDNA, FLJ96451, highly similar to Homo sapiens myeloid leukemia factor 1 (MLF1), mRNA. AK056948 - Homo sapiens cDNA FLJ32386 fis, clone SKMUS1000118, highly similar to Homo sapiens t(3;5)(q25.1;p34) fusion gene NPM-MLF1 mRNA. BC095437 - Homo sapiens cDNA clone IMAGE:30720866, containing frame-shift errors. BX647666 - Homo sapiens mRNA; cDNA DKFZp313B1621 (from clone DKFZp313B1621). AY848701 - Homo sapiens myeloid leukemia factor 1 variant 2 (MLF1) mRNA, complete cds, alternatively spliced. BC007045 - Homo sapiens myeloid leukemia factor 1, mRNA (cDNA clone MGC:12449 IMAGE:3996145), complete cds. AY848700 - Homo sapiens myeloid leukemia factor 1 variant 1 (MLF1) mRNA, complete cds, alternatively spliced. AY848702 - Homo sapiens myeloid leukemia factor 1 variant 3 (MLF1) mRNA, complete cds, alternatively spliced. L49054 - Homo sapiens t(3;5)(q25.1;p34) fusion gene NPM-MLF1 mRNA, complete cds. JD396399 - Sequence 377423 from Patent EP1572962. AK297488 - Homo sapiens cDNA FLJ52995 complete cds, highly similar to Myeloid leukemia factor 1. AK096889 - Homo sapiens cDNA FLJ39570 fis, clone SKMUS2001850, highly similar to Homo sapiens t(3;5)(q25.1;p34) fusion gene NPM-MLF1 mRNA. JD128586 - Sequence 109610 from Patent EP1572962. JD334592 - Sequence 315616 from Patent EP1572962. KU178186 - Homo sapiens myeloid leukemia factor 1 isoform 1 (MLF1) mRNA, partial cds. KU178187 - Homo sapiens myeloid leukemia factor 1 isoform 2 (MLF1) mRNA, partial cds, alternatively spliced. KU178188 - Homo sapiens myeloid leukemia factor 1 isoform 5 (MLF1) mRNA, complete cds, alternatively spliced. KJ891624 - Synthetic construct Homo sapiens clone ccsbBroadEn_01018 MLF1 gene, encodes complete protein. HZ473921 - WO 2016002844-A/35: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL. HZ473919 - WO 2016002844-A/33: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL. HZ473922 - WO 2016002844-A/36: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL. HZ473920 - WO 2016002844-A/34: ANTI-INVASIVE/ANTI-METASTATIC DRUG FOR PANCREATIC CANCER CELL. BX641078 - Homo sapiens mRNA; cDNA DKFZp686A04129 (from clone DKFZp686A04129).

Other Names for This Gene


	Alternate Gene Symbols: A0A0S2Z4A4, A0A0S2Z4A4_HUMAN, C9J3M3, ENST00000466246.1, ENST00000466246.2, ENST00000466246.3, ENST00000466246.4, ENST00000466246.5, ENST00000466246.6, hCG_16019 , MLF1 , NM_001369783, uc321imh.1, uc321imh.2 UCSC ID: ENST00000466246.7_9 RefSeq Accession: NM_001369783.1

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.