Human Gene MLLT11 (ENST00000368921.5_4) from GENCODE V47lift37
  Description: MLLT11 transcription factor 7 cofactor (from RefSeq NM_006818.4)
Gencode Transcript: ENST00000368921.5_4
Gencode Gene: ENSG00000213190.4_7
Transcript (Including UTRs)
   Position: hg19 chr1:151,032,873-151,042,020 Size: 9,148 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr1:151,039,701-151,039,973 Size: 273 Coding Exon Count: 1 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:151,032,873-151,042,020)mRNA (may differ from genome)Protein (90 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MLLT11
Diseases sorted by gene-association score: myeloid/lymphoid or mixed lineage leukemia (7), retinitis pigmentosa 42 (2), leukemia, acute myeloid (0)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.40163-0.266 Picture PostScript Text
3' UTR -527.902047-0.258 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026778 - MLLT11_fam

Pfam Domains:
PF15017 - Putative WW-binding domain and destruction box

ModBase Predicted Comparative 3D Structure on Q6FGF7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0097190 apoptotic signaling pathway

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC022448 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11, mRNA (cDNA clone MGC:25990 IMAGE:4815214), complete cds.
AK056089 - Homo sapiens cDNA FLJ31527 fis, clone NT2RI2000344, highly similar to Protein AF1q.
U16954 - Human (AF1q) mRNA, complete cds.
BC021703 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11, mRNA (cDNA clone MGC:24555 IMAGE:4108071), complete cds.
BC032996 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11, mRNA (cDNA clone IMAGE:5262434).
JD077474 - Sequence 58498 from Patent EP1572962.
BC009624 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11, mRNA (cDNA clone MGC:17309 IMAGE:3878959), complete cds.
AK057755 - Homo sapiens cDNA FLJ25026 fis, clone CBL02304.
BC007079 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11, mRNA (cDNA clone IMAGE:4049657).
BC008445 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11, mRNA (cDNA clone MGC:14664 IMAGE:4103485), complete cds.
BC019253 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11, mRNA (cDNA clone MGC:1273 IMAGE:3502660), complete cds.
JD372531 - Sequence 353555 from Patent EP1572962.
BC006471 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11, mRNA (cDNA clone MGC:4013 IMAGE:2823316), complete cds.
CR542150 - Homo sapiens full open reading frame cDNA clone RZPDo834F0923D for gene AF1Q, ALL1-fused gene from chromosome 1q; complete cds, without stopcodon.
DQ894604 - Synthetic construct Homo sapiens clone IMAGE:100009064; FLH176859.01L; RZPDo839A04123D myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 (MLLT11) gene, encodes complete protein.
BT006799 - Homo sapiens ALL1-fused gene from chromosome 1q mRNA, complete cds.
DQ891429 - Synthetic construct clone IMAGE:100004059; FLH176862.01X; RZPDo839A04124D myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 (MLLT11) gene, encodes complete protein.
KJ893182 - Synthetic construct Homo sapiens clone ccsbBroadEn_02576 MLLT11 gene, encodes complete protein.
CR456879 - Homo sapiens full open reading frame cDNA clone RZPDo834A017D for gene AF1Q, ALL1-fused gene from chromosome 1q; complete cds, incl. stopcodon.
JD043420 - Sequence 24444 from Patent EP1572962.
JD330414 - Sequence 311438 from Patent EP1572962.
JD326704 - Sequence 307728 from Patent EP1572962.
JD164751 - Sequence 145775 from Patent EP1572962.
JD252723 - Sequence 233747 from Patent EP1572962.
JD126875 - Sequence 107899 from Patent EP1572962.
JD061313 - Sequence 42337 from Patent EP1572962.
JD244099 - Sequence 225123 from Patent EP1572962.
JD193625 - Sequence 174649 from Patent EP1572962.
JD099691 - Sequence 80715 from Patent EP1572962.
JD374724 - Sequence 355748 from Patent EP1572962.
JD524280 - Sequence 505304 from Patent EP1572962.
JD181225 - Sequence 162249 from Patent EP1572962.
JD547311 - Sequence 528335 from Patent EP1572962.
JD165144 - Sequence 146168 from Patent EP1572962.
JD356425 - Sequence 337449 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AF1Q , ENST00000368921.1, ENST00000368921.2, ENST00000368921.3, ENST00000368921.4, hCG_1778767 , MLLT11 , NM_006818, Q6FGF7, Q6FGF7_HUMAN, uc318heo.1, uc318heo.2
UCSC ID: ENST00000368921.5_4
RefSeq Accession: NM_006818.4
Protein: Q6FGF7

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.